hrp0092p1-363 | GH and IGFs (2) | ESPE2019
Damholt Birgitte B
, Bjelke Mads
, Helleberg Hans
, Rasmussen Michael H
Background: Somapacitan is a reversible albumin-binding growth hormone (GH) derivative developed for once-weekly administration in patients with GH deficiency (GHD). It consists of a human GH backbone, similar to endogenous human GH, with one amino acid substitution, attached to an albumin binder via a linker chain.Objective: Absorption, metabolism and excretion (AME) of somapacitan were investigated in a Phase 1 trial (...