hrp0098p1-51 | GH and IGFs 1 | ESPE2024

The Metabolic Impacts of GH Therapy in SGA Children and Its Effects on Various Metabolic Parameters and Health Outcomes

Alyafei Fawzia , Soliman Ashraf , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Elsiddig Sohair

Introduction: Children born small for gestational age (SGA) are susceptible to abnormal glucose metabolism and insulin resistance, which may be exacerbated by (GH) therapy.Methods: A comprehensive analysis of existing literature was conducted to assess the outcomes and implications of GH treatment in this specific pediatric population.Results: 10 studies were reviewed, (1458 SGA ch...

hrp0098p1-52 | GH and IGFs 1 | ESPE2024

Changes in Length and Weight Standard Deviation Scores in Children with Growth Hormone Deficiency Across Various Studies

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Ahmed Shayma , Abdulkayoum Anas , Hamed Noor , Sabt Amal

Background: The infantile growth parameters of children diagnosed later in life with GH-deficiency is still very controversial.Methods: We synthesized data from eight key studies, spanning from 1984 to 2003, alongside our current patient data. The LSDS and WtSDS at birth, 2 months, and 24 months are compared, noting the presence or absence of significant growth retardation or deviation from expected growth standards....

hrp0098p1-53 | GH and IGFs 1 | ESPE2024

Correlation of Growth Hormone Secretion and Infantile Growth Patterns in Children Diagnosed with Growth Hormone Deficiency (GHD)

Soliman Ashraf , Alyafei Fawzia , Abdulkayoum Anas , Elsiddig Sohair , Ahmed Shayma , Hamed Noor , Alaaraj Nada

Introduction: Growth Hormone Deficiency (GHD) is a critical condition that impairs the normal growth patterns in children, leading to various health challenges. Previous studies, including that by Leger et al. (1996), have characterized the secretion curve of growth hormone (GH) in early childhood. Our study aims to link the timed infantile growth data, specifically Length and Weight Standard Deviation Scores (LSDS and WTSDS), of children with diagnos...

hrp0098p1-54 | GH and IGFs 1 | ESPE2024

Should MRI Be Performed on the Pituitary Gland in Short Stature Children with Peak Growth Hormone Levels Between 5 and 7 Micrograms/Liter Following Provocation Tests?"

Hamed Noor , Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Ahmed Shayma , Qusad Mohamed , Elsiddig Sohair

Background: The precise growth hormone (GH) cut-off value for diagnosing growth hormone deficiency (GHD) in children is a subject of ongoing debate. With GH provocative tests typically using cut-offs between 4.7 and 6.5 µg/L, the traditional threshold of <10 µg/L is being reconsidered in favor of <7 µg/L due to advancements in GH assay standardization. Magnetic resonance imaging (MRI) of the pituitary gland is a crucial diagnostic tool,...

hrp0098p1-55 | GH and IGFs 1 | ESPE2024

The Relation Between Serum Glucose and Growth Hormone Concentrations During Standard Glucagon Test for GH Release in Short Stature Children

Hamed Noor , Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Ahmed Shayma , Zirak Hendeh , Elsiddig Sohair , Qusad Mohamed

Introduction: Glucagon serves as a growth hormone (GH) secretagogue. Serial measurements of GH concentration following glucagon administration are one of the growth hormone stimulation tests (GHSTs) for assessing GH sufficiency in children with suspected growth hormone deficiency (GHD). Although intramuscular glucagon is utilized to evaluate GH secretion, the relationship between changes in blood glucose (BG) and GH during this test has not been thoroughly stu...

hrp0098p2-93 | Fat, Metabolism and Obesity | ESPE2024

Prevalence of metabolic syndrome components and atherogenic index in obese nondiabeticchildren: anthropometric comparison with parents

Hamed Noor , Soliman Ashraf , Alyafei Fawzia , Ahmed Shayma , Alaaraj Nada , Shaat Mona , Bedair Abdelrahman

Background: The global prevalence of childhood and adolescent obesity has surged since 1980, reaching 107.7 million cases in 2015. Notably, 23% of children in developed countries are overweight or obese. The Atherogenic Index of Plasma (AIP) emerges as a novel, robust biomarker, closely linked to obesity, and serves as a reliable indicator of dyslipidemia and associated conditions, including cardiovascular diseases.Aim: ...

hrp0098p2-139 | GH and IGFs | ESPE2024

Postnatal Growth Patterns of Small for Gestational Age Infants Under 1.5 kg Over a Five-Year Period

Alyafei Fawzia , Soliman Ashraf , Abdulkayoum Anas , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Ali Hamdy

Background: Small for Gestational Age (SGA) infants, characterized by a birth weight below the 10th percentile for their gestational age, are susceptible to growth challenges. This longitudinal study investigates the postnatal growth of 10 SGA infants with birth weights under 1.5 kg, tracking their Weight-for-Age Z-score (WAZ), Length-for-Age Z-score (LAZ), and Weight-for-Length Z-score (WLZ) for five years.Methods: This...

hrp0098p2-140 | GH and IGFs | ESPE2024

Postnatal Growth Trajectories for 5 years for AGA Preterm Infants Born <1.5 kg.

Alyafei Fawzia , Soliman Ashraf , Abdulkayoum Anas , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Ali Hamdy

Background: Growth monitoring of Appropriate for Gestational Age (AGA) preterm infants is critical for the assessment of postnatal developmental progress and health outcomes. This study aims to delineate the postnatal growth patterns of AGA preterm infants with birth weights less than 1.5 kilograms, using Z-scores for length-for-age (LAZ), weight-for-age (WAZ), weight-for-length (WLZ), and head circumference-for-age (HCZ) over the first 60 months of life.<...

hrp0098p2-141 | GH and IGFs | ESPE2024

Insight into IGF1 Receptor Gene Mutations: Implications for Growth Disorders and Treatment - A Comprehensive Review

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Elsiddig Sohair , Adel Ashraf , Sabt Amal

Background: The growth and development of human tissues are critically regulated by the Insulin-like Growth Factor 1 Receptor (IGF1R) and its ligand IGF-1. Mutations in the IGF1R gene and less frequently in the IGF1 gene are associated with a heterogeneous group of growth disorders, manifesting as intrauterine and postnatal growth retardation.Literature Review: In this review, a total of 47 papers were analyzed, providin...

hrp0098p2-142 | GH and IGFs | ESPE2024

Comparative Study of Glucose Response to Intramuscular Glucagon in Pediatric Growth Hormone Deficiency and Idiopathic Short Stature: What is the risk of hypoglycemia?

Hamed Noor , Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Ahmed Shayma , Zirak Hendeh , Elsiddig Sohair , Qusad Mohamed

Background: The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is central to growth and metabolism. Growth hormone deficiency (GHD) in children can lead to metabolic disturbances and an increased risk of hypoglycemia. However, the response of blood glucose levels to glucagon in the presence of GHD compared to children with idiopathic short stature (ISS) is not well understood. This study aims to elucidate the glucose response to glucagon in thes...