hrp0095fc5.6 | Adrenals and HPA Axis | ESPE2022

ACTH Stimulation Decreases Ischemia-Modified Albumin Levels In Vivo

Muratoglu Sahin Nursel , Esen Senem , Savas Erdeve Senay , Budak Fatma , Neselioglu Salim , Erel Ozcan , Cetinkaya Semra

Introduction: The production of ischemia-modified albumin (IMA) is associated with the production of reactive oxygen species modifying the metal-binding sites of albumin. IMA is considered a non-specific early biomarker in the evaluation of oxidative stress status. Cortisol is known to trigger anti-inflammatory actions through genomic and non-genomic pathways that eventually lead to decreased production of cytokines, chemokines, and inducible nitric oxide synt...

hrp0094p2-355 | Pituitary, neuroendocrinology and puberty | ESPE2021

Did Central Precocious Puberty Increase in COVID 19 Pandemic?

Orman Burce , Esen Senem , Keskin Meliksah , Sahin Nursel Muratoglu , Savas Erdeve Senay , Cetinkaya Semra ,

Background: The timing of puberty in children is occurring at an increasingly early age. During the COVID19 pandemic period, children experienced changes such as epidemic stress, sedentary life, and weight gain.Aim: To make a retrospective evaluation of the incidence of newly diagnosed central precocious puberty (CPP) during the first months of COVID-19. And to compare these corresponding data with the previousy ear....

hrp0095p2-249 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

5 Alpha Reductase Deficiency as the Etiology of Primary Amenorrhea in a Girl with Thalassemia Major

Esen Senem , Orman Burçe , Sezer Abdullah , Bakır Abdullatif , Keskin Melikşah , Savaş Erdeve Şenay , Çetinkaya Semra

Introduction: Beta thalassemia major (βTM) is an autosomal recessive anemia characterized by a defect in the production of the β-globin chain of hemoglobin. There may be endocrine problems secondary to hemochromatosis in the clinical follow-up of the patients. Here, a case who was followed up with the diagnosis of βTM, consulted for primary amenorrhea and diagnosed with 5-alpha reductase deficiency (5ARD) is presented and clinical follow-up expe...

hrp0095p1-122 | Growth and Syndromes | ESPE2022

A Case of Derivative Chromosome 1 Accompanied by Y Chromosome Deletion

Çetinkaya Semra , Görkem Erdoğan Nilay , Esen Senem , Özkaya Dönmez Beyhan , Arasli Yilmaz Aslihan , Elmaoğullari Selin , Okur İclal , Kurnaz Erdal , Savaş Erdeve şenay , Bakir Abdullatif

Introduction: Derivative chromosome is a rearrangement involving two or more chromosomes or the presence of multiple abnormalities in a single chromosome and always contains intact centromere. Segmental anomalies such as inversion or translocation in derivative chromosome may result in partial duplication or deletion during meiosis. Chromosomal translocations usually result in miscarriage and multiple anomalies (common neurodevelopmental defects, growth retard...