hrp0098p2-101 | Fat, Metabolism and Obesity | ESPE2024

Weight development and neuroendocrine deficits following proton beam therapy in children with craniopharyngioma

Bischoff Martin , Beckhaus Julia , Ahmad Khalil Dalia , Sabine Frisch , Koska Benjamin , Kiewert Cordula , Kortmann Rolf-Dieter , Bison Brigitte , Friedrich Carsten , L. Müller Hermann , Timmermann Beate

Background and aims: Craniopharyngiomas (CPs) are rare, non-malignant tumors near the pituitary and hypothalamus. Besides surgery, radiotherapy plays an important role in the treatment strategy. Both tumor-related factors and treatment can cause severe obesity and neuroendocrine disorders. Clinical studies have shown that endocrine deficits can occur at a dose level of 18Gy and risk increases with higher doses. Proton therapy (PT) is increasingly used in order...