hrp0094p2-202 | Fat, metabolism and obesity | ESPE2021

The challenges faced in the management of Congenital Generalized Lipodystrophy.

Abdelmeguid Yasmine , Elashry Reham , Elsayed Shaymaa , Raafat Shaymaa ,

Background: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease. The prevalence has been reported to be 1 in 10million with around 500 cases worldwide. The absence of functional adipocytes results in storage of lipids in other tissues, including muscle & liver. The diagnosis of CGL is based on clinical data; however, there is phenotypic heterogeneity. Metreleptin injections cause decreased appetite & is beneficial in loweri...

hrp0095rfc8.5 | Diabetes and Insulin | ESPE2022

Impact of type 1 diabetes on the epicardial fat thickness in children and adolescents

Raafat Shaymaa , Elashry Reham , Adel Hani , Wafa Ehsan

Introduction: Diabetes mellitus has been shown to be a major risk factor for development of early adult onset cardiovascular disease (CVD). Therefore, early detection and management of CVD became a major concern for health care providers. Epicardial fat thickness (EFT) is considered a new marker of visceral adiposity. The increased epicardial adiposity does not only increase the cardiovascular risk but also is considered an established risk factor for appearan...