hrp0084fc12.1 | Obesity - Clinical | ESPE2015

Evaluation of Cardiovascular Risk in Childhood: Data from a Survey of Dyslipidaemic Children

Bruzzi Patrizia , Colombini Giulia , Lucaccioni Laura , Predieri Barbara , Iughetti Lorenzo

Background: Dyslipidaemia is a well-known risk factor in developing cardiovascular disease (CVD) already in childhood.Objective and hypotheses: To investigate the clustering of cardiovascular risk-factors (anthropometric parameters, blood pressure and metabolic abnormalities) in different type of dyslipidaemia in children and adolescents.Method: All the subjects aging 2–18 years referred for dyslipidaemia to our endocrine outp...

hrp0092p1-68 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Growth and Cognition at Peri-Pubertal Age in Preterm Infants Very Low Birth Weight: The Role of Extrauterine Growth Restriction (EUGR)

Lucaccioni Laura , Malmusi Giovanni , Talucci Giovanna , Pugliese Marisa , Arrigoni Marta , Spada Caterina , Ferrari Fabrizio , Iughetti Lorenzo

Background: Preterm infants born VLBW can display auxological impairment and long term cognitive disabilities. These outcomes are influenced by the condition of being small for gestational age (SGA), but also by the extra-uterine growth restriction (EUGR). Aim of the study was to detect the influence of gestational age(GA), perinatal growth trend and enteral nutrition during the hospitalization on cognitive and auxological outcomes at peri-pubertal age (PPA).<...

hrp0092p1-417 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (2) | ESPE2019

Hypospadias: Clinical Approach, Surgical Technique and Outcome. Twenty Years' Experience of a Single Centre.

Lucaccioni Laura , Poluzzi Francesca , Durante Viviana , Predieri Barbara , Iughetti Lorenzo , Luca Ceccarelli Pier

Background: Hypospadias is one of the most common congenital abnormalities in male. Nowadays, hypospadias surgical repair has become highly demanding and deeply investigated with more than 300 corrective procedures. Its success is assessed by the "reoperation rate" that occurs short after the surgery within a brief follow-up (6-12 months). However, short-term outcomes may not reflect the long-term ones, as hypospadias repair may influence adolescence a...

hrp0089p2-p032 | Adrenals and HPA Axis P2 | ESPE2018

Adrenal Hypoplasia Seemingly First as a Primary Hypoaldosteronism

Iughetti Lorenzo , Lucaccioni Laura , Bruzzi Patrizia , Ciancia Silvia , Predieri Barbara , Roucher-Boulez Florence

Background: X-linked Congenital Adrenal Hypoplasia (AHC) is a rare cause of primary adrenal insufficiency due to mutations in NR0B1 gene, causing a loss of function of the nuclear receptor protein DAX-1. Adrenal insufficiency usually presents in the first two months of life, but sometimes can appear later in childhood. Hypogonadotropic Hypogonadism is often associated later in life and all patients develop azoospermia. We describe an unusual onset of AHC started with ...

hrp0089p2-p205 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Auxological Catch Up Growth and Evaluation of Spontaneous Motility in the Term Newborn Small for Gestational Age Employing the Prechtl Assessment of General Movements

Lucaccioni Laura , Talucci Giovanna , Leo Francesco , Ciancia Silvia , Russo Giovanna , Ferrari Fabrizio , Iughetti Lorenzo

Introduction: Term newborns Small for Gestational Age (SGA) have an increased risk for minor neurological impairment at pre- and school age. The general movements (GMs) assessment, in particular at Fidgety (F+) age, has been increasingly used to predict neurological dysfunctions. Aim of our study was to evaluate, in a population of term newborn SGA (gestational age >37 weeks) the growth recovery, the presence of F+ at 3 months of age, and the neurological outcome at 2 year...

hrp0086p1-p754 | Pituitary and Neuroendocrinology P1 | ESPE2016

The Metabolic Negative Effect of Gonadotropin-Releasing Hormone Agonist Therapy in Childhood: Is it Short-Term and Reversible?

Iughetti Lorenzo , Bruzzi Patrizia , Bigi Elena , Valeri Lara , Manzotti Elena , Lucaccioni Laura , Predieri Barbara

Background: Data on metabolic effects of gonadotropin-releasing hormone agonist (GnRHa) therapy are still controversial.Objective and hypotheses: To longitudinally evaluate the effect of GnRHa therapy on BMI, glycaemic metabolism and lipid profile in children affected by idiopathic central precocious puberty (CPP).Method: This longitudinal retrospective study included data from 42 children (7.70±0.80 years, 2 males) affected b...

hrp0086p2-p836 | Syndromes: Mechanisms and Management P2 | ESPE2016

Renal Anomalies in Children with Turner Syndrome: Experience from a Single-Centre

Lucaccioni Laura , Wong Sze Choong , Strano Rosario , Donaldson Malcolm , Cascio Salvatore , Mason Avril

Background: Renal abnormalities are estimated to be present in 30–40% of Turner Syndrome (TS). Monosomic patients have a reported greater risk for renal anomalies.Objective: To assess the frequency of renal malformations in TS according to karyotype; and report related complications at most recent follow up.Methods: The medical records of 182 patients with TS born between 1970 and 2013 were retrospectively reviewed.<p clas...

hrp0082p1-d3-169 | Growth (2) | ESPE2014

Recombinant Human GH Therapy Allows to Reach a Normal Final Adult Height in Coeliac Children with GH Deficiency due to Hypophysistis

Iughetti Lorenzo , Lucaccioni Laura , Bruzzi Patrizia , Di Biase Anna Rita , De Bellis Anna Maira , Predieri Barbara

Background: Coeliac disease (CD) can be associated with impaired growth in children after a prolonged period of Gluten-free diet (GFD). A small percentage of CD patients does not show catch-up growth during GFD because of GH secretion deficiency (GHD) that could be associated with antipituitary autoantibodies (APA).Objective and hypotheses: This study aims to evaluate the efficacy of recombinant human GH (rhGH) therapy on final adult height in children w...

hrp0082p2-d2-434 | Growth Hormone (1) | ESPE2014

Metabolic Assessment in Children with GH Deficiency Before, During, and After Human GH Replacement Therapy

Predieri Barbara , Mazzoni Silvia , Paraluppi Valentina , Patianna Viviana , Lucaccioni Laura , Madeo Simona , Bruzzi Patrizia , Iughetti Lorenzo

Background: GH has several effects on lipid and glucose homeostasis. In adults GH deficiency (GHD) has been associated to increased mortality for cardiovascular disease (CVD). In childhood few studies have investigated the effect of GHD and recombinant human GH (rhGH) therapy on metabolic parameters that may increase the risk of CVD.Objective and hypotheses: To assess changes of lipid profile, insulin-resistance indexes, and CVD risk in children and adol...

hrp0082p2-d1-514 | Pituitary | ESPE2014

Urinary Gonadotrophins for Assessment and Management of Pubertal Disorders

Lucaccioni Laura , McNeilly Jane , Mason Avril , Giacomozzi Claudio , Shaikh M Guftar , Iughetti Lorenzo , Ahmed S Faisal

Background: With improvements in assays and an increasing need for non-invasive out-patient based investigations, there is a renewed interest in the use of urinary gonadotrophins (uGn) for assessing pubertal progress.Objective and hypotheses: This study aims to establish the correlation between serum and urinary LH and FSH in patients with pubertal concerns.Method: 36 boys and girls aged 14.9 years (range 7.8–17.3) and 9.5 yea...