hrp0097fc9.6 | Diabetes and insulin 2 | ESPE2023

Puberty and Gonadal function in Wolfram Syndrome: A retrospective single centre study

Cunningham Olivia , Newell Laura , McCarthy Liam , Williams Denise , Barrett Timothy , Dias Renuka

Background: Wolfram Syndrome (WS) is a rare progressive neurodegenerative disorder characterised by early-onset diabetes and optic atrophy as well as a variable spectrum of other clinical features. It is caused by mutations in the WFS1 gene. There is currently limited published literature on pubertal progression and gonadal function in WS.Aims: To review the gonadal function and pubertal progression of a cohort of adoles...