hrp0082p2-d2-331 | Diabetes (1) | ESPE2014

ACE Gene Insertion/Deletion Polymorphism and ACE Enzymatic Activity in Egyptian Children with Type 1 Diabetes with and without Microalbuminuria

Anwar Ghada , Bazaraa Hafez , Shaker Olfat , Arafa Noha , Hafez Mona , Mousa Noha

Background: Diabetic nephropathy is a major cause of morbidity and mortality among young adults with type 1 diabetes mellitus. Strong evidence exists in multiple studies for genetic predisposition of diabetic nephropathy. Genetic studies have revealed that the genes for the renin┬ľangiotensin system (RAS) are highly polymorphic, one of such is insertion/deletion polymorphism in ACE gene. This polymorphism was associated with the circulating ACE level and increased plasma a...