ESPE Abstracts

Background: Iodine deficiency is associated with goiter and impaired brain function. Neonatal thyroid-stimulating hormone (TSH) screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency. In the absence of iodine deficiency, the frequency of neonatal TSH above 5 mU/L whole blood is less than 3%. A frequency of 3%-19.9% indicates mild IDD. Frequencies of 20%-39.9% indicate moderate and above 40% severe IDD.

The aim: to estimate the iodine deficiency in Krasnoyarsk territory according the results of neonatal TSH screening in 2019.

Methods: An analysis of neonatal TSH screening was performed in 14,560 newborns participating in the national thyroid newborn screening program in 2019. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 96 hours after birth, using DELFIA method.

Results: According to the data of the congenital hypothyroidism screening the rate of TSH < 5 mU/1 was 9.4% in Krasnoyarsk territory (11.8% was in 2015; 23.9% in 2000) and corresponded to mild iodine deficiency. In different regions of Krasnoyarsk territory the rate of neonatal TSH < 5 mU/1 varied from 1.4% in central Novoselovskiy district to 36.5% in northern Evenkiyskiy region. The state of iodine deficiency in Arctic Taimyrskiy region was better in 2019: the frequency of TSH < 5 mU/1 was 16.5% (23.7% in 2015; 29.9% in 2000), but corresponded to moderate iodine deficiency. In Krasnoyarsk city the rate of TSH < 5 mU/1 was 7.7% in 2019 (9.2% in 2015, 23.5% in 2000). These results indicate mild iodine deficiency.

Conclusion: Analysis of the neonatal TSH screening show mild iodine deficiency in central part of Krasnoyarsk territory. In Arctic Taimyrskiy and northern Evenkiyskiy regions saved moderate iodine deficiency. This demand continuous adequate iodine prophylaxis to prevent cognitive outcomes.

References:

1. Delange F.Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. Thyroid. 1998. V. 8:1185-1192.

2. Osokina I.V., Manchouk V.T. Iodine deficiency disorders in Siberia. Novosibirsk, Science. 2012: 1–153.

3. Osokina I.V. Iodine Deficiency in Central Siberia. Exploring, prevention and monitoring. Palmarium academic publishing, Germany. 2013: 1–234.

4. Osokina I.V. Neonatal thyroid-stimulating hormone screening as an indirect method for the assessment of iodine status in Central Siberia. International Journal of Diabetes and Metabolic Disorders. 2018. V 3. № 4: 1-3.

5. Osokina I. Iodine Deficiency in Central Siberia, Russia. Acta Scientific Nutritional Health. 2019. V 3, N 10, P. 127-129.