ESPE Abstracts

Background and Purpose: Previous studies have shown that autoimmunity in patients with type 1 diabetes mellitus (T1DM) begins long before the onset of clinical manifestations. Viruses, such as Coxsackie virus, play an important role in the complex and multifactorial etiology of T1DM. Human hair grows by 1 cm per month. A variety of endogenous molecules such as proteins, metabolites and hormones are incorporated during hair growth, so that a hair sample can pro...

Background and Purpose: Previous studies have shown differences in serum, plasma, or saliva proteomics profile in patients with type 1 diabetes mellitus (T1DM), compared with healthy controls. The purpose of this prospective study is to identify the tear proteomics profile in children with T1DM that are followed at the Diabetes Center of the First Department of Pediatrics of the National and Kapodistrian University of Athens, at “Aghia Sophia” Chil...

Background/Aim: Congenital hyperinsulinism (CHI) is a group of genetic disorders characterized by impaired insulin secretion, resulting in recurrent hypoglycaemia. Aim of this study is to investigate the proteomic profile in tear samples in children and adolescents with congenital hyperinsulinism who are treated and followed up at our Division. The tears’ proteomic profile will be correlated with the clinical presentation and laboratory data of the patie...