hrp0095p1-235 | Diabetes and Insulin | ESPE2022

Etiology-based diagnosis of pediatric patients with atypical diabetes using routine and omic-based phenotyping and genotyping: results from the GENEPEDIAB study

Welsch Sophie , Gallo Paola , Beckers Dominique , Lebrethon Marie-Christine , Mouraux Thierry , Seret Nicole , Lysy Philippe

Objective: To provide etiology-based diagnostics to pediatric patients with diabetes in Belgium using routine clinical phenotyping and thorough genotyping.Methods: A Belgian GENEPEDIAB study consortium was created to screen, using routine diagnostic tools, for monogenic forms of diabetes in pediatric patients followed in convention centers for type 1 or type 2 diabetes, while presenting atypical biological and clinical f...

hrp0097p1-439 | Diabetes and Insulin | ESPE2023

Determinants And Characteristics Of Insulin Dose Requirements In Children And Adolescent With New-Onset Type 1 Diabetes: Insights From The INSENODIAB Study

Beckers Maude , Lysy Philippe , Polle Olivier , Bernard Noémie , Gallo Paola

Aims: In children with new-onset type 1 diabetes mellitus (T1D), insulin dose regimens vary substantially. According to current ISPAD recommendations, the initial total daily dose (TDD) should range from 0.7 to 1.0 IU/kg BW/day. Adjusting TDD to achieve normal blood glucose concentration can take several days. The primary objectives of our INSENODIAB (INsulin SEnsitivity in New Onset type 1 DIABetes) study were to assess how patient characteristics influence i...