hrp0098p2-9 | Adrenals and HPA Axis | ESPE2024

The Role of Midkin and Inflammatory Cytokines in The Pathophysiology of Metabolic Syndrome in Children and Adolescents with Classical Congenital Adrenal Hyperplasia Due to 21 Hydroxylase Enzyme Deficiency.

Çetinkaya Semra , Kesikli Burcu , Ayral Arıbal Pelin , Yazıhan Nuray

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase(21-OH) deficiency is the most common type of CAH. In the treatment, the insufficinet hormones are replaced. The excess doses cause hypercortisolism, insufficient doses; causes hyperandrogenism. Both metabolic conditions; It has been found to be associated with comorbidities that increase the risk of cardiovascular disease. Here, it is aimed to determine the comorbidities that increase the risk of cardiovascular disease...

hrp0082p2-d1-590 | Thyroid | ESPE2014

Thyroid Disorders in Siblings of CH Patients with Thyroid Dysgenesis

Cassio Alessandra , Ruscio Valentina Di , Baronio Federico , Bettocchi Ilaria , Cantasano Antonella , Bal Milva Orquidea , Balsamo Antonio , Maltoni Giulio , Mazzanti Laura

Background: Thyroid dysgenesis has been considered a sporadic disease, but recent observations suggested a possible genetic basis.Objective and hypotheses: The aim of our report is to evaluate the incidence of hormonal and ultrasound thyroid anomalies in siblings of CH patients with thyroid dysgenesis.Method: In Emilia-Romagna Region (Italy) 328 CH infants were diagnosed by neonatal screening between January 2000 and December 2012....

hrp0082p2-d1-593 | Thyroid | ESPE2014

Incidence of Thyroid Nodules in Children Affected by Hashimoto’s Thyroiditis: a 12-Year Survey of 567 Children

Longhi Silvia , Aversa Tommaso , Bal Milva , Cantasano Antonella , Cappa Marco , Cassio Alessandra , Corrias Andrea , D'Antonio Valeria , De Luca Filippo , Di Mase Raffaella , Gastaldi Roberto , Guzzetti Chiara , Loche Sandro , Salerno Mariacarolina , Maria Tronconi Giulia , Cristina Vigone Maria , Weber Giovanna , Radetti Giorgio

Background: Hashimoto’s thyroiditis (HT) has been linked to papillary cancer in adults but not in children and adolescents. Moreover, there is no agreement on the more appropriate frequency of thyroid ultrasound (TS) in the follow-up of children with HT.Objective and hypotheses: The aim of the study was to investigate the incidence of thyroid nodules and of thyroid cancer in a large group of children and adolescents (567) with HT followed-up for a m...

hrp0098p2-285 | Thyroid | ESPE2024

Levothyroxine poisoning in children is usually benign: A multi-center experience from Turkey

Şen Küçük Kübra , Demir Şule , Deveci Sevim Reyhan , Akgül Fatma , Yalçın Gülşen , Eser Öznur , Bal Alkan , Ergün Elif , Öztürk Sercan , Anık Ahmet

Objective: The objective of this study was to investigate the clinical presentations, laboratory findings, treatment modalities, follow-up strategies employed for children with levothyroxine (LT4) poisoning.Materials-Methods: The study encompassed patients admitted to the respective centers between 2010-2023, who fulfilled the predefined study criteria. Findings were presented as percentages (%), median values with inter...