Previous issue | Volume 94 | ESPE2021

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

hrp0094p2-446 | Thyroid | ESPE2021

The efficacy and short- and long-term side effects of radioactive iodine treatment in pediatric Graves’ disease: a systematic review

Lutterman Sarah , Zwaveling-Soonawala Nitash , Verberne Hein , Verburg Frederik , van Trotsenburg Paul , Mooij Christiaan

Background: Graves’s disease (GD) is the most common cause of hyperthyroidism. Maximal 30% of pediatric GD patients achieve remission with anti-thyroid drugs. The majority of patients therefore require definitive treatment. Both thyroidectomy and radioactive iodine (RAI) are often used as definitive treatment for GD. However, data on efficacy, and short- and long-term side effects of RAI treatment for pediatric GD are relatively scarce.Methods: A ...

hrp0094p2-447 | Thyroid | ESPE2021

Incidentally detected papillary thyroid cancer with elevated calcitonin in a 15 year-old female: A case report

Yang Jaejin , Lee Wonae , Yu Jeesuk

Thyroid cancer in children is not common but there is a tendency to increase requiring early suspicion and close monitoring of thyroid nodule. Papillary thyroid cancer (PTC) is the most common type of thyroid cancer and medullary thyroid cancer (MTC) is rare, MTC can be suspected if there is elevated calcitonin level. A 15-year-6-month-old girl was admitted for generalized tonic seizure with fever. Initial Brain MRI showed a small oval diffusion restriction lesion in the midli...

hrp0094p2-448 | Thyroid | ESPE2021

Methimazole-induced remission rates in pediatric graves’ disease: A systematic review

van Lieshout Jelmer , Mooij Christiaan , van Trotsenburg Paul , Zwaveling-Soonawala Nitash

Objective: Comparison of studies on remission rates in pediatric Graves’ disease is complicated by lack of uniformity in treatment protocols, remission definition, and follow-up duration. We performed a systematic review on remission rates in pediatric Graves’ disease and attempted to create uniformity by recalculating remission rates based on an intention-to-treat analysis. Results: Of 1,890 articles, 29 articles consist...

hrp0094p2-449 | Thyroid | ESPE2021

Congenital multinodular goiter causing acute airway obstruction in a newborn: a case report

Mirjam Scheffer-Rath , Katharina Löhner , Nitash Zwaveling-Soonawala , Boot Annemieke

Introduction: Multinodular goiter is an extremely rare condition in neonates and can account for tracheal airway compression.Case report: A newborn girl presented immediately after birth with an inspiratory and expiratory stridor and a visible swelling in the neck. She was born term after an uneventful pregnancy with a birth weight of 3.26 kg. The mother had no known thyroid disease and had not used antithyroid or goitrogenic medication. She had a normal...

hrp0094p2-450 | Thyroid | ESPE2021

Initial response to thionamide medication in young people with newly diagnosed thyrotoxicosis

Wood Claire , Morrison Niamh , Cole Michael , Donaldson Malcolm , Dunger David , Wood Ruth , Pearce Simon , Cheetham Tim

Methods: Patients commenced 0.75mg/kg carbimazole (CBZ) daily with randomisation to either BR or DT. We examined baseline patient characteristics, CBZ dose, time to serum TSH/FT4 normalisation and BMI Z-score. Results: There were data available from 80 patients (baseline) and 78 patients (61 female) at 6 months. Mean CBZ dose was 0.9 mg/kg/day (BR) and 0.5 mg/kg/day (DT). There was no difference in the time taken for...

hrp0094p2-451 | Thyroid | ESPE2021

A girl with Trisomy 21 presents with Van Wyk-Grumbach syndrome. A rare diagnosis

Dikaiakou Eirini , Vlachopapadopoulou Elpis Athina , Kosteria Ioanna , Panos Alexandros , Dede Eirini , Koutrouveli Eleni , Zouridaki Christina , Michalacos Stefanos

Background: Van Wyk-Grumbach syndrome (VWGS) is a rare diagnosis that should be suspected in children with signs of peripheral precocious puberty and hypothyroidism. It is characterized by multicystic enlarged ovaries, in the presence of long-term severe hypothyroidism. Treatment of VWGS consists of hormonal replacement with levothyroxine. Usually, ovarian cysts and increased ovarian volume subside within an average of 2 months but can persist up to 12 months after treatment.<...

hrp0094p2-452 | Thyroid | ESPE2021

Complications after pediatric thyroidectomy: lymph node dissection is a risk factor for permanent hypocalcemia

van Rooijen Jesse J. , Paul van Trotsenburg A.S. , Zwaveling-Soonawala Nitash , Nieveen van Dijkum Els J.M. , Engelsman Anton F. , Derikx Joep P.M. , Mooij Christiaan F.

Background: Thyroidectomy is a definitive treatment option in some benign thyroid disorders and the definitive treatment option for thyroid cancer. As postoperative mortality is extremely rare data on postoperative complications and long-term health consequences are important.Objective: To evaluate the frequencies of short- and long-term complications, and their risk factors in pediatric patients (0-18 years) who underwent a thyroidectomy in a tertiary c...

hrp0094p2-453 | Thyroid | ESPE2021

Kinetics of FT4 serum concentrations in newborns and infants with congenital hypothyroidism during follow-up differ in the three severity groups

Steffens Britta , Gächter Pascal , Koch Gilbert , l'Allemand Dagmar , Janner Marco , Konrad Daniel , Welzel Tatjana , Pfister Marc , Szinnai Gabor

Background: The goal of congenital hypothyroidism (CH) treatment is rapid normalization and maintenance of TSH and FT4 in the reference range. Recommended starting dose of levothyroxine (LT4) ranges from 10-15 mg/kg/d. Hyperthyroxinemia can be accepted in the context of normal TSH and LT4 should only be reduced in case of symptoms or repeatedly increased FT4. The aim of this study was to quantify duration and maximum peak of FT4 levels outside the reference range for each CH s...

hrp0094p2-454 | Thyroid | ESPE2021

Thyroid dysfunction in small for gestational age infants: a need for second screening?

Park So Yun , Kang Seokjin

Recently there has been studies which reported that SGA could be a risk factor for the development of delayed TSH elevation (dTSH) in preterm infant. To our knowledge, very few studies have addressed development of dTSH in SGA infants whose gestational age > 34. We included 76 SGA infants and 83 controls matched on sex and birth weight who showed normal results on the initial thyroid function screening test. On the following test for thyroid function, dTSH prevalence was ...

hrp0094p2-455 | Thyroid | ESPE2021

Expression of Zinc transporter 8 in thyroid tissues from patient with immune and non-immune thyroid diseases

Bossowski Artur , Niklinska Wiesława , Gasowska Marta , Polnik Dariusz , Szalecki Mieczysław , Mikłosz Agnieszka , Chabowski Adrian , Reszec Joanna

Introduction: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet autoantigen in type 1 diabetes.Materials and methods: We studied the expression of ZnT8 transporter in thyroid tissues from patients with im...

hrp0094p2-456 | Thyroid | ESPE2021

Hashimoto Thyroiditis: long term follow-up from childhood to young adulthood

David Francesco , Casula Letizia , Guzzetti Chiara , Ibba Anastasia , Loche Sandro

Introduction: The evolution of Hashimoto Thyroiditis (HT) has been investigated by several studies both in pediatric and adult age. However, there are limited data on the progression of the disease from childhood to adulthood.Objective: Aim of the study was to describe the evolution of thyroid function in children with HT from childhood to young adulthood.Patients and Methods: The diagnosis of HT was defined by the presence of anti...

hrp0094p2-457 | Thyroid | ESPE2021

A case of complete atrioventricular block after initiation of methimazole in a patient with Graves' disease associated with Down's syndrome previously undergoing cardiac surgery

Sawano Kentaro , Hiroshima Shota , Shibata Nao , Nyuzuki Hiromi , Ogawa Yohei , Nagasaki Keisuke

Background&: Arrhythmias associated with hyperthyroidism are mainly tachyarrhythmias, such as sinus tachycardia and atrial fibrillation. In comparison, hypothyroidism shows several electrocardiographic changes, including sinus bradycardia, low amplitude QRS complexes, QT interval prolongation. There are few reports of bradyarrhythmia with hyperthyroidism, and it remains unclear.Case: The patient is a 13-year-old girl with Down's syndrome. She underw...

hrp0094p2-458 | Thyroid | ESPE2021

Unilateral autoimmune ophthalmopathy as a first symptom in manifestation of autoimmune thyroiditis and systemic lupus erythematosus in an adolescent girl. Case report.

Tolstikova Olena

A seventeen-year-old girl came to outpatient clinic complaining of enlargement and pains in the right eye. She had a history of a mild weight loss, anxiety and blurred vision for the last few weeks. She was referred from another clinic for evaluation of suspected hyperthyroidism. There was no family history of toxic goiter or exophthalmos. Her grandmother had a papillary thyroid cancer. On physical examination, the patient showed a significant increase in size in the right eye...

hrp0094p2-459 | Thyroid | ESPE2021

Incidence and etiology of primary congenital hypothyroidism in Flanders

Ryckx Sofie , De Mey Lynn , Marcelis Lionel , Vanbesien Jesse , Gies Inge , Staels Willem , Regal Luc , De Schepper Jean

Background and aims. In several European countries, the incidence of primary congenital hypothyroidism (PCH) seems to increase in the last decade, especially in countries that have lowered the newborn screening TSH cutoff. In Flanders, two centers manage since 2012 the newborn screening for PCH and these maintained the same TSH assay (Delphia, Perkin Elmer) and cutoff (15 mU/l). We studied the current incidence and etiology of PCH and initiation of thyroxine treatment in Fland...

hrp0094p2-460 | Thyroid | ESPE2021

Re-evaluation of the prevalence of permanent congenital hypothyroidism in Niigata, Japan: A retrospective study

Nagasaki Keisuke , Nyuzuki Hiromi , Shibata Nao , Sawano Kentaro , Hiroshima Shota , Ogawa Yohei

Introduction: Although newborn screening (NBS) for congenital hypothyroidism (CH) in Japan started more than 40 years ago, the prevalence of CH remains unclear. Prevalence estimations among the NBS-positive CH individuals include those with transient hypothyroidism and transient hyperthyrotropinemia, and re-evaluation with increasing age is necessary to clarify the actual incidence. Thus, we re-evaluated the incidence of permanent CH.Subjects and Methods...

hrp0094p2-461 | Thyroid | ESPE2021

Early reassessment in congenital hypothyroidism

Grau Gema , Bertholt María Laura , Chueca María , Artola Elena , Fernández María Concepción , Sarasua Ainhoa , Rodríguez Amaia , Vela Amaia , Berrade Sara , Naranjo Cristina , Puges Laura , Diez Ignacio , Espada Mercedes , Ascunce Nieves , Porras Begoña , Rica Itxaso

Introduction: 2020 ESPE guidelines recommend early reevaluation in primary congenital hypothyroidism (PCH) with thyroid in situ (TIS) and with levothyroxine dose lower than 3 mg/kg/day.Materials and Methods: Our Congenital Hypothyroidism screening program determine TSH and TT4 in dried blood spot (DBS) at 48 hours of life. A second DBS (DBS2) is indicated when the first is positive. Multicenter retrospective study (05/2016-05/2020; 105...

hrp0094p2-462 | Thyroid | ESPE2021

Growth impairment in children with severe autoimmune primary hypothyroidism and pituitary hyperplasia without goiter

Corica Domenico , Kucharska Anna Malgorzata , Vierucci Francesco , Valenzise Mariella , Li Pomi Alessandra , Tuli Gerdi , Munarin Jessica , Pyrzak Beata , Cesaretti Graziano , Aversa Tommaso , Wasniewska Malgorzata

Background: Prolonged severe hypothyroidism due to Hashimoto’s thyroiditis (HT) is a rare cause of pituitary hyperplasia (PH) in children. Loss of thyroxine negative feedback causes a TRH-dependent hyperplasia of pituitary thyrotroph cells resulting in adenohypophysis enlargement. A transdifferentiation of pituitary somatotroph cells into thyrotroph cells could explain growth failure in those patients. We report a case series of patients with growth impairment diagnosed...

hrp0094p2-463 | Thyroid | ESPE2021

The use of intravenous introduction of glucocorticoids in the active stage of graves’ ophthalmopathy in childhood. Clinical Case

Ivannikova Tatiana , Nagaeva Elena , Bezlepkina Olga

Clinical case: A 17-year-old patient was observed with a diagnosis of GD in October 2016. When the patient was examined in the hormonal profile there were hyperthyroidism, a high titer of antibodies to the TSH receptor, in connection of which thyrostatic therapy initiated. In dynamics since November 2018 there has been a pronounced increase in the total volume of the thyroid gland. Firstly she was examined at the Endocrinology Research Center in October 2019...

hrp0094p2-464 | Thyroid | ESPE2021

Atypical presentation of acute suppurative thyroiditis in a 6 year old child.

Liapi Maria , Möllers Martin , Feldkamp Joachim , Jorch Norbert

Bacterial infection of the thyroid gland (acute suppurative thyroiditis, AST) is a very rare condition, particularly in children, as the thyroid gland is extremely resistant to infection. AST presents with painful tender mass in the anterior neck and is usually associated with fever, sore throat, dysphagia and limitation of the neck movements. In the most cases the left globe is affected. Common laboratory findings are leukocytosis, elevated erythrocyte sedimentation rate (ESR...

hrp0094p2-465 | Thyroid | ESPE2021

Allan-Herndon-Dudley syndrome: case report of a rare disorder

Navasardyan Lusine , Muradyan Irina

Introduction: Allan-Herndon-Dudley syndrome (AHDS) is an X linked disorder – mutation of monocarboxylate transporter 8 (MCT8) gene. It leads to a severe psychomotor retardation, significant hypotonia of the skeletal muscles, spastic or dystonic quadriplegia. MCT-8 is responsible for the uptake of T3 by neurons of CNS. AHDS is characterized by increased T3 concentration, increased T3 / T4 ratio, TSH not depressed, even slightly elevated levels. Because of impossibility f...

hrp0094p2-468 | Thyroid | ESPE2021

Thyroid function in preterm infants admitted to the neonatal intensive care unit: a single center study

Nicolas Georges , Achkar Joy , Akiki Simon

Background: A common cause of neurodevelopmental impairment in children is congenital hypothyroidism, but can be preventable with adequate screening and proper management. Preterm newborns are more likely to have thyroid dysfunction, with small for gestational age (SGA) being an additional risk factor. However, only few studies addressed the altered thyroid hormone concentrations in the first few weeks of life concluding that Thyroid-Stimulating Hormone (TSH) levels are higher...

hrp0094p2-469 | Thyroid | ESPE2021

Thyroid dysfunction in Beta-thalassemia patients

Mustapha Noumi , Ladj MS , Rachid Terrak , Aissat L , Boukari R

Introduction: Β-thalassemia is a hereditary chronic hemolytic anemia characterized by a defect in the synthesis of beta-globin chains, particularly common in the Mediterranean region, southern Asia, and the Middle East Transfusion programs and chelation therapy have greatly extended the life expectancy of patients. This has led to an increase in the prevalence of endocrine complications, linked to iron overload The hypothyroidism is one of the most commonly reported comp...

hrp0094p2-470 | Thyroid | ESPE2021

Victim pathologies of the pandemic. Severe acquired hypothyroidism

Diez-Lopez Ignacio , Mesonerp Sara , Madera Maria , Sarasua-Miranda Ainhoa

Introduction: In the last year, the pediatric services have seen a reduction of up to 50% of the consultations and 1/3 of the admissions to the hospitalization ward; However, the existence of other pathologies cannot be forgotten despite the current situation, such as hypothyroidism, diabetic ketoacidosis, short stature, precocious puberty, etc., as far as endocrinology is concerned. Difficulty in accessing primary care, non-contact visits, along with the fear of families to g...

hrp0094p2-471 | Thyroid | ESPE2021

Mitigating thyroid cancer risk in multinodular hyperplasia secondary to a 10q23.31 deletion (PTEN Hamartoma Tumour Syndrome)

Shaunak Meera , Davies Justin

Introduction: The phosphatase and tensin homolog (PTEN) hamartoma tumour syndrome (PHTS) groups related multi-system genetic disorders linked to germline mutations in the PTEN gene. There is an increased risk of thyroid cancer in PHTS, with some cases arising in childhood. Annual surveillance for thyroid cancer by ultrasound is recommended.Case report: A 15 year old female was referred to Paediatric Endocrinology by Clinical Genetics fo...

hrp0094p2-472 | Thyroid | ESPE2021

Thyroid dysfunction and autoimmune thyroiditis in children with new-onset diabetes mellitus

Kim Goo Lyeon , Chun Sangwoo , Yu Jeesuk

Introduction: Type 1 diabetes mellitus (DM) can be related with other autoimmune disorders. Thyroid dysfunction and autoimmune thyroiditis are frequently reported in DM. This study was performed to evaluate the prevalence and risk factors of thyroid dysfunction and autoimmune thyroiditis in children with new-onset DM.Subjects and Methods: Children with DM and followed for more than 6 months in a single tertiary center were included in the study. Medical ...

hrp0094p2-473 | Thyroid | ESPE2021

A rare cause of congenital hypothyroidism: Brain-lung-thyroid syndrome

Yilmaz Aslihan Arasli , Erdeve Senay Savas , Yuksel Deniz , Oztoprak Ulkuhan , Cetinkaya Semra

Introduction: Brain-lung-thyroid syndrome (BATS) is a rare autosomal dominant inherited syndrome that develops due to mutations in the NKX2-1 gene, which is a thyroid transcription factor, and is characterized by respiratory distress in the neonatal period, congenital hypothyroidism, and choreatetosis. Approximately half of affected patients have the complete triad, with 30% affected by the neurological phenotype (motor developmental delay, gait difficulties, choreatetosis, hy...

hrp0094p2-474 | Thyroid | ESPE2021

Recurrent fractures in a child with Graves' disease

Kilci Fatih , Jones Jeremy , Çizmecioğlu Jones Filiz Mine

Introduction: Graves' disease is the most common paediatric cause of hyperthyroidism. Although hyperthyroidism has been reported to cause a decrease in bone mineral density (BMD), its association with recurrent bone fractures is extremely rare.Case: A 10-year-old male patient, who had a pre-existing 7-year diagnosis of autism spectrum disorder, presented to emergency with right leg pain that started after collision with an armchair. On initial exami...

hrp0094p2-475 | Thyroid | ESPE2021

Case study of 13- year-old boy suffering from papillary thyroid cancer in stage pT3aN1bMX

Bossowski Artur , Borysewicz-Sanczyk Hanna , Stożek Karolina , Dzięcioł Janusz , Czarniecka Agnieszka , Handkiewicz-Junak Daria , Jarząb Barbara

Papillary cancer represents majority of thyroid malignancies in children. However prognosis remains very successful. In recent years, we use elastography, except biopsy and standard ultrasonography in thyroid lesions diagnostic. We present a case of a male patient at the age of 13 years, with a history of ADHD and school phobia who was referred to Endocrinology Outpatient Clinic due to partial empty sella syndrome. Family history of endocrinological disorders was negative. Ph...

hrp0094p2-476 | Thyroid | ESPE2021

Evaluation of general characteristics of children with hypothyroidism

Bulut Eman , Eklioglu Beray Selver , Atabek Mehmet Emre

Aim: This study aimed to investigate retrospectively the demographic, clinical and laboratory data of patients followed up for hypothyroidism and to determine the insidance of persistent hypothyroidism.Materials and Methods: A total of 209 patients with hypothyroidism were included retrospectively in this study. Demographic data, clinical features, laboratory results, thyroid volume, follow-up time, treatment drug were recorded. These patients were divid...

hrp0094p2-477 | Thyroid | ESPE2021

L-T4 absorption test in 14-year-old patient with severe refractory hypothyroidism after total thyroidectomy

Vincenzi Gaia , Di Stefano Marina , Abbate Marco , Tarantola Giulia , Barera Graziano , Vigone Maria Cristina

Hypothyroid patients post-thyroidectomy require 1.6-1.8 mg/kg/die of Levothyroxine (L-T4). A persistent TSH level above the upper limit despite a daily dose >1.9 mg/kg/die is defined as “refractory” hypothyroidism in adults. Malabsorption and “pseudo-malabsorption” need to be investigated in case of therapeutic failure. L-T4 absorption test (LT4AT) is useful in distinguishing these two conditions but it has only been described in adult age. We ...

hrp0094p2-478 | Thyroid | ESPE2021

A child with anti-thyroid arthritis syndrome

Kilci Fatih , Sönmez Hafize Emine , Jones Jeremy , Közler Selen Hürmüzlü , Çizmecioğlu Jones Filiz Mine

Introduction: Anti-thyroid arthritis syndrome (AAS) is a rare complication that may occur in patients treated with anti-thyroid drugs. Presentation is variable and may include myalgia, arthralgia, skin rash, high fever, and polyarthritis. Herein, we present a girl diagnosed with AAS. Case report: A 9-year-old girl was admitted to emergency complaining of fever and arthralgia. She was the second child of non-consanguineous healthy parents. She had been d...

hrp0094p2-479 | Thyroid | ESPE2021

Thyroglobulin deficiency: a rare cause of neonatal stridor

Tseretopoulou Xanthippi , Reddy Nithya , Pinnamaneni RagaMallika , Jonas Nicolaas , Schoenmakers Nadia , Walton-Betancourth Sandra

Background: Nonimmune neonatal goitrous hypothyroidism is a rare cause of neck mass and stridor. Retropharyngeal extension, described in 7% of cases of goitre spreading outside the thyroid bed, represents a diagnostic dilemma that requires a systematic multimodality imaging approach combined with hormonal and genetic analysis. We report the case of a one-week-old baby who presented with stridor and respiratory distress, without palpable neonatal goitre and whose biochemical pr...

hrp0094p2-480 | Thyroid | ESPE2021

TBG deficiency and Central Congenital Hypothyroidism (CCH): Our experience in neonatal screening with TSH and T4

Chueca Maria J. , Grau Gema , Bertholt Laura , Artola Elena , Fernández Concepción , Sarasua Ainhoa , Rodriguez Amaia , Vela Amaia , Belza Amaia , Berrade Sara , Dura Teodoro , Alonso Pablo , Puges Laura , Diez Ignacio , Espada Mercedes , Ederra Maria , Ascunce Nieves , Porras Begoña , Rica Itxaso

Objective: Analyze CCH detection program results from 3 Autonomous Communities: TSH and total T4 (TT4) in dried blood spot (DBS) at initial screening (48 hours of life) and at retesting. Describe the characteristics of neonates with screening compatible with CCH. Consider whether TBG deficiency (TBGD) is an added difficulty in said study.Materials and Methods: Retrospective study (May 2016-May 2020) of all neonates ≥33 weeks and/or ≥1500 gr...

hrp0094p2-481 | Thyroid | ESPE2021

A case of hypothyroidism post bone marrow transplantation

Baz Ouidad , Chelghoum Imane Lydia , Mimouni Safia

Introduction: Changes in thyroid function and thyroid function tests occur in patients with β-thalassemia major (TM). The frequency of hypothyroidism in TM patients ranges from 4% to 29 % in different reports. Bone marrow transplantation (BMT) is based on destruction of the patient’s bone marrow with rescue of haematopoietic stem cells from a donor. Chronic graft-vs-host disease (GVH) is the major complication post-BMT and mimics some autoimmune diseases, such as ...

hrp0094p2-482 | Thyroid | ESPE2021

Iodine status and autoimmune thyroiditis in children; a case-control study in Sri Lanka

Hashim Raihana , Mahesh Buddika , Atapattu Navoda , de Silva Shamya

Conclusions: Iodine nutrition status in children in both groups was optimal, based on urinary iodine concentration. Furthermore, there was no significant association between iodine intake and autoimmune thyroiditis....

hrp0094p2-483 | Thyroid | ESPE2021

A 9-year-old girl with Van Wyk and Grumbach syndrome: precocious puberty as a rare consequence of hypothyroidism

Osokina Irina

Background: The syndrome consisting of primary hypothyroidism, precocious puberty, and massive ovarian cysts was termed Van Wyk and Grumbach syndrome (VWGS) in 1960. Chronic lymphocytic thyroiditis is the more common cause of hypothyroidism in children. In patients with severe longstanding hypothyroidism, the sella turcica may be enlarged due to thyrotrope hyperplasia. Puberty tends to be delayed in hypothyroid children in proportion to the retardation in the bone age, althoug...

hrp0094p2-484 | Thyroid | ESPE2021

Iodine Deficiency Cretinism in Tuva Republic

Osokina Irina

Introduction: Iodine deficiency is the most common cause of mental retardation that can be prevented. The most serious consequence of iodine deficiency is cretinism. The Republic of Tuva is one of 89 administrative territories of the Russian Federation. Tuva lies in the south of Siberia and bordering Mongolia. In 1997 we first discovered the pocket of severe iodine deficiency in the Republic of Tuva and found cases of endemic cretinism. The aim: To study the features of iodine...

hrp0094p2-485 | Thyroid | ESPE2021

Prevalence and associated factors of Congenital Hypothyroidism in Bogotá, Colombia. 2014 - 2020

Pineda Pablo , Beltrán Daniela , Salazar Alexander , Sarmiento Karen , Zarante Ignacio , Urueña Ana

Results: During the years of this study, the prevalence of NB reported as suspected with CH was 1:1220 NB, showing a stable trend on the linear tendency analysis; when adjusted for cases with confirmed high values of TSH in umbilical cord measurement, the prevalence is 1:3041 NB. Regarding the demographic data of the patients analyzed, it was found 54% were men and 46% women. Of the total CH cases with a reported weight, 20% weighted less ...

hrp0094p2-486 | Thyroid | ESPE2021

Aetiology and different clinical condition of hypothyroidism in children and adolescents

Bouferoua Fadila

Objective: To evaluate clinical features, etiology and evolution of patients with hypothyroidism.Methods: Longitudinal retrospective study of patients diagnosed with hypothyroidism between 2004 and 2019. Study was conducted in the west of Algiers. Age at diagnosis, clinical characteristics and initial dose of treatment were recorded. Patients were classified according to etiology. In congenital hypothyroidism, neurocognitive assessment...

hrp0094p2-487 | Thyroid | ESPE2021

Influenza A induced Thyrotoxic Storm Post Haematopoietic Stem Cell Transplantation

Bhayankaram Nuthana Prathivadi , Murray Philip

Background: Thyroid storm is a rare occurrence of severe thyrotoxicosis, most commonly associated with Grave’s disease and is reported to have a high morbidity and mortality. It is particularly rare in children. Whilst there is a scoring system to diagnose thyroid storm in adults, there is not an equivalent for children. Here, we describe the case of a patient who developed thyroid storm secondary to influenza A infection.Case Report: A 13-year-o...

hrp0094p2-488 | Thyroid | ESPE2021

The state of iodine deficiency in Krasnoyarsk territory according to results of neonatal TSH screening in 2019

Osokina Irina

Background: Iodine deficiency is associated with goiter and impaired brain function. Neonatal thyroid-stimulating hormone (TSH) screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency. In the absence of iodine deficiency, the frequency of neonatal TSH above 5 mU/L whole blood is less than 3%. A frequency of 3%-19.9% indicates mild IDD. Frequencies of 20%-39.9% indicate moderate and above 40% severe IDD.The aim: to ...

hrp0094p2-489 | Thyroid | ESPE2021

Thyrotropic cell hyperplasia secondary to prolonged uncontrolled primary hypothyroidism

Ariza Jimenez Ana Belen , Ariza Jimenez Jose Antonio , Vargas Elena Lopez

Introduction: Prolonged evolution of an untreated hypothyroidism can lead to thyrotropic cell hyperplasia, which could be indistinguishable from a pituitary macroadnoma on resonance. Differential diagnosis is very important since it allows to avoid aggressive therapeutic behaviors.Case report: We show a 3-year-old girl who, in the context of a study due to psychomotor retardation, borderline head circumference and coarse features, presented in magnetic r...

hrp0094p2-490 | Thyroid | ESPE2021

Thyroid dyshormonogenesis: a case report of two siblings with a heterozygous variant in the TPO gene.

Vadina Tatiana , Konushova Marina , Eremyan Aikaz , Shreder Ekaterina , Nagaeva Elena , Zaharova Svetlana , Degtyarev Michael , Bezlepkina Olga

Background: Congenital hypothyroidism (CH) is an inborn disease with an incidence rate of 1 case per 3,600 newborns of which 15-20% cases are associated with thyroid dyshormonogenesis. The TPO gene encodes thyroid peroxidase. Disease associated with this gene is usually transmitted in an autosomal recessive mode. Hypothyroidism-associated TPO variants are usually biallelic, limited evidence for cases in patients with heterozygous variants exists.Method...

hrp0094p2-491 | Thyroid | ESPE2021

Pediatric Graves’ disease in southern Tunisia

Kmiha Sana , Zghal Mohammed Ali , Chabchoub Imen , Ameur Salma Ben , Aloulou Hajer , Kammoun Thouraya

Background: Hyperthyroidism is uncommon in children. Graves’ disease is the most common cause in pediatric population. The diagnosis is based on the presence of anti-TSH receptor antibodies. Pediatric Graves’ disease has some peculiarities mainly in term of treatment and evolution, since its prognostic is different than adults.Aim: The aim of this study is to describe the epidemiological, clinical and biological features of pediatric Graves...