Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

hrp0082p2-d1-584 | Thyroid | ESPE2014

Treatment of Pediatric Graves’ Disease: Results of a Multicenter Survey in Portugal

Marques Olinda , Joao Oliveira Maria , Antunes Antunes Ana , Espada Filipa , Guimaraes Joana

Background: In 2011, ATA and AACE published Guidelines on pediatric Graves’ disease (GD) treatment. Nevertheless it is still a controversy.Objective and hypotheses: SPEDP conducted the first nationwide questionnaire survey among all the Endocrinologists and Pediatricians in the Portuguese Public Health System Hospitals about pediatric GD treatment in order to know the reality in our country.Method: SPEDP designed and distribut...

hrp0082p2-d1-585 | Thyroid | ESPE2014

Subclinical Hypothyroidism is Associated with Low IGF1 Levels and Decreased Growth Velocity

Bellini Helena , Maciel Lea , Custodio Rodrigo , Milani Soraia , Paula Mariana , Antonini Sonir , Liberatore Raphael , Martinelli Carlos

Background: Subclinical hypothyroidism (SH) is defined as normal tyrosine levels in the presence of TSH concentrations between 5 and 10 mU/ml. The impact of SH on IGF system and growth of infants remains unknown.Objective and hypotheses: To evaluate IGF1, IGFBP3 levels and growth velocity (GV) of infants with SH.Method: 98 children up to 36 months of age, recalled due to a TSH >5 mU/ml in the neonatal screening test, were divid...

hrp0082p2-d1-586 | Thyroid | ESPE2014

Thyroid Function and Autoimmunity and Their Relation to Weight Status in Healthy Children and Adolescents

Garcia-Garcia Emilio , Galera-Martinez Rafael , Garcia-Escobar Iciar , Oliva-Perez Patricia , Gomez-Llorente Jose L. , Momblan Jeronimo , Vazquez-Lopez Maria A. , Perales Antonio Bonillo

Background: The interrelationships between body weight and thyroid status are complex. Serum TSH is typically increased in obese compared with lean individuals. Several mechanisms leading to hyperthyrotropinemia have been hypothesized.Objective and hypotheses: To compare thyroid function and autoimmunity in normal, overweight and obese healthy children and adolescents in our population. To analyse any metabolic risk factor related to hyperthyrotropinemia...

hrp0082p2-d1-587 | Thyroid | ESPE2014

Mutation of the TSH Receptor Gene: a Longitudinal Study in Children with Non-Autoimmune Subclinical Hypothyroidism

Vigone Maria Cristina , Sonnino Micol , Guizzardi Fabiana , Frenna Marianna Di , Caiulo Silvana , Gelmini Giulia , Persani Luca , Weber Giovanna

Background: Neonatal screening strategies revealed an increase in hypothyroidism associated with an in-situ thyroid gland due to TSH receptor (TSHR) mutations. While there are many genetic and functional studies regarding TSHR mutations, few are found concerning the clinical course and long-term outcome of TSH resistance involving the pediatric population.Objective and hypotheses: To determine the impact of TSHR mutations on clinical course, biochemical ...

hrp0082p2-d1-588 | Thyroid | ESPE2014

Investigation of Autoimmune Diseases Accompanying Hashimoto’s Thyroiditis in Children and Adolescents and Evaluation of Cardiac Signs

Bas Veysel Nijat , Agladioglu Sebahat Yilmaz , Ozgur Senem , Karademir Selmin , Aycan Zehra

Objective: In the present study, it was aimed to investigate the concomitance of additional cardiac problems, mainly mitral valve prolapse, in adolescents and pediatric patients with Hashimoto’s thyroiditis, by screening autoimmune markers.Methods: Euthyroid 57 patients, who applied to the Pediatric Endocrinology clinic at our institution with marked symptoms of hypothyroidism at the time of diagnosis, and were diagnosed and treated for Hashimoto&#1...

hrp0082p2-d1-589 | Thyroid | ESPE2014

No Difference in Cognitive Development of Young Adults and Adolescents Affected by Congenital Hypothyroidism Compared to Their Sibling Controls Despite High Dose L-Thyroxin Treatment

Aleksander Paulina , Blankenstein Oliver , Gruters Annette , Krude Heiko

Background: An early diagnosis and treatment based on neonatal screening offers a normal cognitive development in patients affected with congenital hypothyroidism (CH). However, several studies within cohorts of young adults have shown a still existing difference compared to control groups of up to eight IQ points. Moreover it has been claimed recently that a high L-T4 dose with subsequent episodes of overtreatment results in less favourable IQ outcom...

hrp0082p2-d1-590 | Thyroid | ESPE2014

Thyroid Disorders in Siblings of CH Patients with Thyroid Dysgenesis

Cassio Alessandra , Ruscio Valentina Di , Baronio Federico , Bettocchi Ilaria , Cantasano Antonella , Bal Milva Orquidea , Balsamo Antonio , Maltoni Giulio , Mazzanti Laura

Background: Thyroid dysgenesis has been considered a sporadic disease, but recent observations suggested a possible genetic basis.Objective and hypotheses: The aim of our report is to evaluate the incidence of hormonal and ultrasound thyroid anomalies in siblings of CH patients with thyroid dysgenesis.Method: In Emilia-Romagna Region (Italy) 328 CH infants were diagnosed by neonatal screening between January 2000 and December 2012....

hrp0082p2-d1-591 | Thyroid | ESPE2014

Trends in Median Age at Guthrie Sampling, Laboratory Receipt, Notification, and Start of Treatment for Infants with TSH Elevation on Newborn Screening

Mansour Chourouk , Ouarezki Yasmine , Jones Jeremy , Smith Sarah , Donaldson Malcolm , Mason Avril

Background: Screening for congenital hypothyroidism (CH) has virtually eradicated the severe mental handicap associated with late or absent treatment. We have previously reported two audits of newborn screening for CH between 1979 and 2003 showing significant improvement from the first to more recent period.Objective and hypotheses: We aimed to audit the period 2004–2013 and report trends in timing of sampling, laboratory processing, delay between f...

hrp0082p2-d1-592 | Thyroid | ESPE2014

Iodine-Deficiency Levels in Schoolchildren Aged Between 6 and 12

Munoz-Serrano Ana , Gonzalez-Gonzalez Abel , Maria Tenias-Burillo Jose , Falero-Gallego Piedad , Canete Ramon

Background: Iodine deficiency is the main cause of endemic goitre. A total of 29.8% of the world’s school-age children insufficient iodine intake. A population is deemed iodine-sufficient when median iodine levels are over 100 μg/l; measured iodine deficiency serves as a diagnostic criterion for determining the extent to which goitre is endemic, and also as an indicator of the gradual eradication of iodine-deficiency disorders.Patients, materia...

hrp0082p2-d1-593 | Thyroid | ESPE2014

Incidence of Thyroid Nodules in Children Affected by Hashimoto’s Thyroiditis: a 12-Year Survey of 567 Children

Longhi Silvia , Aversa Tommaso , Bal Milva , Cantasano Antonella , Cappa Marco , Cassio Alessandra , Corrias Andrea , D'Antonio Valeria , De Luca Filippo , Di Mase Raffaella , Gastaldi Roberto , Guzzetti Chiara , Loche Sandro , Salerno Mariacarolina , Maria Tronconi Giulia , Cristina Vigone Maria , Weber Giovanna , Radetti Giorgio

Background: Hashimoto’s thyroiditis (HT) has been linked to papillary cancer in adults but not in children and adolescents. Moreover, there is no agreement on the more appropriate frequency of thyroid ultrasound (TS) in the follow-up of children with HT.Objective and hypotheses: The aim of the study was to investigate the incidence of thyroid nodules and of thyroid cancer in a large group of children and adolescents (567) with HT followed-up for a m...

hrp0082p2-d1-594 | Thyroid | ESPE2014

The Evolution of Iodine Status in Schoolchildren Living in a Formerly Iodine-deficient Region of Mures County, Romania

Szanto Zsuzsanna , Reti Zsuzsanna , Ballok Jolan , Csiszer Attila , Nagy Elod , Kun Ildiko , Zoltan Kun Imre

Background: Some hilly-mountainous regions of Mures County, located in the geographical center of Romania, were known as moderately mild iodine-deficient areas before the universal use of iodized alimentary salt was compulsorily implemented in practice in 2003. A partial evaluation was performed in 2006, but the sustainability of this prophylactic program was not evaluated afterward.Objective and hypotheses: To assess the current iodine status of schoolc...

hrp0082p2-d1-595 | Thyroid | ESPE2014

Papillary Thyroid Cancer with Diffuse Pulmonary Metastasis: How to Manage?

Bas Serpil , Abali Saygin , Gokdemir Yasemin , Haliloglu Belma , Atay Zeynep , Karadag Bulent , Bereket Abdullah , Turan Serap

Background: Papillary thyroid cancer (PTC) is the most common endocrine malignancy in children. PTC shows more aggressive progress in children than in adults in respect to local and distant metastases. Here we presented a PTC case with primary pulmonary symptoms and pulmonary metastasis.Case: A 15.5-year-old male patient presented to the clinics with cyanosis and respiratory difficulty for the last 2 years. He had dyspnea, central cyanosis, clubbing, and...

hrp0082p2-d1-596 | Thyroid | ESPE2014

Factors Useful to Distinguish between Children with Permanent Congenital Hypothyroidism and Transient or Permanent Hyperthyrotropinemia

Francesca Messina Maria , Ramistella Vincenzo , Aversa Tommaso , Valenzie Mariella , De Luca Filippo

Background: Screening for congenital hypothyroidism (CH) with the possibility of an early treatment has transformed the outlook for children with CH. Despite the unquestioned public health success of newborn screening programs, the management of CH is still controversial. Most patients with positive screening have permanent hypothyroidism but some of them may have transient hyperthyreotropinemia, so it is important to identify these patients in order to avoid lifelong unnecess...