hrp0089fc12.6 | Diabetes and Insulin 2 | ESPE2018
Maftei Oana
, Couper Jennifer
, Anderson Jemma
, Ricci Peter
, Gent Roger
, Giles Lynne
, Pena Alexia
Puberty is a critical period for the development and acceleration of vascular complications in Type 1 diabetes (T1D). We have shown that metformin in addition to insulin improves vascular smooth muscle function and HbA1c in T1D children over 12 months (1). We aimed to determine if children with T1D who received metformin in a randomized controlled trial (RCT) [Trial registration ACTRN126110001148976] have a sustained vascular function improvement 3 years after ceasing metformi...