hrp0082p1-d1-61 | Diabetes | ESPE2014

Evaluation of S-100B, Antioxidant and Oxidative Capacity Before and After the Treatment in Children with Diabetic Ketoacidosis

Kaya Cemil , Atas Ali , Aksoy Nurten

Background: Diabetic ketoacidosis is a serious condition with high rates of morbidity and mortality in children with type 1 diabetes mellitus. Calcium-binding protein S100B is a cell damage marker glycopeptide that is mainly produced by astrocytes. Oxidative stress might be defined as an imbalance between anti-oxidative defense of the body and free radical production responsible for peroxidation of lipid layer of cell walls.Objective and hypotheses: In p...

hrp0084p3-1127 | Pituitary | ESPE2015

Pituitary Stalk Interruption Syndrome: A Case of an Infant

Kendirci Havva Nur Peltek , Kaya Zafer

Background: Pituitary Stalk Interruption Syndrome (PSIS) is a rare congenital abnormality of the pituitary that is responsible for anterior pituitary deficiency. It is characterized by a classic triad of interrupted pituitary stalk, absent or ectopic posterior pituitary, and anterior pituitary hypoplasia or aplasia. Hypothalamic hypothyroidism, hyperprolactinemia and deficiency of anterior pituitary hormones are typical characteristics. Clinical presentation varies according t...

hrp0097p2-182 | Diabetes and Insulin | ESPE2023

Evaluation of clinical outcomes in children and adolescents with type 1 diabetes switching from Insulin Glargin to Insulin Detemir

Turan Hande , Kaya Didem , Ercan Oya

Basal-bolus insulin therapy is currently, the most common treatment modality in children and adolescents with type 1 diabetes mellitus (T1DM) worldwide. Insulin glargine and detemir are two different molecules, produced with small modifications, of human insulin. In this prospective longitudinal study, we aimed to compare HbA1c, time in range in CGM, basal insulin doses and hypoglyccemia frequencies in children and adolescents with T1DM who underwent switching from insulin det...

hrp0086p1-p477 | Fat Metabolism and Obesity P1 | ESPE2016

Renal Involvement ın Obese Children and Adolescents

Kaya Mehmet Sirin , Anık Ahmet , Unuvar Tolga , Sonmez Ferah

Background and aim: Epidemiologic studies have been shown that obesity increases the risk of renal disease and it impact on prognosis. In this study, we aimed to investigate both glomerular and tubular involvement in asymptomatic obese children and to investigate the association of metabolic-anthropometric parameters with renal parameters.Material-method: Children with BMI ≥95th percentile and diagnosed as primary obesity (n=43) were inclu...

hrp0086p1-p611 | Growth P1 | ESPE2016

IGFALS Gene Deletion in a Family with Short Stature

Haliloglu Belma , Losekoot Monique , Kaya Avni , Wit Jan-Marteen

Background: ALS deficiency is characterized by mild short stature, delayed puberty, low serum IGF1, low serum IGFBP3 and undetectable serum ALS levels.Case: A 11.3 years old boy presented with short stature. He was born at term to consanguineous parents and the birth weight was unknown. On physical examination, his height and weight were 130.5 cm (−2.33 SDS) and 25.2 kg (−2.36 SDS) and he was prepubertal. The routine laboratory tests were nor...

hrp0084p2-489 | Hypo | ESPE2015

The Effectiveness of Sirolimus in a Newborn with Hyperinsulinaemic Hypoglycaemia

Haliloglu Belma , Tuzun Heybet , Flanagan Sarah , Kaya Avni , Celik Muhittin

Background: Hyperinsulinaemic Hypoglycaemia (HH) is a rare genetic disease and the treatment of HH in cases with unresponsiveness to medical therapy is subtotal pancreatectomy. In a recent study, the authors showed that sirolimus could be an alternative treatment in these patients. We aimed to evaluate the effectiveness of sirolimus in a newborn with HH.Case: A 10 day-old neonate presented with hyperinsulinaemic hypoglycaemia (glucose: 26 mg/dl, insulin:...

hrp0084p3-755 | Diabetes | ESPE2015

Severe Hypertriglyceridaemia in a Child with Severe Diabetic Ketoacidosis

Karaguzel Gulay , Polat Recep , Kaya Gulay , Yilmaz Semra Atasoy

Background: Severe hypertriglyceridemia (HTG) is a very rare complication of childhood diabetic ketoacidosis (DKA). The exact mecanism is unclear but transient insulin deficiency may cause a decrease in the activity of lipoprotein lipase. We report a case of girl with DKA and HTG.Case report: A 14-year-old girl, previously healthy and nonobese, presented with DKA following two months malaise, two weeks of polyuria and polydipsia. She was found to have DK...

hrp0084p3-1088 | Perinatal | ESPE2015

Leptin and Neuropeptide Y Levels in Newborns

Kaya Avni , Orbak Zerrin , Polat Ismail , Polat Harun , Gumusdere Musa

Background: Several studies have investigated leptin and NPY levels in children, but the information for newborns in the literature is limited.Objective and hypotheses: The aim of this study was to determine leptin and neuropeptide Y (NPY) levels in between 14 and 28-days newborns.Method: This prospective study was performed in the Erzurum Atatürk University Medical Faculty Research Hospital Neonatal Clinic, Turkey, between Ju...

hrp0084p3-1188 | Thyroid | ESPE2015

Intrathyroidal Ectopic Thymic Tissue Mimicking a Thyroid Nodule: A Report of Three Paediatric Cases

Karaguzel Gulay , Kaya Serpil , Eyupoglu Ilker , Turgutalp Havvanur , Okten Aysenur

Background: Intrathyroidal ectopic thymic tissue is one of the rarest congenital abnormalities. Ectopic thymus tissue can be detected in various locations from the mouth or the base of the skull to the superior mediasteneum. We report here three cases of intrathyroidal ectopic thymus tissue who presented as thyroid nodules in different ages.Cases: Case 1: a 10-year-old girl had a guatr and her thyroid function tests were normal. Thyroid US showed a hypoe...

hrp0095p1-321 | Growth and Syndromes | ESPE2022

A Novel IGF2 Gene Variant of Paternal Origin Causing the Silver-Russell Syndrome Phenotype

Sarıkaya Özdemir Behiye , Sezer Abdullah , Savaş Erdeve Şenay , Çetinkaya Semra

Introduction: Silver-Russell syndrome (SRS) is a rare, well-defined genetic disease characterized by intrauterine and postnatal growth retardation, short stature, triangular face, relative macrocephaly and body asymmetry. The most common molecular pathologies are loss of methylation (50%) of the imprinting center in the p15.5 region of the paternal 11th chromosome and maternal uniparental disomy of the 7th chromosome (5-10%). The IGF2 (insulin-like growth fact...