Previous issue | Volume 94 | ESPE2021

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

ePoster Category 1

Diabetes B

hrp0094p1-61 | Diabetes B | ESPE2021

Timing of Hypoglycaemia in Patients with Hyperinsulinism (HI): Extension of the Digital Phenotype

Worth Chris , Harper Simon , Salomon-Estebanez Maria , O’Shea Elaine , Nutter Paul , Dunne Mark J , Banerjee Indraneel ,

Background: Hyperinsulinism (HI) due to excess and dysregulated insulin secretion is the most common cause of severe and recurrent hypoglycaemia in childhood. High cerebral glucose utilisation in the early hours results in high risk of hypoglycaemia for people with diabetes and carries a significant risk of brain injury. Prevention of hypoglycaemia is the cornerstone of management for HI but the risk of hypoglycaemia at night or indeed the timing of hypoglycae...

hrp0094p1-62 | Diabetes B | ESPE2021

Epidemiology of type 1 diabetes in children and adolescents: a 50-year, single center experience

Vuralli Dogus , Ozon Z. Alev , Gonc E. Nazli , Ardicli Didem , Jalilova Lala , Gulcek Omer Nazım , Alikasifoglu Ayfer ,

Introduction: Global variations in epidemiology of type 1 diabetes (T1D) exist worldwide. This study is designed to determine the demographic and clinical characteristics of T1D in the past three decades, and to analyze changing trends in epidemiology over the past 50 years.Methods: Epidemiological and clinical characteristics of 925 patients with T1D were analyzed in three decades between 1991 and 2019. In addition, pre...

hrp0094p1-63 | Diabetes B | ESPE2021

Comparison of triglyceride and glucose index and homeostatic model assessment for insulin resistance in children and adolescents with type 2 diabetes mellitus

Seo Yoon Jong , Kim Eun Young , Yi Kyung Hee , Shim Young Suk , Hwang Il Tae ,

Background: Triglyceride and glucose (TyG) index is significantly associated with higher risk of developing type 2 diabetes mellitus (T2DM). The mechanism of the role of TyG index in the development of T2DM is not clear. There are few studies on the relationship between the TyG index and homeostatic model assessment of insulin resistance (HOMA-IR).Aims: To elucidate the role of the TyG index, studies are needed on the association between...

hrp0094p1-64 | Diabetes B | ESPE2021

Initial Neutrophil/Lymphocyte and Lymphocyte/Monocyte Ratios Can Predict Future Insulin Need in Newly Diagnosed Type 1 Diabetes Mellitus

Erbaş Ibrahim Mert , Hajikhanova Aygun , Besci Ozge , Acinikli Kubra Yuksek , Demir Korcan , Bober Ece , Abacı Ayhan ,

Background: The exact mechanism of the partial clinical remission in type 1 diabetes mellitus (T1DM) has not been elucidated yet. The severity of the inflammation at the time of diagnosis may have an impact on the occurrence or duration of this phase.Objective: We aimed to investigate the relationship between hematological inflammatory parameters at the time of diagnosis in children and adolescents with T1DM and the need...

hrp0094p1-65 | Diabetes B | ESPE2021

Efficacy of Use of Continuous Glucose Monitoring System in patients with Congenital Hyperinsulinism

Tropeano Yesica , Purushothaman Preetha , Gilbert Clare , Morgan Kate , Doodson Louise , Dastamani Antonia ,

Background: Hypoglycaemic episodes in patients with Congenital Hyperinsulinism (CHI) are not always detected due to the intermittent measurement of blood glucose concentrations, particularly the asymptomatic episodes. Detecting and treating these episodes is important for prevention of hypoglycaemic brain injury. Although the Continuous Glucose Monitoring System (CGMS) is widely used in adults and children with diabetes, the use in patients with CHI remains li...

hrp0094p1-66 | Diabetes B | ESPE2021

Mortality in children with monogenic diabetes

Globa Eugenia , Zelinska Natalia , Franco Elisa De , Houghton Jayne , Johnson Matthew , Ellard Sian ,

Background: In this study we investigated mortality in children with monogenic diabetes.Methods: Within the Ukrainian Pediatric Diabetes Register (UPDR) the number of children with type 1 diabetes mellitus (DM1) 0-17 y.o. in 2019 was 9860 (1 in 769), with DM2 - 36 (1 in 210,547) with neonatal DM (NDM) - 66 (1 in 115,000), with MODY - 40 cases (1 in 114,844). We used targeted next generation sequencing (tNGS) of all known...

hrp0094p1-67 | Diabetes B | ESPE2021

The Molecular Genetic Etiology by Whole Exome Sequence Analysis in Cases With Familial Type 1 Diabetes Mellitus without HLA Haplotype Predisposition or Incomplete Predisposition

Cem Yılmaz ğur , Evin Ferda , Onay Huseyin , Ozen Samim , Darcan Şukran , Gokşen Damla ,

Introduction: Family history is observed in approximately 10% of the cases with type 1 diabetes mellitus (T1DM). The most important gene that determines susceptibility is the human leukocyte antigen complex (HLA) on chromosome 6. In HLA genes; specific combinations of alleles at DR3, DR4, DRB1, DQA1 and DQB1 locus either predispose or protective for T1DM. In this study, we aimed to investigate the molecular genetic etiology by whole exome sequence (WES) analys...

hrp0094p1-68 | Diabetes B | ESPE2021

Birth weight and diazoxide unresponsiveness strongly predict the likelihood of congenital hyperinsulinism due to a mutation in ABCC8 or KCNJ11

Hewat Thomas , Yau Daphne , Jerome Joseph , Laver Thomas , Houghton Jayne , Shields Beverley , Flanagan Sarah , Patel Kashyap ,

Background: Hyperinsulinism is characterised by inappropriate insulin secretion during hypoglycaemia. Mutations in the KATP channel genes, ABCC8 and KCNJ11, are the most common cause of persistent congenital hyperinsulinism. The diagnosis of KATP hyperinsulinism is key for the clinical management of the condition.Aim: We aimed to determine the clinical features that help to identify KATP hyperinsulinism...

hrp0094p1-69 | Diabetes B | ESPE2021

Oxidized lipid-associated protein damage in children and adolescents with type 1 diabetes mellitus: new diagnostic/prognostic clinical markers.

Kostopoulou Eirini , Kalaitzopoulou Electra , Papadea Polyxeni , Skipitari Marianna , Gil Andrea Paola Rojas , Spiliotis Bessie , Georgiou Christos ,

Background: Type 1 diabetes mellitus (DM1), a chronic metabolic disorder of autoimmune origin, has been associated with oxidative stress (OS), which plays a central role in the onset, progression and long-term complications of DM1. The markers of OS lipid peroxidation products, lipid hydroperoxides (LOOH), and also malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively),...

hrp0094p1-70 | Diabetes B | ESPE2021

Change in HbA1C predicts future abnormal Oral Glucose Tolerance Tests in children and adolescents with Cystic Fibrosis.

Aftab Sommayya , Ghauri Rooha Ijaz , Drew Samantha , Meek Hannah , Peters Catherine , Amin Rakesh ,

Background: Oral glucose tolerance test (OGTT) is the screening test of choice for Cystic Fibrosis Related Diabetes (CFRD). HbA1C is considered unreliable in diagnosing CFRD because of increased cell turn over in children and adolescents with Cystic Fibrosis (CF).Objective: To determine the validity of HbA1C as a predictive tool for future abnormal OGTT in CF.Material & Methods: Data were colle...