hrp0082p2-d2-598 | Thyroid (1) | ESPE2014

An Unusual Presentation of Acquired Hypothyroidism: the Van Wyk–Grumbach Syndrome

Isguven Pinar , Uluc Nefise , Kosecik Mustafa , Karacan Mehmet , Ermis Bahri

Background: Van Wyk–Grumbach syndrome (VWGS) is characterized by breast development, uterine bleeding and multi-cystic ovaries in the presence of long-lasting primary hypothyroidism.Objective and hypotheses: The pathophysiology of VWGS involves a complex mechanism, which is at least partly mediated by the direct action of TSH and FSH receptors.Method: We present a girl with Down syndrome having typical feature...