ESPE Abstracts

Introduction: Diabetic nephropathy (DN) is one of the most frequent and severe complications of diabetes mellitus and a leading etiological cause of chronic kidney disease. Early diagnosis and treatment are essential to prevent further deterioration of kidney function. Albuminuria has been considered to be the clinical hallmark of diabetic kidney disease and is used for its diagnosis and follow-up. Although microalbuminuria is a marker established in the clini...

Background: STAT1 mutations can cause an extensive spectrum of disease, varying from severe bacterial and viral infections to mild disseminated mycobacterial disease, also chronic mucocutaneous candidiasis. Many patients present with autoimmune manifestations as type 1 diabetes, hypothyroidism and systemic lupus erythematosus. There are risks of cancers and cerebral aneurysms.Aim: To present the clinical manifes...

Aim: To present some therapeutic difficulties in patients with congenital generalized lipodystrophy (CGL) - a rare autosome recessive disorder characterized by complete absence of adipose tissue. For many years therapy was aimed only at metabolic consequences. In the past few years new pathophysiologic treatment has become available.Methods and materials: We present four girls – currently 25, 22, 16 and 15 years ol...