hrp0084p2-575 | Thyroid | ESPE2015

Attention Deficit and Sluggish Cognitive Tempo Symptoms in Congenital Hypothyroidism: Results from a Case-Control Study

Esposito Annalisa , D'Acunzo Ida , Di Mase Raffaella , Giudice Ennio Del , Servera Mateu , Salerno Mariacarolina

Background: Despite neonatal screening, children with congenital hypothyroidism (CH) may still display behavioural problems such as inattention, distractibility, hyperactivity and restlessness.Objective and hypotheses: The aim of present study was to evaluate attention and sluggish cognitive tempo (SCT) symptoms in 32 children with CH compared to 32 matched healthy controls.Method: The study population consisted of 32 CH children a...

hrp0094p2-293 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Effects of GH replacement therapy on body composition and muscle health in children and adolescents with GH deficiency: one-year prospective case-control study.

Improda Nicola , Capalbo Donatella , Di Mase Raffaella , Di Pinto Rosita , Alicante Paola , Scalfi Luca , Salerno Mariacarolina ,

Background: The effects of GH deficiency (GHD) and GH replacement therapy (GHRT) on body composition and functional measures of physical fitness are largely unknown particularly in children.Study aim: To evaluate body composition, muscular strength and flexibility, and exercise tolerance in GHD children at baseline and after one-year GHRT.Patients and methods: We enrolled 19 children and adolescents with untreated ...

hrp0092p1-409 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (2) | ESPE2019

Long-Term Outcome in Young Women Treated for Central Precocious Puberty

Improda Nicola , Alfano Sara , Anselmi Federica , Gaeta Valeria , Bufalo Lorenzo , Santamaria Fabiana , Di Mase Raffaella , Salerno Mariacarolina

Background: GnRH-analogs (GnRHa) are the recommended treatment for Central Precocious Puberty (CPP). Despite a normal long-term outcome is generally reported, reproductive function and emotional sphere in adulthood are still poorly evaluated.Objective: To evaluate the general long-term outcome of young women with previous CPP treated with GnRHa.Patients and Methods: A cohort of 63 ...

hrp0092p2-287 | Thyroid | ESPE2019

Bone Homeostasis in Children with Subclinical Hypothyroidism: Effects of Two-years Treatment with Levothyoxine

Barbieri Flavia , Esposito Andrea , D'Acunzo Ida , Lorello Paola , Di Mase Raffaella , Improda Nicola , Capalbo Donatella

Background: Thyroid hormone plays a key role in bone mineral homeostasis and significant alterations in its circulating levels have been associated with an impairment in skeletal growth during childhood. To date, the effects of subclinical hypothyroidism (SH) on bones have not been studied and the management of this condition is still debated.Aim: To evaluate bone mineral density (BMD) in children with mild, persistent S...

hrp0086p1-p904 | Thyroid P1 | ESPE2016

Cardiac Size and Function in Children with Subclinical Hypothyroidism

Alfano Sara , Arcopinto Michele , Cerbone Manuela , Improda Nicola , Di Mase Raffaella , Ungaro Carla , Salzano Andrea , Cittadini Antonio , Salerno Mariacarolina

Background: The management of subclinical hypothyroidism (SH) is still challenging in particular for mild forms with TSH levels ranging between 4.5 and 10 mU/L.Objective and hypotheses: to compare left ventricular (LV) geometry and function of SH subjects and matched euthyroid controls, and to evaluate the effect of L-thyroxine (L-T4) therapy on cardiac parameters.Method: Thirty-six (36) children (19 females and 17 males), aged 8.6...

hrp0086p2-p939 | Thyroid P2 | ESPE2016

Five-Year Prospective Evaluation of Thyroid Function Test Evolution in Children with Hashimoto’s Thyroiditis Presenting with Either Euthyroidism or Subclinical Hypothyroidism

Aversa Tommaso , Corrias Andrea , Salerno Mariacarolina , Tessaris Daniele , Di Mase Raffaella , Valenzise Mariella , Corica Domenico , De Luca Filippo , Wasniewska Malgorzata

Background: It had never been investigated to now whether the course of thyroid function in Hashimoto’s thyroiditis (HT) may differ in the children who had presented with either euthyroidism or subclinical hypothyroidism (SH).Objective and hypotheses: To establish, by means of a 5-year prospective evaluation of 234 children with HT and no prognostic risk factors, whether thyroid status evolution over time may be conditioned by the biochemical patter...

hrp0084fc13.5 | Thyroid | ESPE2015

Effect of 2 Years of Treatment with Levothyroxine on Cardiovascular Risk Factors in Children with Mild Idiopathic Subclinical Hypothyroidism

Cerbone Manuela , Wasniewska Malgorzata , Alfano Sara , Capalbo Donatella , Di Mase Raffaella , Improda Nicola , De Luca Filippo , Salerno Mariacarolina

Background: The benefits of levothyroxine (L-T4) therapy in subjects with mild SH (TSH between 5 and 10 mU/l with normal FT4 values) are controversial. Current recommendations in adults suggest to start on treatment selected groups of subjects with mild SH and evidence of atherosclerotic CV disease. Data in children are lacking.Objective and hypotheses: To investigate the effect of L-T4 treat...

hrp0082p2-d1-593 | Thyroid | ESPE2014

Incidence of Thyroid Nodules in Children Affected by Hashimoto’s Thyroiditis: a 12-Year Survey of 567 Children

Longhi Silvia , Aversa Tommaso , Bal Milva , Cantasano Antonella , Cappa Marco , Cassio Alessandra , Corrias Andrea , D'Antonio Valeria , De Luca Filippo , Di Mase Raffaella , Gastaldi Roberto , Guzzetti Chiara , Loche Sandro , Salerno Mariacarolina , Maria Tronconi Giulia , Cristina Vigone Maria , Weber Giovanna , Radetti Giorgio

Background: Hashimoto’s thyroiditis (HT) has been linked to papillary cancer in adults but not in children and adolescents. Moreover, there is no agreement on the more appropriate frequency of thyroid ultrasound (TS) in the follow-up of children with HT.Objective and hypotheses: The aim of the study was to investigate the incidence of thyroid nodules and of thyroid cancer in a large group of children and adolescents (567) with HT followed-up for a m...

hrp0082p2-d2-604 | Thyroid (1) | ESPE2014

Levothyroxine Requirement in Congenital Hypothyroidism: 12-year Longitudinal Study

Vigone Maria Cristina , Lapolla Rosa , Delvecchio Maurizio , Salerno Mariacarolina , Wasniewska Malgorzata , Popolo Pietro Pio , Mussa Alessandro , Tronconi Giulia Maria , Di Mase Raffaella , D'Acunzo Ida , Falcone Rosa Maria , Corrias Andrea , De Luca Filippo , Weber Giovanna , Cavallo Luciano , Faienza Maria Felicia

Background: The replacement therapy with levo-thyroxine (LT4) in congenital hypothyroidism (CH) aims to ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence.Objective and hypotheses: i) To evaluate LT4/kg per day requirement from diagnosis until 12 years of age; ii) to assess any differences in relation to the different etiology of CH as concern...

hrp0084p3-1175 | Thyroid | ESPE2015

Final Height in Italian Patients with Congenital Hypothyroidism Detected by Neonatal Screening: An Observational Study Over 20 Years

Delvecchio Maurizio , Salerno Mariacarolina , Vigone Maria Cristina , Wasniewska Malgorzata , Lapolla Rosa , Popolo Pietro Pio , Tronconi Giulia Maria , Di Mase Raffaella , De Luca Filippo , Cavallo Luciano , Weber Giovanna , Faienza Maria Felicia

Background: Linear growth in patients with congenital hypothyroidism (CH) born in 1970s and 1980s is reported normal.Objective and hypotheses: To evaluate whether the earlier diagnosis and the higher L-T4 starting dose lead to an improvement in growth and pubertal outcome over the last two decades.Method: Two-hundred and fifteen patients with permanent CH born in 1980s and 1990s (age at diagnosis 25.1&#177...