hrp0089p2-p088 | Diabetes & Insulin P2 | ESPE2018

Relationship Between Residual Endogenous Insulin Secretion and Glycemic Control in Japanese Children and Adolescents with Type 1 Diabetes

Musha Ikuma , Kawana Hiroshi , Akatsuka Junya , Ohtake Akira , Amemiya Shin , Kikuchi Toru

Background: Difficulty of glycemic control varies among subjects with type 1 diabetes (T1D). Influence of residual endogenous insulin detected by serum C-peptide (CPR) levels has noted to be on glycemic control. Flush glucose monitoring (FGM) detects glucose concentration in intercellular fluid (sensor glucose) every 15 minutes to reveal daily glucose profiles.Aims: We tried to clarify the relationship between serum CPR and the excursion of blood glucose...

hrp0089p1-p116 | Fat, Metabolism and Obesity P1 | ESPE2018

Rapid BMI Gain During Later Infant Accelerates Skeletal Maturation at Prepubertal Obese Children

Kikuchi Toru , Nagasaki Keisuke , Ogawa Yohei , Abe Yuki , Musha Ikuma , Ohtake Akira

Objective: The aim of this study was to reveal the increase of BMI during later infant related to skeletal maturation in prepubertal obese boys.Subjects and Methods: The subjects were 63 Japanese 10-years old obese boys. Height and weight were measured. Bone age (BA) of left hand-wrist radiographs was assessed using RUS score of the Japanese-standardized Tanner-Whitehouse 2 method. Weight and length or height at birth, 1.5, 3 and 6 years old were obtaine...

hrp0084p1-90 | Growth | ESPE2015

Silver-Russell Syndrome without Body Asymmetry in Three Patients with Duplications of Maternally Derived Chromosome 11p15 Involving CDKN1C

Nakashima Shinichi , Kato Fumiko , Kosho Tomoki , Nagasaki Keisuke , Kikuchi Toru , Kagami Masayo , Fukami Maki , Ogata Tsutomu

Background: Silver-Russell syndrome (SRS) is a congenital developmental disorder characterised by pre- and post-natal growth failure, relative macrocephaly, hemihypotrophy, and fifth-finger clinodactyly. Recent studies have shown that gain-of-function mutations of CDKN1C result in IMAGe syndrome (IMAGeS) characterized by intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and male genital abnormalities, whereas less severe gain-of-function mut...

hrp0092rfc1.1 | Diabetes and Insulin Session 1 | ESPE2019

Low Prevalence of Maternal Microchimerism in Japanese Children with Type 1 Diabetes

Ushijima Kikumi , Kikuchi Nobuyuki , Kikuchi Toru , Kawamura Tomoyuki , Urakami Tatsuhiko , Amemiya Shin , Ogata Tsutomu , Yokota Ichiro , Sugihara Shigetaka , Fukami Maki

Background: Vertical transfer of maternal cells to the fetus via the placenta leads to maternal microchimerism (MMc) in children. Previous studies from USA have shown that the prevalence and degree of MMc was significantly higher in patients with type 1 diabetes (T1D) than in their unaffected siblings and control individuals. To date, however, the frequency of MMc in non-Caucasian T1D patients remains to be examined.Methods</stro...