ESPE Abstracts

Objectives: To compare the levels of estradiol (E2) in girls measured by liquid chromatography tandem-mass spectrometry (LC-MS/MS) and chemiluminescence immunoassay (CLIA), and to evaluate the correlations between E2 levels measured by the two methods and bone age, uterine length, and uterine volume. To explore the difference, consistency, and accuracy of LC-MS/MS and CLIA in determining E2 in girls with idiopathic central precocious puberty (ICPP), premature ...

Objective: In order to investigate the effect of precocity and gonadotropin-releasing hormone analogists (GnRHa) GnRHa treatment on glucose metabolism in female rats, the possible mechanism was studied through the changes of leptin, estrogen, growth hormone, insulin-like growth factor 1 and insulin receptor signal crosslinking pathway.Methods: Forty-eight 2-day-old female Sprague-Dawley (SD) suckers were randomly divided...

Research Objectives: Studies have shown that Akkermansiella mucinophila has a positive effect in various metabolic diseases, and can also prevent the onset of spontaneous type 1 diabetic NOD mice. However, its effect on type 1 diabetic mice is not clear. The purpose of this study is to analyze the effect of Akkermansiella mucinophila intervention on type 1 diabetic mice.Research Methods: Thirty male C57BL / 6 mice aged 3...

Objective: Type E brachydactyly (BDE) is characterized by shortening of the metacarpal/metatarsal bones, with the phalanges also potentially affected. This study analyzes the clinical features and genotype-phenotype correlations of BDE in children.Methods: This study selected 135 patients with BDE who visited the Children's Hospital affiliated with Soochow University from June 2021 to December 2023 and completed a b...

Objective: Hypophosphatasia (HPP) is a monogenic metabolic bone disease characterized by skeletal and dental mineralization disorders and paradoxically low serum alkaline phosphatase (ALP) activity. The pathogenic gene for HPP is ALPL, which encodes tissue-nonspecific alkaline phosphatase (TNSALP). The purpose of this study is to determine the prevalence of HPP among the population in Suzhou and explore the genotypic spectrum of ALPL gene in ...

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist which has been confirmed that it offered kidney-protective effects in patients with type 2 diabetes and chronic kidney disease. However, the exact mechanism by which Semaglutide exerts its reno-protection remains largely unknown.Purpose: This study aim ed to investigate whether Semaglutide has beneficial effects in diabetic nephropathy mice via the gut...

Objective: This study analyzed ten short stature patients with growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis gene variants, and aim ed to explore both clinical and genetic characteristics, as well as the recombinant human growth hormone (rhGH) treatment response through a review of the literature.Methods: The clinical characteristics and response to rhGH treatment in 10 patients with GH1, GHR</...

Objective: The models of diagnosis of central precocious puberty (CPP) in girls were constructed based on machine learning algorithm to assist the management of CPP diagnosis in girls.Methods: Girls who visited the department of endocrinology, genetics and metabolism of the Fuzhou Children's Hospital of Fujian Medical University from January 2014 to June 2023 and were consistent with the diagnosis of precocious pube...

Objectives: By comparing the changes of bone turnover markers (BTMs) and bone mineral density (BMD) in girls with ICPP and RPP at different treatment time, To evaluate the effect of GnRHa treatment on bone metabolism in children.Methods: The girls with ICPP and RPP aged 7-10 years old: who undergoing treatment with GnRHa were selected, participants were categorized into the pre-treatment group (n = 61), half-yea...

Objective: To describe the clinical characteristics of a child with 21-hydroxylase deficiency (21OHD) combined with familial hypercholesterolemia (FH), who also developed Kawasaki disease (KD), and to follow up over a long period.Methods: Clinical data of a boy with 21OHD combined with FH were collected. Treatments with hydrocortisone, fludrocortisone, atorvastatin, and ezetimibe were administered, with monitoring of the...