hrp0092p1-421 | Thyroid (2) | ESPE2019

Zinc Transporter 8 (ZnT8) as a New Autoantigen in Thyroid Tissue – Preliminary Data

Bossowski Artur , Niklinska Wieslawa , Gasowska Marta , Polnik Dariusz , Szalecki Mieczyslaw , Miklosz Agnieszka , Chabowski Adrian , Reszec Joanna

Zinc (Zn) is a crucial trace mineral that regulates the expression and activation of biological molecules such as transcription factors, enzymes, adapters, channels, and growth factors, along with their receptors. Bioinformatics analysis of the human genome discloses that Zn may bind ~ 10% of all of the proteins found in the human organism. This remarkable finding highlights the physiological significance of Zn in molecules involved in cellular processes and thereby i...

hrp0094p2-455 | Thyroid | ESPE2021

Expression of Zinc transporter 8 in thyroid tissues from patient with immune and non-immune thyroid diseases

Bossowski Artur , Niklinska Wiesława , Gasowska Marta , Polnik Dariusz , Szalecki Mieczysław , Mikłosz Agnieszka , Chabowski Adrian , Reszec Joanna

Introduction: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet autoantigen in type 1 diabetes.Materials and methods: We studied the expression of ZnT8 transporter in thyroid tissues from patients with im...