hrp0089p2-p095 | Diabetes & Insulin P2 | ESPE2018

Impaired Adrenal Function in Pediatric Patients with Diabetes Mellitus Type 1 Evaluated with Low-Dose Synacthen Test

Kalymniou Marialena , Dimitriadou Meropi , Slavakis Aris , Christoforidis Athanasios

Background: Primary adrenocortical insufficiency (AddisonÂ’s disease) is reported to be five more times frequent in adult patients with type 1 diabetes mellitus (T1DM) than in the general population with a multifactorial aetiology involving autoimmune, inflammatory and metabolic mediators. Recent data indicate that more than half of children with T1DM show subnormal cortisol response. Subnormal cortisol response may impair the metabolic control of patients with T1DM as the...