ESPE Abstracts

Introduction: Klinefelter syndrome (KS) is the most common sex-chromosome disorder and cause of infertility and hypogonadism in males. However, KS remains an underdiagnosed condition with the majority of expected cases escaping clinical diagnosis and follow-up. Generally, the mid-puberty endocrine profile associated with KS is characterized by elevated levels of gonadotropins due to diminished testosterone feedback.Objective:</st...

Background: The average age at pubertal onset is declining worldwide which has received a lot of scientific and public attention. This secular trend is accompanied by an increasing number of children diagnosed with precocious puberty in many countries worldwide. However, there is less focus on the secular changes in the upper and lower boundaries (+/- 2 standard deviation (SD)) for pubertal onset and very little is known about whether a secular trend in the in...

Background: Linear growth during spontaneous puberty contributes approximately 20% to adult height in healthy subjects. The impact of gender-affirming hormone therapy (GAHT) on final height in transgender adolescents is sparsely studied.Aim: We aimed to investigate the growth and final height of Danish transgender adolescents.Methods: Our national cohort of transgender adolescents ...

Introduction: Klinefelter syndrome (KS, 47XXY) is the most frequent sex chromosome abnormality in males (prevalence 1/667), with tall stature as one of the key characteristics. We aimed to analyse growth patterns during different growth phases and adult height in KS using the QEPS-model.Methods: Longitudinal growth-data from 35 boys with KS followed at a tertiary Danish center for paediatric endocrinology were compared w...

Background and Aim: Despite the broad individual variation of pubertal maturation, references traditionally describe growth in relation to just chronological age and not biological age. Hence, growth references for the adolescent period have been of limited usefulness for monitoring individual growth in clinic and for research. Especially for children and adolescents with chronic diseases is there a need to better evaluate if changes in SD-scores just before a...

Background: Transgender adolescents may be treated with gender affirming hormone therapy (GAHT) consisting of gonadotropin-releasing hormone agonists (GnRHa) and cross-sex hormones. Limited data are available regarding the metabolic effects of GAHT in adolescence.Objective: To evaluate the lipid profiles and HbA1c in transgender adolescents after one year of cross-hormone treatment.Patients...

Background: Presence of current acne is well described in adolescents and adults with altered sex steroid levels, e.g., in polycystic ovarian syndrome, androgen producing tumors and misuse of anabolic androgenic substances. However, less is known about the impact of physiological concentrations of testosterone and dihydrotestosterone (DHT) quantified by gold standard LC-MS/MS methodologies on the development of acne in healthy adolescent boys and girls.<p ...

Background & Aim: The national Danish assessment and hormone treatment program for transgender adolescents started in 2016 and follows international guidelines. We aim to investigate the effects of hormone therapy on the sex steroid metabolite profile and gonadotropins.Methods: This observational study includes 219 transgender adolescents who started hormone therapy before 18 years of age comprising 55 individuals as...

Background: FSH stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. Age at pubertal onset varies substantially among healthy girls. Although more than half of the variation is heritable, only a small part has been attributed to specific genetic polymorphisms identified so far.Objective and Hypotheses: We assessed the effect on pubertal onset of three genetic polymorphisms affecting FSH action.<p...

Introduction: Management of children with adrenal disorders such as congenital adrenal hyperplasia involves thorough clinical monitoring, including measurements of plasma renin concentrations (PRC) and ACTH. However, sex- and age-related reference intervals (RIs) for PRC and ACTH using novel immunoassays are needed.Aim: To evaluate circulating concentrations of renin and ACTH in children and adolescents from the general ...