hrp0092p2-134 | Fat, Metabolism and Obesity | ESPE2019

Tumor Necrosis Factor Alpha in Metabolic Syndrome Development in Children

Ben-Skowronek Iwona , Kapczuk Iga , Mroczek Wacinska Joanna

Background: Tumor necrosis factor alpha (cachexin) is a cell signaling cytokine involved in systemic inflammation process. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF alpha is the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, an...

hrp0086p2-p530 | Fat Metabolism and Obesity P2 | ESPE2016

Vascular Endothelial Growth Factor as The Predictor Microangiopathy in Obese and Diabetic Children

Ben-Skowronek Iwona , Kapczuk Iga , Stapor Natalia , Banecka Bozena

Background: Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body.Objective and hypotheses: The...

hrp0092p2-286 | Thyroid | ESPE2019

Management of Childhood Thyroid Nodules in Children a Large Group of Cases From a Single Center

Sieniawska Joanna , Makuch Magdalena , Mlodawska Anna , Maslowska Kamila , Krawczyk Sylwia , Kapczuk Iga , Ben-Skowronek Iwona

Background: Thyroid nodules are quite common in the adult population (13%)but are relatively rarely diagnosed in childhood (0.2-5%).There is a significantly higher risk of malignancy of paediatric thyroid nodules than that in adult patients. The authors of this publication present the observations of the occurrence, diagnosis, and treatment of patients with thyroid nodules in the Department of Pediatric Endocrinology and Diabetology, Medical University...