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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 1

Diabetes and Insulin (1)

hrp0092p1-178 | Diabetes and Insulin (1) | ESPE2019

The Efficacy and Safety of Predictive Low Glucose Suspend Feature in Decreasing Hypoglycemia in Children with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Alotaibi Ahlam , Alkhalifah Reem , McAssey Karen

Background: Hypoglycemia is a common side effect of insulin replacement therapy in patients with type 1 diabetes mellitus (T1DM). With the advancement of diabetes technology, sensor-augmented pump therapy (SAP) with predictive low glucose suspend feature offers a potential solution for hypoglycemia in patients with T1DM. However, evidence from randomized trials about the efficacy and safety of PLGS is limited.Method: We ...

hrp0092p1-179 | Diabetes and Insulin (1) | ESPE2019

Longitudinal Metabolic Control After Initiation of Insulin Pump in 5,040 Pediatric Type-1-Diabetes Subjects – Heterogeneous HbA1c Trajectories Over Three Years from the DPV Registry

Prinz Nicole , Schwandt Anke , Becker Marianne , Biester Torben , Hess Melanie , Holder Martin , Karges Beate , Näke Andrea , von Sengbusch Simone , Tauschmann Martin , Holl Reinhard W.

Objectives: Continuous subcutaneous insulin infusion (CSII) has been associated with lower HbA1c. To explore whether CSII initiation leads to HbA1c improvement in each individual with type-1 diabetes and to identify co-variates which might influence change in HbA1c.Methods: 5,040 pediatric type-1-diabetes subjects (δ20 y, 49% boys, median age at diabetes onset [Q1;Q3]: 5.9 [3.5;8.4] years) ...

hrp0092p1-180 | Diabetes and Insulin (1) | ESPE2019

Efficacy and Safety of Insulin Degludec as a Basal Insulin in Adolescents with Type 1 Diabetes During Ramadan Fasting: A Single Center Observational Study with Freestyle Libre Flash Glucose Monitoring System

Elbarbary Nancy

Background: Insulin degludec (IDeg) is an ultra-long-acting insulin, with flat time-action profile, having a lower risk of hypoglycemia. Many adolescents with type 1 diabetes, choose to observe Ramadan fasting for spiritual wellbeing despite different risks.Aim of study: To assess frequency, timing and severity of hypoglycemia of insulin IDeg as basal insulin in T1DM adolescence who are willing to fast. Other outcomes in...

hrp0092p1-181 | Diabetes and Insulin (1) | ESPE2019

A Case of Prohormone Convertase Deficiency Diagnosed with Type 2 Diabetes Mellitus

Kucukali Gulin Karacan , Savas-Erdeve Senay , Cetinkaya Semra , Keskin Meliksah , Bulus Ayse Derya , Aycan Zehra

Background: Prohormone convertase is an enzyme that converts many biologically inactive prohormones into biologically active peptides. Its deficiency is characterized by deficiency of variable levels in all the hormone systems. In relation to this, postprandial hypoglycemia has been reported but, a case of prohormone convertase deficiency presenting with a diagnosis Type 2 diabetes mellitus has not been previously reported.Case p...

hrp0092p1-182 | Diabetes and Insulin (1) | ESPE2019

The Influence of Excess Iron on Pancreatic Beta Cells

Zhang Lina , Hou Lele , Liu Zulin , Li Pinggan , Huang Siqi , Meng Zhe , Ou Hui , Jiang Zhuannan , Liang Liyang

Objective: To establish INS-1 cell iron overload model, and study the effect on iron overload, proliferation, insulin secretion, mitochondria defect and oxidative stress change.Methods: INS-1 cells were cultured with different concentrations (0 as control and 5, 10, 20, 40, 80,160,320µmol/L respectively) of ferric ammonium citrate (FAC). Labile iron pool (LIP) were calculated by detecting calcein-AM fluorescence ...

hrp0092p1-183 | Diabetes and Insulin (1) | ESPE2019

Study on the Mechanism of Metformin in Improving PGRN-Induced Insulin Resistance of 3T3-L1 Cell

Huang Siqi , Liang Liyang , Meng Zhe , Zhang Lina , Hou Lele , Liu Zulin , Chen Hongshan

To investigate the effect of metformin on the PERK-eIF2a pathway in PGRN - induced insulin - resistant cell model. METHODS: The 3T3-L1 Insulin-resistance cell model was constructed by dexamethasone and PGRN. Metformin was used to act on the cell model to screen out the optimal concentration group for reducing PGRN,The experiment was divided into the normal control group, dexamethasone group, and PGRN group. 4-PBA and metformin were used to act respectively.Western Blot was use...

hrp0092p1-184 | Diabetes and Insulin (1) | ESPE2019

A Case with Monogenic Diabetes Caused by RFX6 Mutation in a 14-Year-Old-Girl

Kim Goo Lyeon , Kwak Soo Heon , Yu Jeesuk

Introduction: In previous times, diabetes mellitus in children and adolescents was usually type 1 diabetes which was caused by autoimmune beta cell destruction, but due to the increased prevalence of obesity, the incidence of type 2 diabetes was explosively increased in children and adolescents. The underlying mechanism of childhood-onset type 2 diabetes mellitus may be different to the adult-onset type 2 diabetes. It is worthwhile to find new causes of monoge...

hrp0092p1-185 | Diabetes and Insulin (1) | ESPE2019

Endothelial and Heart Dysfunction in Children and Adolescents with Type 1 Diabetes

Predieri Barbara , Lami Francesca , Cenciarelli Valentina , Ciancia Silvia , Righi Beatrice , Madeo Simona F. , Bruzzi Patrizia , Prampolini Beatrice , Iughetti Lorenzo

Background/Objectives: Type 1 diabetes (T1D) is an important risk factor for cardiovascular disease (CVD). Even if CVD become mainly manifest in adulthood, the process of atherosclerosis starts in childhood. Ultrasound is a reliable and noninvasive method for detecting early structural and functional atherosclerotic changes in arterial wall and heart. Aim of this study was to determine early ultrasound signs of atherosclerosis and of left ventricular (LV) syst...

hrp0092p1-186 | Diabetes and Insulin (1) | ESPE2019

Efficacy of Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Childhood Type 1 Diabetes

Pei Zhou , Wang Hongsheng , Luo Feihong

Objective: To observe and analyze the efficacy and safety of autologous stem cell transplantation (AHSCT) in children with type 1 diabetes.Methods: Twelve children were enrolled in our study who were newly diagnosed as type 1 diabetes in Children's Hospital of Fudan University from Sep. 2009 to Dec. 2011. Changes in the exogenous insulin requirement were observed and HbA1C and C peptide level were measured before and...

hrp0092p1-187 | Diabetes and Insulin (1) | ESPE2019

Course of Puberty and Growth Spurt in Boys with Type 1 Diabetes

Shpitzer Hana , Lazar Liora , Shalitin Shlomit , Phillip Moshe , de Vries Liat

Background: Data on the course of puberty and pubertal growth in boys with Type 1 diabetes (T1D) are sparse.Objectives: To study the course of puberty, pubertal growth and final height in boys with T1D as well as possible factors affecting these.Methods: In this retrospective longitudinal study, 68 boys diagnosed with T1D between 1996-2009 who were pre-pubertal at diagnosis and had...

hrp0092p1-188 | Diabetes and Insulin (1) | ESPE2019

A Novel Mutation in the Pancreatic Duodenal Homeobox-1(PDX-1) Gene in a Palestinian Family Resulting in Neonatal Diabetes Associated with Congenital Adrenal Hyperplasia

Abu-Libdeh Abdulsalam , Abedrabbo Amal , Abu-Libdeh Bassam

Background: PDX-1 gene is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene cause pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM).Clinical Data: A 1-day-old male newborn, admitted to NICU due to antenatal diagnosis of duodenal atresia, polyhydramnios and IUGR. Laparotomy re...

hrp0092p1-189 | Diabetes and Insulin (1) | ESPE2019

A Novel SLC2A2 Mutation Implicated in Fanconi Bickel Syndrome and Dysglycemia

Sharari Sanaa , Aouida Mustapha , Khan Faiyaz , Al-Khawaga Sara , Mohammed Idris , Haris Basma , Saraswathi Saras , Mundekkadan Shihab , Hussain1 Khalid

Background: Fanconi Bickel syndrome (FBS) is a rare form of glycogen storage disease (GSD) inherited in an autosomal recessive manner and caused by mutations in the SLC2A2 gene leading to the loss of GLUT2 glucose transporter expression. The disease is considered to be rare in which a little more than 100 cases have been reported in the literature. The SLC2A2 gene encodes for GLUT2, a low affinity facilitative glucose transporter expressed in critical tissues ...

hrp0092p1-190 | Diabetes and Insulin (1) | ESPE2019

Periodontal Disease Relates to Diabetes Control in Children and Adolescents with Type 1 Diabetes

Ports Emilija , Pena Alexia , Allen Gabrielle , Gue Sam , Couper Jennifer

Background: Obese children with and without Type 2 diabetes have periodontal disease that relates to systemic inflammation. There is limited data on periodontal disease in children with Type 1 diabetes (T1D).Aim: We aimed to assess periodontal disease markers and its determinants in children and adolescents with T1D.Materials and Methods: Cross-sectional study including 73 children...