hrp0086fc7.2 | Gonads & DSD | ESPE2016

Serum Irisin Concentrations in Lean Adolescents with Polycystic Ovary Syndrome

Bacopoulou Flora , Athanasopoulos Nikos , Mantzou Aimilia , Efthymiou Vassiliki , Lambrou George

Background: The myokine irisin, is associated with the metabolic and hormonal dysregulation of polycystic ovary syndrome (PCOS) in adult women. Recent studies have shown that circulating irisin levels increase in adult women with PCOS.Objective and hypotheses: The purpose of this study was to determine serum concentrations of irisin in lean adolescents with PCOS and healthy controls and to evaluate correlations with clinical, sonographic and hormonal par...

hrp0092p3-275 | Late Breaking Abstracts | ESPE2019

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Normal-Weight, Overweight and Obese Adolescent Females

Bacopoulou Flora , Apostolaki Despoina , Mantzou Aimilia , Doulgeraki Artemis , Pałasz Artur , Koniari Eleni , Efthymiou Vasiliki

Background: The Spexin gene is considered the most dysregulated in obese human fat with an almost complete absence of expression in obese human fat in comparison with non-obese fat tissues. Limited data from human and animal studies suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity.Objective: The aim of this study was to compare serum spexin concentrations betw...

hrp0089p2-p024 | Adrenals and HPA Axis P2 | ESPE2018

The Effectiveness of a Stress-Management Intervention Program in Behavioral Parameters and Hair Cortisol Concentrations in Children with Attention Deficit Hyperactivity Disorder

Kapogiannis August , Makris Gerasimos , Mantzou Aimilia , Bachourou Theodora , Darviri Christina , Chrousos George , Pervanidou Panagiota

Background: Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental condition in school-aged children, with a prevalence of 5┬ľ8%. In individuals with ADHD, there is an attenuated biologic stress response to challenging situations.Objective: This study aimed at evaluating the effectiveness of an 8-week stress management program, comprising self-applied cognitive exercises, on stress perception and anxiety symptoms, sleep...

hrp0089p1-p095 | Fat, Metabolism and Obesity P1 | ESPE2018

Variation of Circulating Brain-Derived Neurotrophic Factor According to Gender, Body Mass Index and Metabolic Syndrome Parameters in Adolescents

Bacopoulou Flora , Tsitsimpikou Christina , Mantzou Aimilia , Apostolaki Despoina , Darviri Christina , Efthymiou Vasiliki

Background: Brain-derived neurotrophic factor (BDNF) plays a role in the central regulation of energy balance and has been associated with body mass index (BMI).Objective: The aim of this study was to investigate potential differences in serum BDNF concentrations in adolescents by gender and BMI, as well as possible correlations of circulating BDNF with the adolescents┬ĺ characteristics of metabolic syndrome.Methods: Study part...

hrp0089p2-p134 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum Spexin Concentrations in Adolescent Females with Metabolic Syndrome, Polycystic Ovary Syndrome and Anorexia Nervosa

Bacopoulou Flora , Efthymiou Vasiliki , Apostolaki Despoina , Tsitsimpikou Christina , Tsarouhas Konstantinos , Darviri Christina , Mantzou Aimilia

Background: Spexin is a novel hormone that may potentially impact food intake, weight regulation and body adiposity. Circulating spexin has been associated with obesity and insulin resistance indices in women.Objective: The aim of this study was to determine serum spexin concentrations in adolescent females with metabolic syndrome, with polycystic ovary syndrome (PCOS), with anorexia nervosa as well as in healthy controls, and explore possible relationsh...

hrp0089p1-p210 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Hypothalamic-pituitary-testicular Axis Response to Sub-maximal Aerobic Exercise, in Pre- and Early- Pubertal Normal Weight and Obese Boys

Paltoglou George , Avloniti Alexandra , Chatzinikolaou Athanasios , Mantzou Aimilia , Stefanaki Charikleia , Papagianni Maria , Fatouros Ioannis , Mastorakos Ge

Objective: To investigate the association of the gonadal axis with pro- and anti- oxidation, in relation to obesity and pubertal status in boys, before and after a stimulatory exercise bout.Design: Cross-sectional human experimental study.Methods: Ninty-two healthy normal-weight and obese pre- and early- pubertal boys, participated in this study. All subjects underwent a baseline blood sampling followed by an aerobic exercise bout ...

hrp0086p1-p378 | Gonads & DSD P1 | ESPE2016

Randomized Controlled Study Comparing Vitamin D and Omega 3-Fatty Acids Supplementation in Adolescents with Polycystic Ovary Syndrome

Bacopoulou Flora , Kolias Evangelia , Aravantinos Leon , Mantzou Aimilia , Doulgeraki Artemis , Spanoudi Filio , Deligeoroglou Efthimios , Charmandari Evangelia

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine genetic disorder, which is associated with increased metabolic and cardiovascular morbidity. Vitamin D or omega-3 fatty acids supplementation may alleviate the metabolic and reproductive complications of PCOS.Objective and hypotheses: To compare clinical, psychometric, biochemical, endocrine, bone and sonographic markers in vitamin D sufficient adolescents with PCOS, pre- and post- 6 mon...

hrp0089p2-p154 | Fat, Metabolism and Obesity P2 | ESPE2018

Hair Cortisol Concentrations in Overweight and Obese Children and Adolescents

Genitsaridi Sofia , Karampatsou Sofia , Papageorgiou Ifigeneia , Mantzou Aimilia , Paltoglou Georgios , Kourkouti Christie , Papathanasiou Chryssanthi , Kassari Penio , Nicolaides Nicolas C , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem of our century that has reached epidemic proportions globally during the last decades. In obese subjects, a relatively high cortisol output in urine has been observed compared to nonobese individuals. However, cortisol concentrations in blood, saliva, and urine in association with obesity have not been consistent across studies. Hair cortisol concentrations (HCC) determined in scalp hair provide...

hrp0084p2-181 | Adrenals | ESPE2015

Baseline Cortisol Concentrations Predict Positively and Negatively Anti- and Pro- Oxidation, Respectively that are Measured Following an Acute Aerobic Exercise Bout in Pre- and Early Pubertal Normal-Weight and Obese Boys

Paltoglou George , Papagianni Maria , Fatouros Ioannis G. , Mantzou Aimilia , Jamurtas Athanasios , Avloniti Alexandra , Stefanaki Charikleia , Kanaka-Gantenbein Christina , Chrousos George P. , Mastorakos George

Background: Little data exist regarding the hypothalamic-pituitary-adrenal (HPA) axis activation and the interplay between the HPA axis and markers of pro- and anti-oxidation in children, following an acute aerobic exercise bout in children.Objective and hypotheses: To investigate the changes of HPA axis hormones following an acute bout of aerobic exercise and their respective association with markers of pro- and anti- oxidation in normal weight and obes...

hrp0095p1-259 | Diabetes and Insulin | ESPE2022

Tear Proteomics in Children and Adolescents with Type 1 Diabetes Mellitus and Correlation with Cognitive Function Levels

Nicolaides Nicolas , Makridakis Manousos , Kitani Rosa-Anna , Letsou Konstantina , Kressou Evangelia , Angelopoulou Eleni , Vasilakis Ioannis-Anargyros , Kosteria Ioanna , Mantzou Aimilia , Papassotiriou Ioannis , Varvogli Liza , Zoidakis Jerome , Kanaka-Gantenbein Christina

Background: Several studies have shown that type 1 diabetes mellitus (T1DM) may contribute to the early onset or acceleration of cognitive impairment (intelligence, psychomotor efficiency, information management speed, visual attention, visual perception and cognitive flexibility). Tear proteomics seems to provide useful information for understanding the molecular mechanisms of various ocular and systemic diseases.Objective and H...