hrp0086p2-p766 | Pituitary and Neuroendocrinology P2 | ESPE2016

Congenital Craniopharyngioma: Report of Two Cases

Bogusz Agnieszka , Moszczynska Elzbieta , Szalecki Mieczyslaw

Introduction: Craniopharyngiomas are slow growing epithelial tumors located in the sellar or suprasellar region of the brain. Adamantinomatous subtype affects mainly children and accounts for 5–10% of all intracranial paediatric tumors. Diagnosed antenatal and neonatal craniopharyngiomas are very seldom, about 40 such cases have been detected to date. They are characterised by large size, progressive hydrocephalus and a poor prognosis.Aim: The aim o...

hrp0086p1-p746 | Pituitary and Neuroendocrinology P1 | ESPE2016

Prognostic Significance of the Proliferative Index Ki67 for Patients with Craniopharyngiomas

Moszczynska Elzbieta , Bogusz Agnieszka , Szymanska Sylwia , Grajkowska Wieslawa , Szalecki Mieczyslaw

Background: Craniopharyngioma is a benign, slow-growing epithelial tumor, in children it contributes to 5–10% of all brain tumors. Its incidence is 0.5-2 per 1,000,000 person-years. 30–50% of these tumors are recognized in childhood, most often in ages 5–14, no sex predilection is observed. It is located mainly in the sellar/parasellar region, in children adamantinomatous variant, with tendency to recur, is the most common type. Views on the usefulness of immuno...

hrp0084p3-815 | Endocrine Oncology | ESPE2015

Craniopharyngioma – Symptoms, Treatment and Follow Up – An Analysis of 100 Cases

Moszczynska Elzbieta , Bogusz Agnieszka , Bendysz-Golatowska Anna , Szalecki Mieczyslaw

Background: Craniopharyngiomas are rare embryogenic malformations of the sellar area with low-grade histological malignancy. Its incidence is 0.5–2.0 cases per million persons per year, 30–50% of all cases become apparent in children.Objective and hypotheses: The aim of the study was to analyse the clinical symptoms and treatment efficacy in children diagnosed with Craniopharyngioma.Method: A retrospective analysis includ...

hrp0089fc10.4 | Late Breaking | ESPE2018

Hypothalamus Sparing Surgery Improves the Outcome of Patients with Severe Initial Hypothalamic Involvement of Childhood Craniopharyngioma: Results of the Prospective Multinational Trial KRANIOPHARYNGEOM 2007

Bogusz Agnieszka , Boekhoff Svenja , Warmuth-Metz Monika , Calaminus Gabriele , Eveslage Maria , Muller Hermann L

Context: Quality of survival (QoS) is frequently impaired in childhood-onset craniopharyngioma (CP) patients due to sequelae caused by the hypothalamic syndrome. The debate, whether primary hypothalamic involvement (HI) has apriori prognostic impact or surgical hypothalamic lesions (HL) determine outcome, is controversial. Accordingly, we analyzed, whether CP patients at high risk for hypothalamic obesity due to primary HI of anterior and posterior hypothalamic structures bene...

hrp0086p2-p765 | Pituitary and Neuroendocrinology P2 | ESPE2016

Symptomatic Rathke Cleft Cyst in Pediatric Patients – Clinical Presentations, Surgical Treatment and Postoperative Outcomes – An Analysis of 38 Cases

Prokop Monika , Moszczyńska Elżbieta , Bogusz Agnieszka , Daszkiewicz Paweł , Szalecki Mieczysław , Roszkowski Marcin

Background: Rathke cleft cysts are benign, epithelium-lined intrasellar and/or suprasellar cysts believed to originate from remnants of the Rathke pouch. Although its prevalence in adults is rather high, Rathke cleft cysts are rare in children. Often they are asymptomatic findings, however depending on their size and localization they can present with a wide spectrum of symptoms.Objective and hypotheses: The aim of the study was to analyse the symptoms a...