hrp0095p1-555 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Management Options for Adolescents with Abnormal Uterine Bleeding, according to their Demographic, Clinical and Laboratory Characteristics.

Keidar Noa , Smorgick Noam , Rachmiel Marianna

Background: Abnormal uterine bleeding is a common complaint among adolescents, however, there are no evidence-based guidelines for their treatment, and there is a paucity of outcome data available.Objectives: To describe the characteristics of adolescents with menstrual abnormalities and to describe management protocol outcomes.Methods: This is a retrospective study, based on infor...

hrp0094p2-90 | Bone, growth plate and mineral metabolism | ESPE2021

Changing reality: rebirth of old diseases in new circumstances. Severe vitamin D deficiency presenting as hypocalcemic seizures in a healthy adolescent after prolonged COVID-19 lock-down.

Naugolny Larissa , Rachmiel Marianna , Weintrob Naomi ,

Context: Nutritional vitamin D deficiency is rare in the high income countries; its manifestations are usually associated with the combination of accompanying risk factors, as malnutrition, chronic illness, dark skin or restricted exposure to sunlight due to cultural practices.Objective: The aim of this case report is to increase the awareness to severe vitamin D deficiency as a result of extreme indoor isolation due to ...

hrp0097lb13 | Late Breaking | ESPE2023

Low-Dose Liraglutide-Induced Acute Kidney Injury and Hepatocellular Disorder in an Adolescent Patient

Wittenberg Avigail , Komargodski Rinat , Rachmiel Marianna

Background: Liraglutide (SAXENDA®) is a glucagon-like peptide 1 (GLP-1) receptor agonist approved as an adjunct for chronic weight management in combination with a reduced-calorie diet and increased physical activity. Previous case reports have suggested an association between liraglutide use and acute kidney injury in adults, particularly at maintenance doses of 1.2 mg/day or higher. However, there is less data on the impact of liraglutide in the adolesce...

hrp0089p2-p023 | Adrenals and HPA Axis P2 | ESPE2018

Adrenal Crisis in Children with Adrenal Insufficiency: Prevalence and Risk Factors

Eyal Ori , Levin Yair , Oren Asaf , Zung Amnon , Rachmiel Marianna , Landau Zohar , Weintrob Naomi

Objectives: To assess the prevalence and risk factors of Adrenal crisis (AC) events in children with Adrenal insufficiency (AI) and to evaluate the effectiveness of the treatment for preventing AC.Methods: Children diagnosed with AI between 1990 and 2017 and treated with glucocorticoids at four pediatric endocrinology units in Israel were studied. Data were retrieved retrospectively from the patientsÂ’ files and they included demographic factors (age...

hrp0095p1-252 | Diabetes and Insulin | ESPE2022

Novel insights on the associations between specific brain tract segmental alterations, glucose levels, and cognitive performance among adolescents with type 1 diabetes

Litmanovitch Edna , Geva Ronny , leshem Avital , Lezinger Mirit , Heyman Eli , Gidron Maor , Yarmolovski Jessica , Sasson Efrat , Tal Sigal , Rachmiel Marianna

Objective: The overarching hypothesis explored in this research was discerning the relations between the neuro-cognitive accomplishments of adolescents with T1D patients and healthy siblings of similar age, according to the transient glucose excursions, and the quantitative parameters of white matter in specific pathways according to glycaemic control.Research Design and Methods: A case-control study included 12-18 years...

hrp0095p1-449 | Diabetes and Insulin | ESPE2022

Do-It-Yourself Artificial Pancreas Systems in a PediatricPopulation with Type 1 Diabetes in a Real-life Setting: The AWeSoMe Study Group Experience

Nir Judith , Rachmiel Marianna , Fraser Abigail , Lebenthal Yael , Brener Avivit , Pinhas-Hamiel Orit , Haim Alon , Stern Eve , Levek Noa , Ben-Ari Tal , Landau Zohar

Aims: Do-It-Yourself Artificial Pancreas Systems (DIYAPS) represent a unique patient-initiated treatment in which commercially available and approved medical devices such as continuous glucose monitoring systems (CGMs) and insulin pumps are connected by an off-label algorithm, and are remotely controlled by open-source algorithms to automate insulin delivery. While these systems are co-created by the DIYAPS community, and access is open to everyone, users have...

hrp0097p1-238 | Diabetes and Insulin | ESPE2023

MiniMed 780G Advanced Hybrid Closed Loop System Outcomes According to Pubertal Status - Awesome Study Group Real-Life Experience

Rachmiel Marianna , Lebenthal Yael , Kineret Mazor-Aronovitch Kineret , Brener Avivit , Levek Noah , Polishuk-Yakobi Talia , Tal Ben Tal , Abiri Shirli , Landau Zohar , Pinhas-Hamiel Orit

Background and aims: Achieving good glycemic control is a major challenge for adolescents with type 1 diabetes (TID). The introduction of the MiniMed 780G system, an advanced hybrid closed-loop (AHCL), that enables an automatic correction of insulin, gave hope for improved glycemic outcomes in adolescents. We assessed specific characteristics associated with glycemic measures in youth with T1D switching to Minimed 780G.Methods:</...

hrp0095p1-42 | Diabetes and Insulin | ESPE2022

Symptoms and Glycemic Control in Young People with Type 1 Diabetes following SARS-CoV-2 Infection: an Observational Study

Nimri Revital , Rachmiel Marianna , Yackobovitch-Gavan Michal , Brener Avivit , de Vries Liat , Fisch Shvalb Naama , Lazar Liora , Oren Asaf , Jacobi-Polishook Talia , Shefer Averbuch Noa , Tenenbaum Ariel , Mel Eran , Krepel Volsky Sari , Mouler Marie , Demol Sharon , Shalitin Shlomit , Bello Rachel , Phillip Moshe , Lebenthal Yael

Objective: To describe clinical manifestations of SARS-CoV-2 infection in children, adolescents, and young adults with established type 1 diabetes and explore the effects of COVID-19 on glycemic control and disease course.Methods: Observational study conducted at three pediatric diabetes clinics in Israel between mid-March-2020 and mid-March-2021. Included were young people with established type 1 diabetes, <30years, ...

hrp0089fc10.6 | Late Breaking | ESPE2018

Primary Ovarian Insufficiency Incidence Rate and ETIOLOGY AMONG ISRAELI ADOLESCENTS between the Years 2000–2016 – A Multi-Center Study

Gruber Noah , Kugler Shir , de Vries Liat , Brener Avivit , Zung Amnon , Eyal Ori , Rachmiel Marianna , Koren Ilana , Tenenbaum-Rakover Yardena , Hershkovitz Eli , Landau Zohar , Oren Meirav , Eliakim Alon , Zangen David , German Alina , Majdoub Hussein , Mazor-Aronovitch Kineret , Modan-Moses Dalit , Yeshayahu Yonatan , Naugolni Larisa , Levy-Shraga Yael , Ben-Ami Michal , Brill Gherta , Levy-Khademi Floris , Avnon-Ziv Carmit , Tiosano Dov , Harel Shira , Kedem Einat , Segev-Becker Anat , Shoenfeld Yehuda , Pinhas-Hamiel Orit

Introduction: Primary ovarian Insufficiency (POI) occurring in youth is a devastating condition. POI is characterized by at least 4 months of disordered menses in association with menopausal follicle stimulating hormone (FSH) levels. The most common causes of POI in adolescence are iatrogenic and chromosomal abnormalities. Data are scarce regarding the incidence of POI in adolescents.Objectives: We aimed to estimate the incidence and the distribution of ...