Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 2

Thyroid (1)

hrp0082p2-d2-597 | Thyroid (1) | ESPE2014

Thyroid Nodules in Childhood and Adolescence; Clinical, Radiologic and Etiological Evaluation

Evliyaoglu Olcay , Ozcabi Bahar , Tekin Ayse , Bucak Feride , Ercan Oya

Background: Thyroid nodules are less common in childhood but it has higher risk of malignancy. In this study, we aimed to evaluate children and adolescents with thyroid nodules, clinically, radiologically and histopathologically to determine etiologic distrubution.Method: Seventy-one patients (46 females) with the mean age of 10.41±5.03 (0.04–21) years with thyroid nodules were involved in this study. Patients were evaluated by their complaints...

hrp0082p2-d2-598 | Thyroid (1) | ESPE2014

An Unusual Presentation of Acquired Hypothyroidism: the Van Wyk–Grumbach Syndrome

Isguven Pinar , Uluc Nefise , Kosecik Mustafa , Karacan Mehmet , Ermis Bahri

Background: Van Wyk–Grumbach syndrome (VWGS) is characterized by breast development, uterine bleeding and multi-cystic ovaries in the presence of long-lasting primary hypothyroidism.Objective and hypotheses: The pathophysiology of VWGS involves a complex mechanism, which is at least partly mediated by the direct action of TSH and FSH receptors.Method: We present a girl with Down syndrome having typical feature...

hrp0082p2-d2-599 | Thyroid (1) | ESPE2014

Severe Urticaria in Graves’ Disease: is Carbimazole to Blame?

Ponmani Caroline , Mcclatchey Martin , Kanzaria Shilpa , Keane Morgan , Banerjee Kausik

Background: Carbimazole is widely used in the treatment of Graves’ disease and is well tolerated but can produce adverse effects in 5% of cases. Urticaria, which can develop as a drug reaction to carbimazole responds to withdrawal of the drug and symptomatic management. Urticaria is also a rare manifestation of thyrotoxicosis and does not respond to treatment, but regresses rapidly with the control of underlying hyperthyroidism.Objective and hypothe...

hrp0082p2-d2-600 | Thyroid (1) | ESPE2014

Low Serum Free T4 Concentration in a Girl with McCune-Albright Syndrome

Peet Aleksandr , Roosimaa Mart , Pajuvali Anett , Tillmann Vallo

Background: McCune–Albright syndrome (MAS) is a rare disease with a prevalence of <1 to 100 000. It is caused by early post-zygotic mutations in the GNAS1 gene. Classically it presents with precocious puberty, fibrous dysplasia and café-au-lait spots. Other endocrinopathies may be hyperthyroidism, GH excess, Cushing syndrome, and renal phosphate wasting.Case report: A 17-year-old girl diagnosed with MAS at the age of 11 on basis of all thre...

hrp0082p2-d2-601 | Thyroid (1) | ESPE2014

Long Term Anti-Thyroid Drug Therapy in a Paediatric Population with Down Syndrome: an Irish Experience

Johnston Niall , Mavinkurve Meenal , Murphy Nuala , Moloney Sinead , Costigan Colm , Cody Declan

Background: Ireland has the highest prevalence of Down syndrome (DS) in Europe, affecting ~1 in 500 live births. Patients with DS are at increased risk of developing thyroid disorders during childhood. Hyperthyroidism can be difficult to recognise and treat in this population. First-line therapy with anti-thyroid drugs (ATDs) may help achieve remission, but relapse is common following discontinuation of medication. Definitive treatment with radio ablation or surgery is often c...

hrp0082p2-d2-602 | Thyroid (1) | ESPE2014

Influence of Amiodarone on Thyroid Function in Children

Nikitina Irina , Vasichkina Elena , Artemeva Irina , Liskina Anastasia , Lebedev Dmitri

Background: Unlike to adults, the side effects of long-term administration by amiodarone (A) of life-threatening arrhythmias (LThA) on thyroid function still is not studied exactly in children.Methods: Twenty-six children with LThA aged 1 week to 16 years (mean 10 years) treated by A were examined. The mean duration of oral treatment ranged from 1 month to 47 months (mean 12.5 months). We estimated serum level of T4, T3, TSH, antibo...

hrp0082p2-d2-603 | Thyroid (1) | ESPE2014

Euthyroid Sick Syndrome in Children with Diabetic Ketoacidosis

Hu Yanyan , Li Guimei , Wang Qian , Wang Zengmin , Wang Fengxue

Background: The correlation between free thyroid hormones and poor diabetic control in children with diabetic ketoacidosis (DKA) and the effects of thyroid hormone therapy on euthyroid sick syndrome (ESS) remain unclear.Objective and hypotheses: To investigate characteristics of ESS in children with DKA and the effects of thyroid hormone therapy on ESS. In children with DKA, free thyroid hormones may be associated with the severity of DKA and thyroid hor...

hrp0082p2-d2-604 | Thyroid (1) | ESPE2014

Levothyroxine Requirement in Congenital Hypothyroidism: 12-year Longitudinal Study

Vigone Maria Cristina , Lapolla Rosa , Delvecchio Maurizio , Salerno Mariacarolina , Wasniewska Malgorzata , Popolo Pietro Pio , Mussa Alessandro , Tronconi Giulia Maria , Di Mase Raffaella , D'Acunzo Ida , Falcone Rosa Maria , Corrias Andrea , De Luca Filippo , Weber Giovanna , Cavallo Luciano , Faienza Maria Felicia

Background: The replacement therapy with levo-thyroxine (LT4) in congenital hypothyroidism (CH) aims to ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence.Objective and hypotheses: i) To evaluate LT4/kg per day requirement from diagnosis until 12 years of age; ii) to assess any differences in relation to the different etiology of CH as concern...

hrp0082p2-d2-605 | Thyroid (1) | ESPE2014

Abstract withdrawn....

hrp0082p2-d2-606 | Thyroid (1) | ESPE2014

Genetic Studies in Congenital Hypothyroidism: a Regional Study

Hashemipour Mahin , Hopvsepian Silva

Background: Congenital hypothyroidism (CH) is considered as the most common endocrine disorder in neonates. CH may be caused by defects in the thyroid gland (dysgenesis) or in one of the stages in the synthesis of thyroid hormones (dyshormonogenesis). Early diagnosis and treatment of neonates with CH is crucial for their neurological development and preventing its related mental retardation. CH screening program have made the opportunity to achieve the mentioned goals. CH scre...

hrp0082p2-d2-607 | Thyroid (1) | ESPE2014

Premature Menarche Associated with Hashimoto Thyroiditis at 2 Years 9 Months: Case Report

Keskin Meliksah , Cetinkaya Semra , Sagsak Elif , Aycan Zehra , Erdeve Senay Savas

Background: Primary hypothyroidism is frequently associated with delayed puberty. However, precocious puberty is known to occur in some rare cases of hypothyroidism untreated for a long time. Differently from the cases suffering from precocious puberty due to other causes, linear growth and bone age are retarded in children developing precocious puberty associated with hypothyroidism. There are no definite data about the incidence of precocious puberty associated with hypothyr...

hrp0082p2-d2-608 | Thyroid (1) | ESPE2014

Iodine Nutrition and Neonatal Thyrotropin Levels in Lucknow, India

Bhatia Vijayalakshmi , Gopalakrishnan Vignesh , Joshi Kriti , Phadke Shubha , Dabadghao Preeti , Agarwal Meenal , Mootheden Cynthia , Das Vinita , Pandey Amita

Introduction: In India, newborn screening (NBS) for congenital hypothyroidism (CH) is not yet a national government policy. Preliminary information suggests neonatal TSH levels to be higher in expatriate Indian babies than those in European populations in developed countries.Objectives: To evaluate maternal urinary iodine and cord blood TSH in a subset of women participating in a postnatal NBS program for CH.Methods: Cord blood (CB...

hrp0082p2-d2-609 | Thyroid (1) | ESPE2014

Auxological Pattern, BMI and Endocrine Follow Up in Children with Congenital Hypothiroidism: the Data of the Pediatric Clinic of Palermo

Maggio Maria Cristina , Mineo Mariagrazia Irene , Maltese Marilena , Corsello Giovanni

Background: Congenital hypothyroidism (CH) has a high incidence, with a local increase in our screening relieves in the last years.Objective and hypotheses: An accurate follow up and an appropriate treatment guarantee an adequate neurological and auxological development.Method: We describe the personal report of 74 children (27 males and 43 females) with CH, diagnosed by neonatal screening and followed for 8.5±5.3 years.<p...