hrp0095p1-434 | Diabetes and Insulin | ESPE2022

Role of glucose variability on linear growth in children with Type 1 Diabetes

Castorani Valeria , Blasetti Annalisa , Polidori Nella , Mastromauro Concetta , Mascioli Ilaria , Chiarelli Francesco , Giannini Cosimo

Objective: Linear growth is impaired in children with type 1 diabetes (T1D) and poor metabolic control. A good metabolic control is a key therapeutic goal to prevent vascular complications but also for ensuring an appropriate anthropometric development during childhood. In this study, we aimed to identify and characterize the effects of glycemic variability on linear growth in children with T1D.Methods: Data from 144 pre...

hrp0097p1-202 | Adrenals and HPA Axis | ESPE2023

Increased adiposity and insulin resistance negatively affect growth in pre-pubertal heterozygote carriers of 21-Hydroxylase deficiency

Mascioli Ilaria , Mastromauro Concetta , Lauriola Federico , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: 21-Hydroxylase deficiency (21-OHD) is the archetype of congenital adrenal hyperplasia (CAH). Deficiency of 21-Hydroxylase results in an impairment of cortisol synthesis, which is critical in stressful conditions when higher output is required to restore homeostasis. In addition, an increased androgen production, might results in undesirable manifestations of hyperandrogenism, as menstrual abnormalities, infertility and cosmetic annoyances and gro...

hrp0097p1-80 | Fat, Metabolism and Obesity | ESPE2023

Leukocyte, platelet counts and the neutrophil-to-lymphocyte ratio (NLR) are related to insulin resistance in obese and overweight children

Lauriola Federico , Mastromauro Concetta , Mascioli Ilaria , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Background and aims: The development of insulin resistance (IR) may be influenced by inflammation in overweight/obese individuals. To identify indicators of IR, new markers of inflammation and systemic inflammation such as leukocyte (WBC) and platelet counts (PLT), the neutrophil-to-lymphocyte ratio (NLR) have been suggested. This study aims to investigate the association between these markers and IR in a group of overweight and obese.<s...