ESPE Abstracts

Introduction: The increasing prevalence of obesity in children and adolescents is contributing to the increasing diagnosis of insulin resistance (IR) in these individuals. However, it remains a worldwide problem to establish diagnostic criteria of IR in the developmental-age population. IRIHOMA and the IRIBelfiore are the well-known indices used in clinical practice. The aim of the study was to compare the usefulness of IRIBelfiore and IRIHOMA in the early dia...

Introduction: A condition that causes strong inhibition of growth hormone (GH) secretion is, among others, hyperglycemia; this phenomenon is used in the diagnosis of suspected GH excess by performing a GH inhibition test after oral administration of glucose (OGTT). In a healthy adult, it has been established that the nadir of GH concentration should not exceed 1 ng/ml (0.4 ng/ml in the case of sensitive tests). It is unclear whether the same standards should a...

Background: Growth hormone (GH) is a well-known factor affecting bone mineral density (BMD). Adults with GH-deficiency exhibit lower BMD, which improves with treatment. However, to date, little is known about the effects of GHD (growth hormone deficiency) on BMD as well as about BMD in idiopathic short stature (ISS) prepubertal children - who remain short, despite normal GH concentrations in stimulation testing.Aim: The ...