hrp0086fc10.5 | Perinatal Endocrinology | ESPE2016

Effects of Developmental Bisphenol A Exposure on Spermatozoal microRNA Expression

Fisher Benjamin , Sandovici Ionel , Braukmann Fabian , Frederiksen Hanne , Constancia Miguel , Miska Eric , Acerini Carlo

Background: Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, has been shown to exert transgenerational effects on adiposity, metabolism, and reproductive outcomes in rodents, indicating epigenetic inheritance. Recent studies of other environmental insults (stress and high-fat diet) have demonstrated a mechanistic role for spermatozoal microRNAs in the transgenerational transmission of acquired paternal traits.Objective and hypotheses: To as...