hrp0092p3-103 | Fat, Metabolism and Obesity | ESPE2019

Relationship Between 25-Hydroxyvitamin D with Adiposity Assessed by Body Mass Index, Serum Glucose and Lipids Levels in Korea: A Cross-Sectional Analysis

Shim Kye Shik , Cho Ja Hyang , Jung Hae Woon

Purpose: Vitamin D deficiency is thought to be influenced by cardiovascular function and glucose homeostasis, however the potential influence of vitamin D status on insulin resistance, is not well understood. The aim is investigate the correlations between 25-hydroxyvitamin D[25(OH)D] with adiposity assessed by body mass index(BMI), fasting glucose and lipid levels on schoolchildren.Methods: From April 2015 to July 2018,...

hrp0086p1-p627 | Growth P1 | ESPE2016

Change of Growth Pattern and Thickness of Epiphyseal Plate in Female Rats According to Injected Estrogen Dosage

Kang ByungHo , Shim Kye Shik , Lim Sung Jig , Cho Ja Hyang

Objective and hypotheses: The purpose was to get the basic data of optimum serum concentration of estrogen in maximizing pubertal growth spurt, and decreasing the acceleration of epiphyseal closure of long bones.Method: i) Fifteen female SD rats (13-week aged; post pubertal growth spurt) were randomly divided into three groups. After 1 week, the group 1 were injected subcutaneously with sesame oil, as a control, group 2 were with 10 μg/kg per week o...

hrp0082p2-d1-520 | Pituitary | ESPE2014

Hypothalamic Obesity in Children with Craniopharyngioma: Prevalence and Risk Factors of Obesity and Longitudinal Trends of BMI

Cho Ja Hyang , Kim Ja Hye , Kim Yoo-Mi , Choi Jin-Ho , Yoo Han-Wook

Background: Craniopharyngioma is the most common parasellar tumor in childhood arising from remnants of Rathke’s pouch. As the hypothalamus plays a vital role in regulation of body weight by balancing energy intake and expenditure, hypothalamic damage by structural lesions is one of the most common causes of hypothalamic obesity. This study investigated prevalence, risk factors for the development of hypothalamic obesity, and consequent morbidities in children following t...

hrp0084p2-189 | Adrenals | ESPE2015

The Aetiological Spectrum of Congenital Adrenal Hyperplasia Based on Molecular Genetic Analyses

Choi Jin-Ho , Kim Ja Hye , Kang Eungu , Cho Ja Hyang , Kim Gu-Hwan , Yoo Han-Wook

Background: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by a defect in cortisol biosynthesis. The most common form of CAH is the 21-hydroxylase deficiency (21-OHD), however, the incidence and the etiologic spectrum of other forms of CAH were not reported.Objective and hypotheses: This study describes the etiological distribution and clinical characteristics of CAH in a single academic centre.<p class...

hrp0084p2-528 | Puberty | ESPE2015

Correlation of Clinical Phenotype and Genotype of Prader-Willi Syndrome and the Deletion of Paternal MKRN3 Allele in PWS Patients with Central Precocious Puberty

Cho Ja Hyang , Kang Eungu , Choi Jin-Ho , Kim Gu-Hwan , Seo Eul-Ju , Yoo Han-Wook

Background: Prader-Willi syndrome (PWS) is caused by the deletion of the paternally-derived 15q11-13 region or the maternal uniparental disomy of chromosome 15 (mUPD(15)). Puberty is usually delayed and central precocious puberty (CPP) is very rare in PWS.Objective and hypotheses: This study was undertaken to correlate clinical features focusing on pubertal progression with genotype with or without MKRN3 deletion to understand the mechanism of C...

hrp0084p3-644 | Bone | ESPE2015

Clinical and Molecular Characterisation of Patients with Pseudohypoparathyroidism

Kang Eungu , Kim Yoon-Myung , Cho Ja Hyang , Kim Gu-Hwan , Choi Jin-Ho , Yoo Han-Wook

Background: Pseudohypoparathyroidism (PHP) is a heterogeneous group of disorders characterized by hypocalcemia, hyperphosphataemia and Albright hereditary osteodystrophy (AHO), resulting from abnormalities of GNAS.Objective and hypotheses: This study investigated clinical features, outcomes, molecular characteristics of patients with PHP and pseudopseudohypoparathyroidism (PPHP).Method: Thirty one patients (15 males and 16...

hrp0084p3-765 | Diabetes | ESPE2015

A Case of DEND (Developmental Delay, Epilepsy, and Neonatal Diabetes) Syndrome with Heterozygous KCNJ11 Mutation Successfully Treated with Sulfonylurea Therapy

Kim Ja Hye , Cho Ja Hyang , Kang Eungu , Choi Jin-Ho , Kim Gu-Hwan , Yoo Han Wook

Background: Permanent neonatal diabetes mellitus is caused by mutations in the KATP channel subunits. DEND (Developmental delay, Epilepsy, and Neonatal Diabetes) syndrome is the most severe form of permanent neonatal diabetes. We experienced a patient with DEND syndrome, who was initially misdiagnosed as type 1 diabetes, who has been successfully switched from insulin injection to oral sulfonylurea therapy.Case presentation: A 50-day-old male ...