hrp0082p1-d2-250 | Thyroid (1) | ESPE2014

In Patients with Chronic Autoimmune Thyroiditis, Investigation of the Effects of Functions of Regulatory T Cells and Vitamin D

Siklar Zeynep , Karatas Deniz , Dogu Figen , Kocaay Pinar , Hacihamdioglu Bulent , Ikinciogullari Aydan , Berberoglu Merih

Background: Treg cells are characterized by expression of Foxp3 molecule that serve as keys in the maintenance of peripheral tolerance and in controlling the immune response. The exact role of Treg cells in the pathogenesis of CAT has not been recognized yet.Objective and hypotheses: It is suggested that vitamin D is one of the factors that can regulate the function of Treg cells. In this study, the relationship between Treg cells (levels and expression)...

hrp0086rfc9.5 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016

Non-Mody Monogenic Diabetes: A Very Heterogenous and Problematic Group of Diabetes

Siklar Zeynep , De Franco Elisa , FlanagaN Sarah , Ellard Sian , Ceylaner Serdar , Boztug Kaan , Dogu Figen , Ikinciogullari Aydan , Kuloglu Zarife , Kansu Aydan , Berberoglu Merih

Background: Monogenic diabetes represents a group of disorders resulting from a single gene defect leading to disruption of insulin secretion or a reduction in the number of beta cells. Despite the classification of monogenic diabetes according to age of onset, with neonatal DM (<6 months of age) and maturity onset diabetes of young (MODY) (>6 months and <25 years of age); not every case can be classified into those groups.Objective and hypot...

hrp0084p3-1231 | Thyroid | ESPE2015

Angioneurotic Oedema with Antithyroid Drugs in Thyroid Storm: What is the Best Therapeutic Option

Bilir Pelin , Isakoca Mehmet , Ikinciogullari Aydan , Dogu Figen , Haskaloglu Sule , Corapcioglu Demet , Emral Rifat , Fitoz Suat , Yildiz Adalet Elcin , Kir Metin , Bahadir Gulnur Gollu , Turedi Bilge , Dindar Huseyin

Background: Graves disease is the most common cause of hyperthyroidism in children. The frequency of the disease increases with age, peaking during adolescence.Thyroid storm is a rare but critical, ilness that can lead to multiorgan failure and carries a high death rate. Antithyroid drugs are usually recommended as the initial treatment and are generally well tolerated. Although current treatment options include radioactive iodine, but long term complications of thyroid irradi...