hrp0082fc12.6 | Obesity | ESPE2014

Resveratrol Inhibits Inflammation-Induced Production of Cytokines in Human Adipocytes

Zagotta Ivana , Killian Alexandra , Haas Jennifer , Kietzmann Thomas , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Upon excessive expansion, adipose tissue is infiltrated by macrophages and shows increased production of inflammatory cytokines. This chronic low grade inflammation of adipose tissue is involved in the pathogenesis of insulin resistance. A supplementation with resveratrol can reverse the metabolic disturbances of human obesity, in part by mimicking the effects of caloric restriction.Objective and Hypotheses: We hypothesized that the beneficia...