ESPE Abstracts

Aim: This study aimed to investigate retrospectively the demographic, clinical and laboratory data of patients followed up for hypothyroidism and to determine the insidance of persistent hypothyroidism.

Materials and Methods: A total of 209 patients with hypothyroidism were included retrospectively in this study. Demographic data, clinical features, laboratory results, thyroid volume, follow-up time, treatment drug were recorded. These patients were divided into three groups (subclinical hypothyroidism, transient and permanent hypothyroidism).

Results: Forty four% (94) of the patients were female and 55% (115) were male. The anatomical structure of the thyroid gland varied between hypoplasia, agenesis and normal structure and they were 1%, 8,1% and 90,9% respectively. The patients with the transient, the permanent and subclinic hypothyroidism were 29,7%, 58,9%, 11,5% respectively. On the day of admission of the patients median was 21 days . The median duration of treatment was 40 months .The mean body weight SDs was -0,69, the mean height was 57,8 ± 11,08 and body weight compaired to the height was 113,5 , and the birth weight was 2933 g.Both transient and permanent TSH levels were higher than those of subclinical patients and this difference was statistically significant (P <0.05).Thyroid volume was higher in patients with transient hypothyroidism than those with permanent hypothyroidism, which was statistically significant (P <0.05). There were no statistically significant difference in TSH level in patients with transient and permanent hypothyroidism (p> 0.05). There were no statistically significant difference in sex, delivery method, birth week and birth weight according to the type of hypothyroidism (P> 0.05). Thyroglobulin levels of the transient, the permanent and the subclinical hypothyroidism were found cut-off 104, 34, 40.6, sensitivity 55.77%, 72.12%, 70%, specificity 100%, 84.21%, 75% respectively. TSH levels of the transient, the permanent and the subclinical hypothyroidism were found cut-off 10.3, 10.5, 10 sensitivity 100%, 100%, 100%, specificity 88.4%, 75.96%, 25% respectively. ST4 level of the transient, the permanent, the subclinical hypothyroidism were found cut-off 0.92, 0.93, 0.90 sensitivity 100%, 100%, 100%, specificity 100%, 100%, 100% respectively.

Conclusion: Determining the etiology and type of hypothyroidism plays an important role in the treatment and follow-up of patients. Hypothyroidism should be considered in every patient with growth retardation and mental retardation. When hypothyroidism is noticed in the early period, we believe that it is necessary to remain under close follow up and monotoringr because the problems caused by hypothyroidism can be treated.