ESPE Abstracts

Introduction and Aim: Central puberty precocious (CPP) is defined as the development of secondary sex characters due to the activation of the hypothalamus-pituitary-gonad axis before the age of eight in girls. Premature telarche (PT) is defined as isolated breast development in girls without other findings of puberty. We aimed to evaluate the clinical, laboratory and radiological findings used in the differential diagnosis of PT and CPP.

Material and Method: The study included girls accompanied of breast development before age of 8 and diagnosed with CPP or PT. Patients’ calendar age, bone age, bone age/calendar age ratio, anthropometric variables, puberty stages, LH, FSH and Estrodiol levels, ovarian and uterine volumes were examined retrospectively.

Results: The study included sixty-five girls 53.8 % PT (n = 35) and 46.2% CPP (n = 30). Height SD values (P = 0.008), basal LH, FSH and estrodiol levels (P = 0.029, P = 0.008, P = 0.011, respectively), right and left ovaries and uterine volumes (P = 0.030, P = 0.008, P = 0.039 respectively) bone age (P = 0.039), and bone age/calendar age ratios (P = 0.024) were found different between two groups. The importance order of the parameters used in the differential diagnosis of CPP and PT was found as basal LH level, ovarian volume, height SD value, and estrodiol level.

Conclusion: In our study, our patients with CPP were taller than their peers with PT, had higher LH, FSH and estrodiol levels, larger ovarian and uterine volumes, higher bone ages and higher bone age/calendar age. We found that the most important parameter in diagnosis was basal LH level.