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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 1

Fat, Metabolism and Obesity (1)

hrp0092p1-191 | Fat, Metabolism and Obesity (1) | ESPE2019

Effect of Probiotics Intake on Obese Children

Chen Ruimin , Ai Zhuanzhuan , Yang Xiaohong , Zhang Ying , Yuan Xin

Background: Childhood obesity has been a worrisome public health issues today. Recent studies conducted in adult populations and animals have suggested beneficial effects of probiotics on obesity, while, the experience is limited in the pediatric age group and the results are conflict.Object: The primary objective was to determine the effect of Probiotics consumption on weight change. The secondary objective was to deter...

hrp0092p1-192 | Fat, Metabolism and Obesity (1) | ESPE2019

Changes in Objectively Measured Sleep Quality After an Integral Intervention in Patients with Abdominal Obesity

Azcona Cristina , Catalán Ana , Morell Lydia , Ojeda Ana , Chueca María , Marti Amelia

Aim: to study sleep quality, using accelerometry in children and adolescents with abdominal obesity after a multidisciplinary intervention.Patients, Material and Methods: we included 122 children and adolescents, range age: 7 to 16 years old, diagnosed with abdominal obesity (waist circumference > p90) who participated in an 8-week intervention program to lose weight, with a 2-year follow-up period. Participants were...

hrp0092p1-193 | Fat, Metabolism and Obesity (1) | ESPE2019

Circulating Insulin-Like Growth Factor-I Independently Predicts Blood Pressure in Apparently Healthy Children

Xargay-Torrent Sílvia , Dorado-Ceballos Estefanía , Benavides-Boixader Anna , Lizárraga-Mollinedo Esther , Mas-Parés Berta , Montesinos-Costa Mercè , Zegher Francis de , Ibáñez Lourdes , Bassols Judit , López-Bermejo Abel

Background and Objectives: In adults, discordant associations exist between insulin-like growth factor-I (IGF-I) and blood pressure with scarce reports in apparently healthy children. IGF-I levels increase during puberty in parallel to calcium and phosphorus levels. In this context, our aim is to study the association between IGF-I and blood pressure in apparently healthy children, together with the interaction of the serum calcium-phosphorus product (Ca*P...

hrp0092p1-194 | Fat, Metabolism and Obesity (1) | ESPE2019

Whole Exome Sequencing to Identify Causative Variants in a Female Patient with Early Onset Obesity and Intellectual Disability: A New Case of Borjeson-Forsman-Lehmann syndrome

Pagliazzi Angelica , Artuso Rosangela , Traficante Giovanna , Giunti Laura , Bosi Emanuele , Provenzano Aldesia , La Barbera Andrea , Guarducci Silvia , Palazzo Viviana , Pantaleo Marilena , Lucherini Barbara , Sani Ilaria , Formicola Daniela , Reho Paolo , Bargiacchi Sara , Dosa Laura , Peluso Francesca , Forzano Giulia , Contrò Gianluca , Di Giovanni Fabiana , Stagi Stefano , Giglio Sabrina

The epidemic spread of obesity in children has triggered the commitment of scientific research, which has allowed us to understand its genetic basis; the different forms of genetic obesity share common clinical aspects, making it difficult to achieve a molecular diagnosis based only on our clinical suspicion. We report a female patient presented with neonatal hypotonia, hyperphagia and early onset excessive weight gain, strabismus and high hypermetropia. Regarding her neurodev...

hrp0092p1-195 | Fat, Metabolism and Obesity (1) | ESPE2019

Serum Leptin, Adiponectin and Insulin-Like Growth Factor I During Infancy were Associated with Markers of Metabolic Syndrome at Six Years of Age

Dahlgren Jovanna , Kjellberg Emma , Roswall Josefine

Objective: Metabolic programming occurs during early life and nutritional factors are known to have long-lasting influences on metabolic health. We investigate associations between insulin-like growth factor I (IGF-I), leptin and adiponectin during infancy and metabolic markers in the same children at six years of age.Method: The Swedish longitudinal Halland Health and Growth birth cohort study is population-based, origi...

hrp0092p1-196 | Fat, Metabolism and Obesity (1) | ESPE2019

Why are Patients with Obesity Due to Leptin Receptor Deficiency not Sufficiently Recognized? Prevalence Estimation Based on European Allele Frequencies and Thoughts on the Discrepancy

Kleinendorst Lotte , Abawi Ozair , van den Akker Erica , Van Haelst Mieke

Background: Biallelic loss of function (LoF) mutations in the leptin receptor gene (LEPR) cause a striking phenotype of early-onset severe obesity and hyperphagia. Additionally, hypogonadotropic hypogonadism, growth hormone deficiency, and/or hypothyroidism are often present. Currently, 19 European patients (all aged <30 years) are described in literature. As clinical trials investigating MC4R-agonist treatment are performed throughout Europe, ide...

hrp0092p1-197 | Fat, Metabolism and Obesity (1) | ESPE2019

You are What You Eat: Preliminary Evidence of Associations Between Dietary Habits and Oral Microbiota Composition in Early Childhood

Henderson Mélanie , Nicolau Belinda , Van Hulst Andraea , Simoneau Gabrielle , Barnett Tracie A. , Drapeau Vicky , Tremblay Angelo , Mathieu Marie-Eve , Paradis Gilles , Zappitelli Michael , Varin Thibaut , Marette André

Background: Oral microbiota composition and diversity differ between obese and non-obese individuals. However, the associations between lifestyle habits (implicated in the pathogenesis of obesity) and the oral microbiota remain uncertain, particularly among children.Objective: To explore the associations between oral microbiota diversity and lifestyle habits among 8-10 year-old children.Met...

hrp0092p1-198 | Fat, Metabolism and Obesity (1) | ESPE2019

Correlation of Serum Chemerin Concentrations with Obesity/Metabolic Syndrome Characteristics in Pre-Adolescents and Adolescents

Bacopoulou Flora , Koutroumpa Arsinoi , Zoi Vasiliki , Karatza Eleni , Karalis Vangelis , Markantonis Sophia , Siahanidou Tania

Background: Chemerin, a protein mainly synthesized in the adipose tissue and liver, belongs to the adipokines family and is implicated in signaling for adipocyte differentiation and lipolysis. From this point of view, chemerin can exert an important role in the regulation of various pathophysiological functions, including lipogenesis and metabolism.Objective: The aim of this study was to investigate the relationship betw...

hrp0092p1-199 | Fat, Metabolism and Obesity (1) | ESPE2019

Non-Alcoholic Fatty Liver Youth with Obesity

Ybarra Marina , Deboni Mariana , Franco Ruth Rocha , de Araújo Iana Manuelle , D'Alessandro Marcela Salum , Cominato Louise , Velhote Manoel Carlos Prieto , Sucena Silvia , Wang Marcia , Damiani Durval , Toma Ricardo Katsuya , Porta Gilda

Background: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease which occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into the most common liver disease seen in the pediatric population. NAFLD can be divided into non-alcoholic fatty liver (NAFL), which denotes bland steatosis, and non-alcoholic steatohepatitis (NASH), which is marked by steatosis and lobular inflammation and hepatoce...

hrp0092p1-200 | Fat, Metabolism and Obesity (1) | ESPE2019

Ferritin, an Indicator for Inflammation or Iron Storage in Obese Children?

Wu Wei , Yuan Jinna , Yu Yunxian , Shen Yu , Dong Guanping , Huang Ke , Zhang Li , Fu Junfen

Ferritin is a widely used iron storage indicator. At the same time, it is also viewed as an indicator of inflammation. Chronic low-grade inflammation in obese individual, especially in the one with metabolic disorders, related to comorbidities and poor prognosis. Both hyperglycemia and iron overload can induce inflammation and result in vascular endothelial dysfunction. To study the role of ferritin in obese children and its impact on artery and liver, the present study invest...

hrp0092p1-201 | Fat, Metabolism and Obesity (1) | ESPE2019

Serum Kisspeptin in Obese Children and its Relation to Glucose Metabolism

Stihinamsuwan Kochakorn , Poomthavorn Preamrudee , Mahachoklertwattana Pat , Chanprasertyothin Suwannee , Khlairit Patcharin , Pongratanakul Sarunyu

Background: The neuropeptide kisspeptin has recently been demonstrated to play a role in regulating energy balance and glucose metabolism. Previous studies showed a positive effect of serum kisspeptin in relation to glucose metabolism. These included negative association between serum kisspeptin and body mass index (BMI), homeostatic model assessment of insulin resistance (HOMA-IR) and plasma insulin. However, some studies reported conflicting results. Data on...

hrp0092p1-202 | Fat, Metabolism and Obesity (1) | ESPE2019

Visceral Adiposity Index as a Marker of Metabolic Risk in Survivors of Paediatric Hematopoietic Stem Cell Transplantation After Chemotherapy-Only Conditioning

Cima Luminita-Nicoleta , Nedelea Lavinia , Soare Iulia , Barbu Carmen Gabriela , Zaharia Cristina , Colita Anca , Fica Simona

Background: Hematopoietic stem cell transplantation (HSCT) recipients exhibit excess adiposity that may result in an increased metabolic risk. Studies have shown that BMI is a poor predictor of body fatness in pediatric HSCT survivors population where diminished lean mass has been documented. The visceral adiposity index (VAI) has recently been proposed as a predictor of cardio-metabolic risk in both adults and children. However, the predictive value of this i...

hrp0092p1-203 | Fat, Metabolism and Obesity (1) | ESPE2019

Serum Nonylphenol and Obesity in Children and Adolescents

Seo Moon Young , Kim Shin-Hye , Park Mi Jung

Background: Experimental models suggest that exposure to low dose nonylphenol could induce adiposity and promote adipocyte differentiation in mice. However, studies on the effect of nonylphenol exposure to human obesity have not been adequately studied.Objective: We investigated the associations of serum nonylphenol concentration with adiposity measures in Korean children and adolescents.Me...