hrp0082p3-d3-687 | Bone (2) | ESPE2014

Endocrinological Assessment of Children with Bronchiectasis

Ozgen Ilker Tolga , Cakir Erkan , Gedik Hakan , Gokce Selim , Atilla Nursoy Mustafa , Cesur Yasar

Background: Bronchiectasis is a result of recurrent pulmonary infections and chronic inflammation.Objective and hypotheses: Chronic inflammation may lead some endocrinological disorders. The consequences of the bronchiectasis on the endocrinological system and on the bone health in childhood were investigated in this study.Method: The medical records of the 64 children with bronchiectasis (32 females and 32 males) at the mean age o...

hrp0082p3-d1-704 | Diabetes | ESPE2014

A Case with Neonatal Diabetes and Congenital Hypothyroidism due to Glis3 Gene Deletion

Tolga Ozgen Ilker , Kucukkoc Mehmet , Houghton Jayne , Gokce Selim , Cesur Yasar

Background: Neonatal diabetes is a rare disease having usually a genetic origin. Defects in KCNJ11, ABCC8, INS, GCK, and PDX1 genes are more frequent and may lead non-transient, non-syndromic neonatal diabetes, whereas defects in PTF1A, FOXP3, EIF2AK3, GLIS3, RFX6, and NEUROD1 genes are very rare and may lead neonatal diabetes as a part of a syndrome.Objective and hypotheses: We present a patient with GLIS3 ge...