hrp0086p1-p923 | Thyroid P1 | ESPE2016

Small Thyroid Volume on Ultrasound in Infants with Transient TSH Elevation Following Referral by Newborn Screening

Mansour Chourouk , Jones Jeremy , Green Morag , Stenhouse Emily , Irwin Greg , Donaldson Malcolm

Background: Infants referred with elevation of capillary TSH on newborn screening are classified as having transient TSH elevation when subsequently found to have normal venous thyroid function tests off treatment with thyroxine. Causes of transient TSH elevation include neonatal sickness, prematurity and maternal thyroid antibodies. There is little information on thyroid size in such infants.Objective: To determine thyroid volume by ultrasound in infant...

hrp0082fc13.4 | Thyroid | ESPE2014

The Prevalence of Congenital Malformations in Infants with TSH Elevation on Newborn Screening: the Importance of Distinguishing Between True and Transient Congenital Hypothyroidism

Ouarezki Yasmine , Mansour Chourouk , Jones Jeremy , alghanay Abubaker , Smith Sarah , Stone David , Donaldson Malcolm

Backgrounds: The prevalence of congenital malformations (CM) is higher in infants referred with capillary (c) TSH elevation on newborn screening. However, establishing the prevalence of CM ± dysmorphic syndromes in true congenital hypothyroidism (CH) requires careful distinction between true and transient CH.Objective: To determine the prevalence of CM ± dysmorphic syndromes in all infants referred with TSH elevation on newborn screening in Sco...

hrp0082p2-d1-591 | Thyroid | ESPE2014

Trends in Median Age at Guthrie Sampling, Laboratory Receipt, Notification, and Start of Treatment for Infants with TSH Elevation on Newborn Screening

Mansour Chourouk , Ouarezki Yasmine , Jones Jeremy , Smith Sarah , Donaldson Malcolm , Mason Avril

Background: Screening for congenital hypothyroidism (CH) has virtually eradicated the severe mental handicap associated with late or absent treatment. We have previously reported two audits of newborn screening for CH between 1979 and 2003 showing significant improvement from the first to more recent period.Objective and hypotheses: We aimed to audit the period 2004–2013 and report trends in timing of sampling, laboratory processing, delay between f...

hrp0084p2-548 | Puberty | ESPE2015

Sensitivity of Measured Parental Height and Target Range in the Diagnosis of Turner Syndrome

Ouarezki Yasmine , Cizmecioglu Filiz , Mansour Chourouk , Jones Jeremy , Gault Emma Jane , Mason Avril , Donaldson Malcolm

Background: Girls with Turner syndrome (TS) are inappropriately short for their parentsÂ’ heights; measured parental height is therefore useful in diagnosis.Objective and hypotheses: To examine the sensitivity of measured parental height in the diagnosis of TS; and to audit the frequency of parental height measurement in our clinic.Method: Case note review of all girls with TS attending our dedicated Turner clinic between 1989&...

hrp0084p2-558 | Thyroid | ESPE2015

Objective vs Subjective Measurement of Thyroid Volume by Ultrasound in Infants Referred with TSH Elevation on Newborn Screening

Mansour Chourouk , Ouarezki Yasmine , Jones Jeremy , Attaie Morag , Stenhouse Emily , Pohlenz Joachim , Donaldson Malcolm

Background: Establishing thyroid size as large, normal or small in newborn infants with TSH elevation and in situ thyroid is important for diagnosis and informing molecular genetic studies.Objective and hypotheses: To compare intra-observer variation in the objective (Ox) measurement of thyroid volume (vol) by ultrasound (US); and the correlation between subjective (Sx) and Ox assessment.Method: Joint blinded retrospective...