ESPE Abstracts

Background: Recombination-activating genes (RAG) 1 and 2 have a key role in adaptive immunity plasticity protecting against enormous diverse antigens [1]. RAG1/RAG2 defects result in several forms of primary immunodeficiencies (PI) which are, nowadays, increasingly treated by Hematopoietic Stem Cell Transplantation (HSCT) [1-3]. Both, PI and HSCT, predispose to autoimmune thyroid disease (AITD) which is otherwise uncommon in young children [4,5]. It is believe...

Introduction: Thyroid hormone (TH) is important for normal growth and function of kidneys [1,2]. Hypothyroidism decreases responsiveness to B-adrenergic stimulation resulting in diminished cardiac contractility, blood pressure, and vasodilator secretion leading to lower renal blood flow [3]. Glomerular filtration rate (GFR) can be reduced by up to 40% and a direct relationship between serum creatinine (SCr) and thyroid-stimulating hormone (TSH) levels was elic...

Introduction: The coexistence of asthma and obesity presents a significant clinical challenge, as both conditions independently contribute to systemic inflammation, metabolic dysregulation, and impaired respiratory function. Metabolic markers can potentially provide insights into the pathophysiological mechanisms that link obesity and asthma. The aimof this study was to investigate the association between metabolic markers, vitamin D and lung function in child...

Background: Obesity is highly prevalent in the MENA region, especially in children and it has been associated with neurodegeneration. We have undertaken corneal confocal microscopy (CCM) to assess for evidence of neurodegeneration in children with simple obesity and monogenic obesity (MC4R gene mutation) and further assessed the effect of glucagon-like peptide 1 agonist (GLP-1) therapy on corneal nerve regeneration.Methods:</stro...