hrp0098p2-104 | Fat, Metabolism and Obesity | ESPE2024

Silent Dangers: How Insulin Resistance and Trimethylamine N-Oxide Fuel Early Atherosclerosis in Obese Children. A preliminary study

Simina Mihuta Monica , Stoian Dana , Paul Corina

Introduction: Insulin resistance accelerates the onset of atherosclerosis and arterial stiffness in children. Trimethylamine N-oxide (TMAO), a gut-derived metabolite linked to cardio-metabolic issues in adults, could exacerbate these conditions in children as well. This study explores how insulin resistance and serum TMAO levels relate to vascular damage in obese children.Methods: We included 60 children aged 6 to 18, di...

hrp0095p1-142 | Multisystem Endocrine Disorders | ESPE2022

Two causes of short stature and delayed puberty in one patient: craniopharyngioma and celiac disease. A case report.

Simina MihutaMonica , Stoian Dana , Cepeha Cristina , Paul Corina

Introduction: Craniopharyngioma, a benign tumor, develops in the sellar/parasellar region. Diagnosis is usually late. Symptoms include severe headaches and vomiting, visual impairment, visual and olfactory hallucinations and at least one hormonal deficiency. Celiac disease is caused by an immune reaction triggered by gluten in the small intestine. Over time, due to inflammation, it causes malabsorbtion which can affect growth in children.<p class="abstext"...