hrp0095wg5.2 | ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG) Symposium | ESPE2022

Pubertal induction of female delayed puberty: when and how

Bonomi Marco , Federici Silvia , Goggi Giovanni

Delayed puberty (DP) is defined as a retardation of sexual maturation beyond the expected age, which conventionally is between 8 and 13 years in females. Since DP due to hypogonadism requires a specific treatment, it is crucial to promptly define the underlying pathogenesis and identify a tailored program of care. Hormonal therapy is essential to promote the development of secondary sexual characteristics, bone, muscle, and social, sexual, and psychologic skills. Despite the o...

hrp0094p2-358 | Pituitary, neuroendocrinology and puberty | ESPE2021

Pubertal induction in girls with hypogonadism: preliminary prospective data of efficacy in patients with/without initial overnight estrogen replacement

Rodari Giulia , Federici Silvia , Persani Luca , Arosio Maura , Bonomi Marco , Giavoli Claudia ,

Background: Pubertal induction in girls with hypogonadism through estrogen replacement therapy (ERT) aims at the development of secondary sexual characteristics, cognitive functions, uterine growth and maturation, bone mass accrual and linear growth. To date, the best induction regimen, capable of assuring both physiological gradual progression through Tanner stages and effective uterine development, is still to be established.Patients a...