ESPE Abstracts (2021) 94 P2-350

1Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangzhou, China; 2Department of Pediatrics, University Children’s Hospital, Klinikum Oldenburg, Oldenburg, Germany; 3Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany; 4Department of Neuroradiology, University Hospital Würzburg, Würzburg, Germany; 5Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand

Background: Severe obesity and tumor relapse/progression have impact on long-term prognosis in pediatric brain tumor patients.

Methods: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on magnetic-resonance imaging (MRI) follow-up monitoring as a parameter for assessment of nuchal adipose tissue in 177 brain tumor patients (40 World Health Organization (WHO) grade 1–2 brain tumor; 31 grade 3–4 brain tumor; 106 craniopharyngioma), and 53 healthy controls. Furthermore, body mass index (BMI), waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood pressure were analyzed for association with NST.

Results: Craniopharyngioma patients showed higher NST, BMI, WHtR, and cSFT when compared to other brain tumors and healthy controls. WHO grade 1–2 brain tumor patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 brain tumor patients. NST correlated with BMI, WHtR, and cSFT. NST, BMI and WHtR were associated with increased blood pressure. In craniopharyngioma patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased.

Conclusions: NST could serve as a novel useful marker for regional nuchal adipose tissue. NST is highly associated with body mass and waist-to-height ratio, and easily measurable in routine MRI monitoring of brain tumor patients.

Volume 94

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

European Society for Paediatric Endocrinology 

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