hrp0095p1-56 | Diabetes and Insulin | ESPE2022

Curative effect contributors of exercise in type one diabetes: Irisin and Sestrin

Ceyhun Emre , Devran Sergen , Can Demirbaş Kaan , Çıkıkçı Alper , Güven Günver Mehmet , Güneş Kaya Didem , Bayramoğlu Elvan , Bayraktar Bülent , Quinn Maryanne , Olcay Evliyaoglu Saadet

Type 1 Diabetes (T1DM) is a chronic metabolic disease characterized by hyperglycemia due to absolute insulin deficiency as a result of autoimmune damage of pancreatic β cells. In its treatment, insulin, medical nutrition therapy and exercise is recommended. Although it is known that exercise contributes to disease control, the mechanism of these effects has not been fully clarified. It is thought that myokines such as irisin and sestrin, can be effective by secreting with...

hrp0097p1-40 | Diabetes and Insulin | ESPE2023

Neopterin and tryptophan pathways in children with type 1 diabetes: isoxanthopteridine as a marker of endothelial dysfunction

Evliyaoğlu Olcay , Özer Yavuz , Kıykım Ertuğrul , Serif Cansever Mehmet , Turan Hande , Bayramoglu Elvan , Ceyhun Emre , İşat Esra , Zübarioğlu Tanyel , Cigdem Aktuglu Zeybek Ayse

Introduct&idot;on: Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by damage to β cells in the pancreas. Neopterins and indolamine 2,3-dioxygenase (IDO) activity, which is shown by the ratio of kynurenine to tryptophan, can be used as an indicator in the regulation of cellular immunity. Oxidative stress produced by xanthine oxidoreductase has been shown to be associated with vascular endothelial dysfunction. It uses the conversion of p...