hrp0097p1-341 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Correlation Analysis of Genotypes and Phenotypes of 91 young male paediatric patients with congenital hypogonadotropic hypogonadism

Fu Dongxia , Chen Jiajia , Wei Haiyan

Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which is the master hormone regulating the reproductive axis. CHH can be divided into Kallmann syndrome (KS) with dysosmia and normosmic Congenital hypogonadotropic hypogonadism (nCHH) according to the presence or absence of an olfactory disorder.Methods:</...

hrp0097p1-164 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Insight into Gut Microbiota of Normal Body Mass Index Girls with Idiopathic Precocious Puberty

Lin Yifan , Fu Dongxia , Yuan Shuxian , Wei Haiyan

Key words: precocious puberty; idiopathic central precocious puberty; premature thelarche; gut microbiota; HPG axisBackground: The incidence of precocious puberty and obesity has increased significantly after the COVID-19 epidemic, and the specific cause is not clear. There seems to be a causal relationship between obesity and idiopathic central precocious puberty. A few studies have shown that the changes of gut microbi...

hrp0097rfc6.1 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Clinical application of LH cut-off value in the diagnosis of CPP according to the international consensus

Lin Yifan , Zhang Yingxian , Fu Dongxia , Yuan Shuxian , Hou Yuwei , Wei Haiyan

Keywords: Central precocious puberty; Luteinizing hormone; Precocious puberty Gonadotropin-releasing hormone agnosit testBackground: 2019 International consensus on central precocious puberty (CPP) proposed that random serum luteinizing hormone (LH) ≥0.83IU/L and < 0.2IU/L has important reference value for the establishment or exclusion of CPP, but there is no corresponding diagnostic criteria in China. This study ...