hrp0094p1-69 | Diabetes B | ESPE2021

Oxidized lipid-associated protein damage in children and adolescents with type 1 diabetes mellitus: new diagnostic/prognostic clinical markers.

Kostopoulou Eirini , Kalaitzopoulou Electra , Papadea Polyxeni , Skipitari Marianna , Gil Andrea Paola Rojas , Spiliotis Bessie , Georgiou Christos ,

Background: Type 1 diabetes mellitus (DM1), a chronic metabolic disorder of autoimmune origin, has been associated with oxidative stress (OS), which plays a central role in the onset, progression and long-term complications of DM1. The markers of OS lipid peroxidation products, lipid hydroperoxides (LOOH), and also malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively),...