Previous issue | Volume 94 | ESPE2021

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

ePoster Category 2

Pituitary, neuroendocrinology and puberty

hrp0094p2-346 | Pituitary, neuroendocrinology and puberty | ESPE2021

The clinical and biochemical spectrum of pituitary lesions in children compared to adults: experience from a single tertiary center

Galazzi Elena , Carrara Silvia , Soranna Davide , Zambon Antonella , Maria Fatti Letizia , Moro Mirella , Persani Luca ,

We present a monocentric cross-sectional study of 55 children referred between 2000 and 2020 for pituitary lesions, who underwent a complete pituitary function assessment. These data were compared to results obtained in a group of 295 adults carrying pituitary lesions undergoing a complete pituitary screening. Follow-up data was available for 50 children and 248 adults. The mean age at diagnosis in children was 12.2±3.7 years (range 2.1-17.9), while in adults was 48.7&#17...

hrp0094p2-347 | Pituitary, neuroendocrinology and puberty | ESPE2021

Optic tract glioma and endocrine disorders- comparison between patients with and without NF1- a single center experience

Gil Margolis Merav , Yackobovitz-Gavan Michal , Toledano Hellen , Phillip Moshe , Shalitin Shlomit ,

Background and Aims: Optic pathway gliomas (OPGs) represent 2-5% of brain tumors in children. OPGs are classified by the anatomic location and whether they are associated with neurofibromatosis type 1 (NF1). Children with OPGs face sequelae related to tumor location and treatment modalities, including visual dysfunction, neurologic deficits, and endocrine dysfunction. The aim of our study was to assess the prevalence of endocrine dysfunctions in patients with ...

hrp0094p2-348 | Pituitary, neuroendocrinology and puberty | ESPE2021

Endocrine manifestations of paediatric intracranial germ cell tumour: from diagnosis to long-term follow-up

Partenope Cristina , Pozzobon Gabriella , Carceller Fernando , Albanese Assunta ,

Introduction: Endocrinopathies are common features of intracranial germ cell tumours (IC-GCTs), either as presenting symptoms caused by tumour itself or as side effects of treatments.Aims: We examined the development of endocrine dysfunctions in a cohort of paediatric patients with IC-GCTs at diagnosis and during follow up.Methods: We collected clinical, radiological, histopathological and hormonal...

hrp0094p2-349 | Pituitary, neuroendocrinology and puberty | ESPE2021

Machine learning to detect the Klinefelter syndrome endocrine profile

Madsen Andre , Aksglaede Lise , Juul Anders ,

Introduction: Klinefelter syndrome (KS) is the most common sex-chromosome disorder and cause of infertility and hypogonadism in males. However, KS remains an underdiagnosed condition with the majority of expected cases escaping clinical diagnosis and follow-up. Generally, the mid-puberty endocrine profile associated with KS is characterized by elevated levels of gonadotropins due to diminished testosterone feedback.Objective:</st...

hrp0094p2-350 | Pituitary, neuroendocrinology and puberty | ESPE2021

Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

Peng Junxiang , Boekhoff Svenja , Eveslage Maria , Bison Brigitte , Sowithayasakul Panjarat , Muller Hermann L. ,

Background: Severe obesity and tumor relapse/progression have impact on long-term prognosis in pediatric brain tumor patients.Methods: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on magnetic-resonance imaging (MRI) follow-up monitoring as a parameter for assessment of nuchal adipose tissue in 177 brain tumor patients (40 World Health Organization (WHO) grade 1–2 brain tumor; 31 grade 3&#1...

hrp0094p2-351 | Pituitary, neuroendocrinology and puberty | ESPE2021

Growth hormone deficiency in 52 children with brain Magnetic Resonance Imaging Abnormalities

Baz Ouidad , Lydia Chelghoum Imane , Kafi Imane , Kafi Salima , Mimouni Safia ,

Growth Hormone (GH) deficiency is the most common pituitary hormone deficiency in children. Magnetic Resonance Imaging (MRI) of the brain detects structural pituitary anomalies associated with GH deficiency. The prevalence of MRI abnormalities in patients with GHD, ranging from 25.9–100.0%. The Growth Hormone Research Society currently recommends that an MRI of the brain, with particular attention to the hypothalamic–pituitary region, should be carried out in any chi...

hrp0094p2-352 | Pituitary, neuroendocrinology and puberty | ESPE2021

Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory.

Salles Juliette , Franchitto Nicolas , Bieth Eric , Eddiry Sanaa , Molinas Catherine , Salles Jean Pierre , Tauber Maithe ,

Background: Prader-Willi syndrome is a rare genetic neurodevelopmental disorder caused by a paternal deficiency of maternally imprinted gene expression located in the chromosome 15q11-q13 region. Previous studies have demonstrated that several classes of neurodevelopmental disorders can be attributed to either over- or under-expression of specific genes that may lead to impairments in neuronal generation, differentiation, maturation and growth. Epigenetic chan...

hrp0094p2-353 | Pituitary, neuroendocrinology and puberty | ESPE2021

Clinical course of primary empty sella in children: a 10-year single-center experience

Besci Ozge , Yasar Elif , Mert Erbas Ibrahim , Yuksek Acinikli Kubra , Demir Korcan , Bober Ece , Abacı Ayhan ,

Background: Various studies, mostly conducted in adults, evaluated the hormonal axis in primary empty sella (PES), and reported different forms of pituitary deficiencies. We report our 10-year experience of pediatric cases with PES, investigating the pituitary function, associated impairments, and responses to treatments.Materials and Methods: We reviewed 10,560 cranial and 325 pituitary magnetic resonance imagings (MRIs) performed in ou...

hrp0094p2-354 | Pituitary, neuroendocrinology and puberty | ESPE2021

Relation between specific pubertal growth and breast maturation - a longitudinal study in healthy girls

Bergendahl Sophie , Niklasson Aimon , Stefan Aronson A. , Nierop Andreas F.M , Albertsson-Wikland Kerstin , Holmgren Anton ,

Background: Few studies have investigated in detail how the pubertal breast maturation in girls is related to the pubertal growth spurt in a longitudinal setting. The golden standard for assessment of secondary sex characteristics for girls includes breast development (B1-B5)1. The different maturation stages follow the increasing estradiol production from the ovaries also giving rise to the pubertal growth spurt. The QEPS-growth model makes it poss...

hrp0094p2-355 | Pituitary, neuroendocrinology and puberty | ESPE2021

Did Central Precocious Puberty Increase in COVID 19 Pandemic?

Orman Burce , Esen Senem , Keskin Meliksah , Sahin Nursel Muratoglu , Savas Erdeve Senay , Cetinkaya Semra ,

Background: The timing of puberty in children is occurring at an increasingly early age. During the COVID19 pandemic period, children experienced changes such as epidemic stress, sedentary life, and weight gain.Aim: To make a retrospective evaluation of the incidence of newly diagnosed central precocious puberty (CPP) during the first months of COVID-19. And to compare these corresponding data with the previousy ear....

hrp0094p2-356 | Pituitary, neuroendocrinology and puberty | ESPE2021

Delayed diagnosis of paediatric intracranial germ cell tumour (IC-GCTs)

Partenope Cristina , Pozzobon Gabriella , Carceller Fernando , Albanese Assunta ,

Introduction: Delays in diagnosis of IC-GCTs in the paediatric age have been frequently reported, affecting outcomes and prognosis.Aims: This study analysed clinical features of children with IC-GCTs treated at two European tertiary centres in the last 25 years. We retrospectively reviewed time lag between symptoms onset, radiological findings and definitive diagnosis of IC-GCT.Methods: Presenting ...

hrp0094p2-357 | Pituitary, neuroendocrinology and puberty | ESPE2021

Gonadotropin-releasing hormone analog treatment in children with idiopathic central precocious puberty: a pharmacovigilance study in a pediatric population.

Nasso Chiara , Cafarella Giulia , Visalli Giulia , Di Prima Elena , Squadrito Violetta , Squadrito Francesco , Altavilla Domenica , Aversa Tommaso , Wasniewska Malgorzata , Valenzise Mariella ,

Background: Central precocious puberty (CPP) results from premature activation of hypothalamic-pituitary-gonadal axis, which leads to an increased release of gonadotropin-releasing hormone (GnRH). GnRH stimulates the development of secondary sexual features, rapid bone maturation and growth. GnRH agonists (GnRHa) represent the gold-standard therapy in CPP children and their use is responsible for pituitary GnRH receptors down-regulation, luteinizing hormone (L...

hrp0094p2-358 | Pituitary, neuroendocrinology and puberty | ESPE2021

Pubertal induction in girls with hypogonadism: preliminary prospective data of efficacy in patients with/without initial overnight estrogen replacement

Rodari Giulia , Federici Silvia , Persani Luca , Arosio Maura , Bonomi Marco , Giavoli Claudia ,

Background: Pubertal induction in girls with hypogonadism through estrogen replacement therapy (ERT) aims at the development of secondary sexual characteristics, cognitive functions, uterine growth and maturation, bone mass accrual and linear growth. To date, the best induction regimen, capable of assuring both physiological gradual progression through Tanner stages and effective uterine development, is still to be established.Patients a...

hrp0094p2-359 | Pituitary, neuroendocrinology and puberty | ESPE2021

Evaluation of pituitary/cranial imaging results of central-puberty precocious cases

Nur Peltek Kendirci Havva , Kaba İlknur , Fidan Nurdan Fidan ,

Introduction: The activation of the GnRH pulse generator before the age of 8 years in girls and 9 years in boys results in central precocious puberty (CPP). The majority of cases of CPP in girls are defined as idiopathic since no organic lesion is found, whereas intracranial lesions are common in boys with CPP. Previous studies have shown that the height of the pituitary gland in the CPP cases is higher than in the normal children. We aimed to evaluate the pit...

hrp0094p2-360 | Pituitary, neuroendocrinology and puberty | ESPE2021

In vivo magnetic resonance spectroscopy as a non-invasive tool for the identification of a sellar tumour in a boy with precocious puberty.

Kosteria Ioanna , M. Gavra Maria , Vlachopapadopoulou Elpis-Athina , A. Verganelakis Dimitrios , Dikaiakou Eirini , Vartzelis Georgios , Michalakos Stefanos ,

Aim: To highlight the role of in-vivo magnetic resonance spectroscopy (MRS), as a non-invasive tool that can clarify the specific etiology of a sellar tumour in a boy with precocious puberty.Case presentation: A 4-year-old boy was admitted due to repeated episodes of focal seizures with fixed gaze, head turn to the right, and postictal drowsiness. Parents reported episodes of inappropriate laughter ("gelastic seizures") in the pr...

hrp0094p2-361 | Pituitary, neuroendocrinology and puberty | ESPE2021

Rahman Syndrome: Hypopituitarism might be responsible for changing height pattern

Betul Kaygusuz Sare , Turan Serap , Esen Nisa , Bereket Abdullah , Yesilyurt Ahmet , Guran Tulay ,

Objective: Histones have important structural and regulatory roles mediating the dynamic packaging of DNA. The dysregulation of histone modification leads to overgrowth syndromes, such as Sotos and Weaver syndrome. Recently heterozygous variants in HIST1H1E, which encodes linker histone H 1.4 has been associated with Rahman Syndrome, which is characterized by a very rare complex phenotype consisting of overgrowth, dysmorphism, and intellectual disabil...

hrp0094p2-362 | Pituitary, neuroendocrinology and puberty | ESPE2021

Congenital hypopituitarism: the role of genetics

Gil Poch Estela , Javier Arroyo Diez Francisco , Mendez Perez Pilar , Galan Gomez Enrique ,

Hypopituitarism refers to the insufficient secretion of one or more pituitary hormones. If default is present at the time of birth is called congenital hypopituitarism (CH). Causes of this are perinatal pathology and genetic alterations. The clinical presentation is heterogeneous. The diagnosis is made by clinical suspicion supported by hormonal determinations, brain imaging test (MRI) searching of structural defects and genetic study. The development of the pituitary gland is...

hrp0094p2-363 | Pituitary, neuroendocrinology and puberty | ESPE2021

Pedigree analysis is essential for clarifying oligogenic transmission in a family with congenital hypogonadotropic hypogonadism (CHH)

Oberhauser Sarah , Papadakis G Georgios , Pitteloud Nelly , L’Allemand Dagmar ,

Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare disease with a complex clinical picture and genetic background. In up to 50% genetic mutations are found. The goal is to be able to provide a comprehensive prognosis and genetic counseling for this family with CHH.Case presentation: At the age of 16 years a boy with familial constitutional delay (adrenarche only with 15 years, no growth spurt, bone age 14 years) present...

hrp0094p2-364 | Pituitary, neuroendocrinology and puberty | ESPE2021

Congenital hypogonadotropic hypogonadism associated with X-linked ichthyosis due to X-chromosome microdeletion identified by chromosomal microarray

Kokoreva Kristina , Chugunov Igor , Kalinchenko Natalia , Latyshev Oleg , Samsonova Lyubov , Bezlepkina Olga ,

Objective: to assess diagnostic usefulness and accuracy of different tools in patients with Kallmann syndrome and ichthyosis due to X-chromosome microdeletion.Materials: &scy;ongenital hypogonadotropic hypogonadism due to KAL1 pathological variants manifest with micropenis, cryptorchidism, delay of puberty, and not associated with disorder of sex development. This condition can be associated with ichthyosis due to deletion of X chromosome region with genes KAL...

hrp0094p2-365 | Pituitary, neuroendocrinology and puberty | ESPE2021

Gonadotropin Flare with Different Depot GnRH Agonists: Comparative Analysis.

Freire Analia , Arcari Andrea , Gabriela Ballerini Maria , Ignacio Bergada , Gabriela Ropelato Maria , Gryngarten Mirta ,

Central precocious puberty (CPP) is effectively treated by inhibition of GnRH signaling through GnRH receptor desensitization with depot GnRH agonists (dGnRHa), but the first injection is associated with a surge in LH and FSH (flare) that proportionally increases estradiol levels. When estradiol levels drop, usually within a fortnight, vaginal bleeding may be seen in a small number of girls. Although dGnRHa that use higher, longer-acting doses are increasingly being used in gi...

hrp0094p2-366 | Pituitary, neuroendocrinology and puberty | ESPE2021

Hypothalamic obesity in children with craniopharyngioma

Baz Ouidad , Achir Samia , Tazibt Oulebsir , Mimouni Safia ,

Introduction: Lesional hypothalamic obesity is most frequently attributable to craniopharyngiomas. The aim of our work is to describe the modalities of occurrence of this complication in a series of 27 children with craniopharyngioma followed in our center. We carried out a descriptive retrospective study of 27 cases of craniopharyngioma in children followed in the endocrinology department of the CPMC over a period of 16 years.Re...

hrp0094p2-367 | Pituitary, neuroendocrinology and puberty | ESPE2021

Duplication of Pituitary Gland-plus Syndrome presenting with a Transcranial Nasal Dermoid Cyst

Chandwani Manju , Spilioti Diamantina-Xanthi , Chumas Paul , Symth Alistair , Alvi Sabah , Nix Paul , Warren Daniel , Liddington Mark , Russell John , Elliott Mark ,

Duplicated pituitary gland in association with other midline craniofacial anomalies – also described as DPG-plus syndrome – is extremely rare. So far the only described endocrine associations are precocious or delayed puberty. We describe the multifaceted management of a female infant with DPG-plus syndrome. Interestingly, the patient also presented with trans-cranial nasal dermoid cyst and a nasal dimple with protruding hair, which has not been described in previous...

hrp0094p2-368 | Pituitary, neuroendocrinology and puberty | ESPE2021

Sterile Abscess Formation with Two Different GnRH Analogues: Three Case Reports

Karacan Kucukali Gulin , Ozalkak Şervan , Nur Peltek Kendirci Havva , Bostancı İlknur , Savas Erdeve Senay , Cetinkaya Semra ,

Introduction: Gonadotropin releasing hormone analogs(GnRHa) have been used safely for many years in the treatment of central precocious puberty(CPP).Although rare; pain, swelling, erythema at the injection site are known local side effects in patients receiving GnRHa treatment and are temporary.Sterile abscess(SA) development is also one of the rare local side effects.We presented three cases of treatment failure due to the development of SA after GnRHa therap...

hrp0094p2-369 | Pituitary, neuroendocrinology and puberty | ESPE2021

6-Month GnRHa Formulations Are a Good Choice During the COVID-19 Pandemic and Beyond

R. Benson Matthew , N. Atkinson Stuart , M. Boldt-Houle Deborah , Miller Bradley S. ,

Introduction: Achieving/maintaining effective hormone suppression is fundamental in treating Central Precocious Puberty(CPP). CPP patients are vulnerable to late dosing as they cannot self-administer and require clinic/hospital visits for injections, currently exacerbated by COVID-19. In children, the hypothalamic-pituitary-gonadal axis may rebound faster than elderly oncology patients, so hormone escapes are possible with late dosing. Additionally, the stimul...

hrp0094p2-370 | Pituitary, neuroendocrinology and puberty | ESPE2021

Size Matters: CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity

Hirtz Raphael , Libuda Lars , Hinney Anke , Focker Manuel , Buhlmeier Judith , Antel Jochen , Holterhus Paul-Martin , Kulle Alexandra , Kiewert Cordula , Hebebrand Johannes , Grasemann Corinna ,

Background: There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood. Moreover, the number of CAG repeats of the androgen receptor gene (AR) and the depression status (subclinical vs. overt depression) may modulate the role of testosterone, but this has not yet been studied in a clinical sample.Methods:...

hrp0094p2-371 | Pituitary, neuroendocrinology and puberty | ESPE2021

Is quail egg a potential endocrine disruptor?

Surekli Karakus Ozlem , Arabaci Tamer Sevil , Nisva Levent Hilal , Betul Kaygusuz Sare , Turan Serap , Akakin Dilek , Guran Tulay , Caglayan Yegen Berrak , Bereket Abdullah ,

Aim: Quail egg (QE) consumption became popular among children for alleged health benefits. Based on our observation of premature thelarche (PT) in a few children who consumed QE, we investigated the relationship between QE and puberty by a clinical and an experimental studies.Method: In the clinical study, a questionaire was used to compare the frequency and amount of QE consumption (between 55 girls with PT (n ...

hrp0094p2-372 | Pituitary, neuroendocrinology and puberty | ESPE2021

The impact of the Covid-19 pandemic on the UK National Hypothalamic-pituitary Axis Tumour (HPAT) multidisciplinary meeting

Bosch i Ara Laura , Spoudeas Helen , Wei Gan Hoong ,

Background: The HPAT multi-disciplinary meeting (MDT) was set up in 2011 with the aim to improve collaboration with other hospitals treating children with rare paediatric suprasellar brain tumours. It is a monthly remote meeting conducted virtually.Objective: To evaluate the impact of COVID19 pandemic by comparing the number of meetings, cases (news/previously discussed), diagnosis, attendees, specialties, centres and ou...

hrp0094p2-373 | Pituitary, neuroendocrinology and puberty | ESPE2021

Evaluation of Clinical, Laboratory and Radiological Findings in the Differential Diagnosis of Premature Telarche and Central Puberty Precocious

Nur Peltek Kendirci Havva , Kaba İlknur ,

Introduction and Aim: Central puberty precocious (CPP) is defined as the development of secondary sex characters due to the activation of the hypothalamus-pituitary-gonad axis before the age of eight in girls. Premature telarche (PT) is defined as isolated breast development in girls without other findings of puberty. We aimed to evaluate the clinical, laboratory and radiological findings used in the differential diagnosis of PT and CPP....

hrp0094p2-374 | Pituitary, neuroendocrinology and puberty | ESPE2021

Crooke Cell Adenoma as a Rare Cause of Recurrent Cushing Disease: A Challenge in Treatment and Follow-up

Jalilova Arzu , Ozen Samim , Callı Cem , Ozgiray Erkin , Ertan Yeşim , Gokşen Damla , Darcan Şukran ,

Introduction: Crooke’s cell adenoma (CCA) is an aggressive subtype of corticotroph adenoma, it is usually large, frequently invades surrounding tissues, and is resistant to both surgery and radiotherapy.Case Report: A 13-year-old girl, admitted with weight gain for more than 3 months. Her height was 147.5 cm (-1.5 SDS), weight 58.5 kg (1.1 SDS), BMI 26.89 kg/m2 (2 SDS) and blood pressure was 100/78mmHg. Her i physical exa...

hrp0094p2-375 | Pituitary, neuroendocrinology and puberty | ESPE2021

Salivary sex steroids as markers of puberty in boys during late childhood and adolescence

Patjamontri Supitcha , Spiers Alexander , Smith Rachel B , Shen Chen , Adaway Jo , G Keevil Brian , Toledano Mireille B , Ahmed S Faisal ,

Introduction: Salivary androgens represent a non-invasive marker of puberty that may have utility in population studies as well as in the clinical arena.Objectives: To establish normal reference values of salivary androgens using LC-MS/MS and demonstrate the correlations between salivary androgens and pubertal development in boys.Methods: School-based adolescent cohort study with t...

hrp0094p2-376 | Pituitary, neuroendocrinology and puberty | ESPE2021

Efficacy of cabergoline in the treatment of pituitary macroadenoma complicated in a 14-year-old girl.

Jamal Anouar , Benyakhlef Salma , Aymane Loukili Mohamed , Rbiai Najoua , Rouf Siham , Latrech Hanane ,

Introduction: Pituitary adenomas in children are rare and account for 3% of intracranial tumors in the pediatric population (1), dominated by prolactinomas and corticotropic adenomas, but plurisecreting adenomas are exceptional. We report a case of a 14-year-old girl with a pituitary macroadenoma with a prolactin-predominant plurisecretory immunohistochemical profile revealed by an intracranial hypertension syndrome with a good therapeutic response to cabergol...

hrp0094p2-377 | Pituitary, neuroendocrinology and puberty | ESPE2021

Use of Tolvaptan in a child with SIADH post pituitary surgery

Lohiya Nikhil , Didi Mohamed , Senniappan Senthil ,

Introduction: Post-operative management of fluid and electrolyte imbalance after surgery for pituitary or suprasellar tumors could be challenging. Post-operative course could include diabetes insipidus (DI) (transient or permanent) or a classical triphasic response (initial phase of DI followed by a second phase of transient SIADH and third and final phase of permanent DI). Mainstay of management of SIADH in these patients involves fluid restriction. At times,...

hrp0094p2-378 | Pituitary, neuroendocrinology and puberty | ESPE2021

The effect of 3 years of Gonadotropin-Suppressive Therapy in Girls with Early Puberty: Height Z Score in Relation to Mid-Parental height Z score.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma , Alyafei Fawzia ,

Introduction: Early and fast puberty (EFP) in girls, defined as pubertal onset at age 8-9 yr., with an accelerated course, may cause compromised final adult height (FAHt). Treatment with a gonadotropin-suppressive agent is still controversial because the improvement in FAHt is equivocal and there may be a risk of overweight.Aim of the study: We analyzed the data of 24 girls with EFP treated with GnRH analog (GnRH) since Tanner stage 2-3,...

hrp0094p2-379 | Pituitary, neuroendocrinology and puberty | ESPE2021

An Observational, Retrospective Study to Evaluate Long Term Safety and Effectiveness of Leuprorelin in the Treatment of Central Precocious Puberty

Fu Junfen , Dong Guanping , Li Pin , Gong Yan , Yang Yu , Yang Li , Gu Wei , Yuan Xuewen , Luo Xiaoping , Hou Ling , Zhong Yan , You Cheng , Wang Winston , Guo Ziheng ,

Objectives: To describe safety and effectiveness of high (≥90-180 µg/kg) and low (<90-30 µg/kg) dose leuprorelin in treating central precocious puberty (CPP).Methods: In this observational, retrospective study, effectiveness was evaluated based on regression or no progression of Tanner staging as the primary outcomes. LH, FSH, estradiol or testosterone suppression, and decrease in bone age to chronolo...

hrp0094p2-381 | Pituitary, neuroendocrinology and puberty | ESPE2021

Characterization of puberty development in a large cohort of patients with Noonan syndrome with molecular diagnosis

Rezende Raissa , Jorge Alexander , Noronha Renata , Keselman Ana , Andrade Nathalia , Dantas Naiara , Bertola Debora , Malaquias Alexsandra ,

Introduction: Noonan syndrome (NS) is a relative frequent genetic disorder, mainly characterized by dysmorphic face features, congenital heart defects and short stature. Though delayed pubertal development has been described in both sexes, the physiopathological root remains unclear. This study aims at characterizing puberty development in Noonan syndrome.Materials and Methods: The study population included 111 individuals with a molecul...

hrp0094p2-382 | Pituitary, neuroendocrinology and puberty | ESPE2021

Pituitary tumors in children and adolescents: clinical and etiological profile

Bouichrat Nisrine , Messaoudi Najoua , Zerrouki Dounia , Rouf Siham , Latrech Hanane ,

Introduction: Pituitary tumors are rare in children and adolescents. The etiology is dominated by craniopharyngiomas. The main clinical presentation is the tumoral syndrome. These lesions often affect growth and pubertal development. The objective of our work is to study the clinical and etiological characteristics of pituitary tumors in the pediatric population.Materials and Methods: This is a retrospective descriptive study involving 0...

hrp0094p2-383 | Pituitary, neuroendocrinology and puberty | ESPE2021

Langerhans Cell Histiocytosis with Isolated Central Diabetes Insipidus, Low Grade Fever and Sellar Erosion

OKUR Iclal , ARI Hasan , Cetinkaya Semra , Emine Derinkuyu Betul , Caglar Gizem , Gokce Cinar Hasibe , Yesil Sule , Savas-Erdeve Senay ,

Introduction: The annual incidence of Langerhans cell histiocytosis (LCH) is 5 per million in admission with a diagnosis of isolated central diabetes insipidus (CDI) in children under the age of 15. Here, the process leading to the diagnosis of LCH at presentation with isolated CDI, imaging findings, and the sellar erosion, which has not been previously reported in the literature, will be discussed.Case presentation: A 4-year-5-month-old...

hrp0094p2-384 | Pituitary, neuroendocrinology and puberty | ESPE2021

Basal LH as a screening test for diagnosis of central precocious puberty

Raafat Shaymaa , Abdelmeguid Yasmine , Fawzy Dina ,

Introduction: Central precocious puberty (CPP) refers to the development of secondary sex characteristics before ages 8 and 9 years in girls and boys, respectively. It is either due to organic brain lesion or idiopathic. Conventionally, Gonadotropin Releasing Hormone (GnRH) stimulation test is a mainstay tool for diagnosis of central precocious puberty in pediatrics. However, it is time consuming and expensive. Therefore, this study was aiming to find an alter...

hrp0094p2-385 | Pituitary, neuroendocrinology and puberty | ESPE2021

A Practical Method for the Evaluation of Childhood Hypophysitis: Pituitary Stalk/Basilary Artery Ratio

Torel Ergur Ayca , Şimşek Fatma , Arslan Kubra , Ali Yinanc Mehmet ,

Introduction: Childhood hypophysitis (CH) is an extremely rare entity that has difficulties in definition and displays a wide variety of symptomatology. The volume and shape of pituitary gland may increase in physiological periods such as puberty and pregnancy, it may also change in various neuroendocrine and psychiatric diseases. It is important to distinguish physiological changes observed in the pituitary, especially in puberty, from hypophysitis.F...

hrp0094p2-386 | Pituitary, neuroendocrinology and puberty | ESPE2021

Blood Pressure in Girls with Central Precocious Puberty and GnRH Analog Therapy

Fisch Shvalb Naama , Harani Hadas Alfandary , Davidovits Miriam , Shvalb Nir , Demol Eliaz Sharon , Yackobovitch Gavan Michal , Phillip Moshe , de Vries Liat ,

Objectives: Several case reports describe hypertension (HTN) in children treated with GnRH analogs for central precocious puberty (CPP). However, relevant data on blood pressure (BP) under GnRH analog treatment are scarce. We evaluated BP among girls with idiopathic CPP and early puberty (EP) before, during and after GnRH analog therapy, and examined associations of BP with clinical parameters.Design: A retrospective longitudinal cohort ...

hrp0094p2-387 | Pituitary, neuroendocrinology and puberty | ESPE2021

Isolated central diabetes insipidus and periventricular nodular heterotopia in a 9-year-old girl

Haufler Florentina , Walleczek Nina-Katharina , Vodopiutz Julia , Haeusler Gabriele , Raimann Adalbert ,

Background: Periventricular nodular heterotopia (PNH) is a brain malformation caused by dysregulation of neuronal migration during cerebral development, resulting in nodular neuronal structures in the ventricular surface. Associated ectopy of the posterior pituitary has been reported in literature and is usually associated with deficiencies of the anterior pituitary. The occasion of an isolated central diabetes insipidus due to absence of the posterior pituita...

hrp0094p2-388 | Pituitary, neuroendocrinology and puberty | ESPE2021

Central precocious puberty: clinical, etiologic and therapeutic features

Assarrar Imane , Derkaoui Nada , Rami Imane , Rouf Siham , Latrech Hanane ,

Introduction: Precocious puberty is defined by the apparition of secondary sexual features before the age of 8 years in girls and 9.5 years in boys. Central precocious puberty (CPP) results from a premature activation of the hypothalamic-pituitary-gonadal axis. The aim of this study is to review the clinical, etiologic and therapeutic features of this entity.Patients and methods: It is a descriptive retrospective study including 7 patien...

hrp0094p2-389 | Pituitary, neuroendocrinology and puberty | ESPE2021

Atypical Presentation of Pituitary Macroadenoma in an adolescent girl: Central Hypothyroidism and Attenuated Pubertal Growth Spurt.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma ,

Introduction: Hyperprolactinemia (HPrl) secondary to macroadenoma is a rare endocrinopathy in childhood but represents one of the most frequent forms of pituitary adenoma.Case report: A 12yr old girl was referred for assessment of progressive weight gain in the last 1.5 years. Despite trials of weight control by changing the dietary habit and daily exercise weight her BMI SDS increased from 1.2 to 2.2. This was associated with progressiv...

hrp0094p2-390 | Pituitary, neuroendocrinology and puberty | ESPE2021

A case of partially Empty Sella with hypopituitarism in a child

Pratap Rajat , Mason Leah , Basu Supriyo ,

Introduction: Empty Sella (ES) is a radiological finding which is due to herniation of subarachnoid space into sella turcica. It’s partial, when <50% space is filled with cerebrospinal fluid (CSF) and complete, when CSF fills >50% with pituitary gland flattened to <=2mm. Actual occurrence is debatable and often noted incidentally during magnetic resonance imaging (MRI). However, it can cause pituitary hormone (PH) dysfunctions, most commonly g...

hrp0094p2-391 | Pituitary, neuroendocrinology and puberty | ESPE2021

Cushing’s disease in paediatric patients: Diagnosis and evolution

Messaoudi Najoua , Assarrar Imane , Bouichrat Nisrine , Karrou Marouan , Rouf Siham , Latrech Hanane ,

Introduction: Cushing’s syndrome is rare in the paediatric population, affecting 0.89 per million children between the ages of 0 and 20 years. The causes of Cushing’s syndrome of endogenous origin are dominated by pituitary causes in 70-95%, with a peripubertal revelation. We report the case of a child followed for Cushing’s disease in the department of Endocrinology-Diabetology-Nutrition of Mohammed-VI University Hospital Center of Oujda, in th...

hrp0094p2-392 | Pituitary, neuroendocrinology and puberty | ESPE2021

Late Puberty In Children

Asmae Touzani , Mohamed Boualam , Nouzha Rami , Yamna Kriouile , Zineb Imane , Abdellah Dami , Lhoucin Balouch , Ahmed Gaouzi ,

Objectives: This retrospective and descriptive study aim to study the frequency of children who have a pubertal delay and who are followed at the Department of Pediatrics II at the Children’s Hospital of Rabat. Materials and Methods: Among 1850 records collected, 24 patient records that meet the criteria for inclusion. A delay in the appearance of sexual characters: the lack of breast development after the age of 13.5 years in the girl and the lack of inc...

hrp0094p2-393 | Pituitary, neuroendocrinology and puberty | ESPE2021

First Morning Voided Urinary Gonadotropin Measurements for the Early Screening, Diagnosis and Follow-up of Central Precocious Puberty Patients

Ye Feng , Luo Xiaoping , Dong Guoqing , Chen Ruimin , Dong Zhiya , Lu Wenli , Fu Junfen , Zhan Shumin , Luo Feihong , Gong Chunxiu , Wei Liya , Yang Yu , Zhu Min , Ma Huamei , Chen Qiuli , Cheng Xinran , Gou Peng ,

Central precocious puberty (CPP) is one of the most common pediatric endocrine diseases with an ever increasing incidence. CPP is associated with the loss of final adult height, early menarche, psychological problems and an increased risk of developing diseases in later adulthood such as female reproductive system tumors. The gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard for the diagnosis of CPP. However, the test is costly and time consuming to...